2020
DOI: 10.1111/nph.17031
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Abstract: Phytochemicals are used often in vitro and in vivo in cancer research. The plant hormones jasmonates (JAs) control the synthesis of specialized metabolites through complex regulatory networks. JAs possess selective cytotoxicity in mixed populations of cancer and normal cells. Here, direct incubation of leaf explants from the non-medicinal plant Arabidopsis thaliana with human breast cancer cells, selectively suppresses cancer cell growth. High-throughput LC-MS identified Arabidopsis metabolites. Protein and tr… Show more

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Cited by 15 publications
(7 citation statements)
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“…Mitochondria are pivotal in the detection of and adaptation to stress, sending out redox signals in response to stress, which may be an important mechanism explaining how plant secondary metabolites work as medicines via a process called mitohormesis ( Tapia, 2006 ). Critically, evidence is accumulating that major plant stress signaling compounds, such as jasmonates, can modulate mitochondria in both plant and animal cells ( Bömer et al, 2020 ). Moreover, plant compounds are known to interfere with glycolytic pathways and major controllers of metabolism, such as VDAC.…”
Section: Discussionmentioning
confidence: 99%
“…Mitochondria are pivotal in the detection of and adaptation to stress, sending out redox signals in response to stress, which may be an important mechanism explaining how plant secondary metabolites work as medicines via a process called mitohormesis ( Tapia, 2006 ). Critically, evidence is accumulating that major plant stress signaling compounds, such as jasmonates, can modulate mitochondria in both plant and animal cells ( Bömer et al, 2020 ). Moreover, plant compounds are known to interfere with glycolytic pathways and major controllers of metabolism, such as VDAC.…”
Section: Discussionmentioning
confidence: 99%
“…The antitumor activity of methyl jasmonate (MJ) was found to be higher than other jasmonates; therefore, MJ and its synthetic derivatives have recently been studied more intensively as promising compounds for the treatment of cancer [ 25 ]. MJ has been shown to prolong the survival of mice with EL-4 lymphoma and mice vaccinated with multiple myeloma cells (MM.1S) [ 21 , 26 ].…”
Section: Pharmacological Activity Of Jasmonatesmentioning
confidence: 99%
“…At the highest concentration tested, MJ caused more than a 90% reduction in the viability of all MM cell lines [ 26 ]. The cytotoxic effect of MJ (0.2–2000 µM) was also selective for MDA-MB-361 and T-47D human breast cancer cells [ 25 ]. The highest inhibition of the growth of T-47D and MDA-MB-361 cells was observed at 2 mM MJ (cell survival was 47% and 78%, respectively).…”
Section: Pharmacological Activity Of Jasmonatesmentioning
confidence: 99%
“…These metabolites are very promising anticancer drugs in humans ( Miller, Neilan & Sze, 2008 ; Sriram et al, 2005 ). Although credible evidence on a mechanism of action was missing until recently ( Bömer et al, 2020 ). Studies have been conducted to optimize the production of these substances; focusing on their metabolic pathways, selecting more productive cell lines, optimizing cell culture processes, product purification, and up scaling of the whole process ( Bai et al, 2004 ; Miller, Neilan & Sze, 2008 ; Onrubia et al, 2013 ; Syklowska-Baranek et al, 2009 ; Tabata, 2006 ; Wilson & Roberts, 2012 ).…”
Section: Introductionmentioning
confidence: 99%