January 2018 at a glance: biomarkers, co‐morbidities and mechanical circulatory support

Seipin Knockout Mice Develop Heart Failure With Preserved Ejection Fraction

“…Meanwhile, the diastolic stiffness coefficient β derived from EDPVR was steadily higher in SKO mice (Figure 3C). Similar to Asian HFpEF patients that exhibited reduced exercise tolerance (6), when compared with the Ctrl group, SKO mice displayed exercise intolerance (reduced running distance and running time) beginning in young adulthood (∼15 weeks old)(Figure 3D). Consistent with compromised diastolic function, the LA size and weight of SKO mice (∼36 weeks old) were significantly increased (Figure 3E).…”

“…HFpEF represents a broad cohort of patients with a range of comorbidities, such as hypertension, obesity, and diabetes, that requires individualized management based on biological phenotypes (4,5). However, recent epidemiologic data from Asia suggest a unique lean diabetic phenotype of HFpEF, compared with other HF phenotypes, has the worst quality of life, more severe signs and symptoms of HF, and the highest rate of adverse clinical outcomes (6, 7, 8).…”