Jade family PHD finger 3 (JADE3) increases cancer stem cell-like properties and tumorigenicity in colon cancer

Jian, Yunting; Wang, Meng; Zhang, Yan; Ou, Ruizhang; Zhu, Ziyuan; Ou, Yangying; Chen, Xiangfu; Liang, Xin; Ding, Yan‐Qing; Song, Libing; Xu, Xuehu; Liao, Wenting

doi:10.1016/j.canlet.2018.04.012

Cited by 13 publications

(10 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…JADE3 must be expressed, so that the tumorigenic characteristics of cancer cells in the body can reduce the damage to the human body. The promoters of the JADE3 interaction (colon cancer stem cell markers) and LGR5 promoted acetyltransferase and histone acetylation of p300 in terms of activated transcription, so signi cantly induced Wnt/jp-catenin signaling to some extent (17). For another example, NORAD (Non-Coding RNA Activated By DNA Damage) is an RNA Gene, and is a liated with the lncRNA class.…”

Section: Discussionmentioning

confidence: 99%

SNP Mutation‐related Genes in Colon Cancer for Monitoring and Prognosis of Patients: A Study Based on the TCGA Database

Liao

Chen

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Cancer is still the leading cause of death in humans, and the fourth leading cause of death is colorectal cancer. Tumor bioinformatics has been developing in recent years, the prognosis and quality of life of patients can be improved by using relevant tools to understand the molecular pathogenesis of colorectal cancer and related prognostic markers. Methods: In this study, Bioinformatics analysis of the snp-related data of colon cancer patients from the TCGA database, it was found that the expression levels of 4 mutated genes (CTTNBP2,DAPK1, DMXL1,SPTBN2) were significantly different from those of wild type and their prognosis. In order to explore how the core genes affect the prognosis of patients, the gene expression of these core genes was analyzed. Results: It was found that the core genes are related to a variety of cancer-related pathway genes, including pi3k-akt pathway and TSC/mTOR pathway. Drug sensitivity analysis showed that SPTBN2 could be inhibited by a variety of drugs, including austocystin D, afatinib, and belinostat. Tumor immunity is closely related to tumor therapy. Through the analysis of immune infiltration of core genes, it was found that DAPK1 and DMXL2 were associated with a variety of immune cell infiltration. Conclusion: Therefore, the detection of genetic mutations and related expressions may be significant in predicting the prognosis of patients with colon cancer. Through the study of high-throughput information excavating, it was discovered that the molecular pathogenesis and prognosis of patients with colon cancer were helpful to the bioinformatics theory.

show abstract

Section: Discussionmentioning

confidence: 99%

SNP Mutation‐related Genes in Colon Cancer for Monitoring and Prognosis of Patients: A Study Based on the TCGA Database

Liao

Chen

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…43 Similarly, TGF-induced Smad7 negatively controls TGF receptor TβRI activity. 44 Interestingly, Phf16 has been recently shown as a Wnt-induced gene, 45 suggesting that it may either directly or indirectly affect Wnt pathways. Therefore, Phf16 induction by antiadipogenic chemicals may negatively act on Wnt or TGF-signaling pathways, which may in turn affect adipocyte differentiation and Pparγ.…”

Section: Discussionmentioning

confidence: 99%

Identification of Phf16 and Pnpla3 as new adipogenic factors regulated by phytochemicals

Chang

Yun

Choi

et al. 2018

J of Cellular Biochemistry

View full text Add to dashboard Cite

Adipocyte differentiation is controlled by multiple signaling pathways. To identify new adipogenic factors, C3H10T1/2 adipocytes were treated with previously known antiadipogenic phytochemicals (resveratrol, butein, sulfuretin, and fisetin) for 24 hours. Commonly regulated genes were then identified by transcriptional profiling analysis. Three genes (chemokine (C-X-C motif) ligand 1 [Cxcl1], heme oxygenase 1 [Hmox1], and PHD (plant homeo domain) finger protein 16 [Phf16]) were upregulated while two genes (G0/G1 switch gene 2 [G0s2] and patatin-like phospholipase domain containing 3 [Pnpla3]) were downregulated by these four antiadipogenic compounds. Tissue expression profiles showed that the G0s2 and Pnpla3 expressions were highly specific to adipose depots while the other three induced genes were ubiquitously expressed with significantly higher expression in adipose tissues. While Cxcl1 expression was decreased, expressions of the other four genes were significantly increased during adipogenic differentiation of C3H10T1/2 cells. Small interfering RNA–mediated knockdown including Phf16 and Pnpla3 indicated that these genes might play regulatory roles in lipid accumulation and adipocyte differentiation. Specifically, the silencing of two newly identified adipogenic genes, Phf16 or Pnpla3, suppressed lipid accumulation and expression of adipocyte markers in both 3T3-L1 and C3H10T1/2 cells. Taken together, these data showed previously uncovered roles of Phf16 and Pnpla3 in adipogenesis, highlighting the potential of using phytochemicals for further investigation of adipocyte biology.

show abstract

“…CSCs are a type of tumor cells that can self-renew and maintain the ability to proliferate and differentiate for a long time. It plays an important role in the proliferation, metastasis, recurrence and tumor resistance of many malignancies, such as non-small cell lung cancer [4] , ovarian cancer [5] , breast cancer [6] , gastric cancer [7] and colorectal cancer [8][9][10] .…”

Section: Introductionmentioning

confidence: 99%

Identification of tumor stem cell regulatory genes related to prognosis of colon cancer by co expression analysis

Zeng,

Wang,

et al. 2024

Preprint

View full text Add to dashboard Cite

Background: Cancer stem cells play a key role in the progression and therapy resistance of colon adenocarcinoma (COAD). In this study, we investigated and identified stem cell-regulated genes associated with COAD prognosis by co-expression network analysis. Methods: R software was used to analyze the mRNA expression stemness index (mRNAsi) of COAD, and the differentially expressed genes were screened out to conduct weighted gene co-expression network analysis (WGCNA). Functional analysis and prognostic analysis were performed on the key modules and genes obtained from WGCNA. Multivariate Cox regression analysis was used to construct the prognosis prediction model of COAD. Result: The mRNAsi in tumor tissue was significantly higher than that in normal tissue. The prognosis of patients in the high mRNAsi group was significantly better than that in the low mRNAsi group. Co-expression network analysis showed that the yellow module was significantly positively correlated with mRNAsi, while the brown and green modules were significantly negatively correlated with mRNAsi. We selected highly correlated genes from the three modules for survival analysis, and found that 20 genes were significantly correlated with patient prognosis. The above genes were included in a multivariate Cox regression analysis, and a risk prediction model consisting of eight genes was finally constructed. The receiver operating characteristic (ROC) curve showed that the accuracy and specificity of the prognosis prediction model were high (AUC=0.738). Conclusion: The 8 prognostic tumor stem cell regulation-related genes identified in this study can be used as sensitive indicators to predict the prognosis of COAD.

show abstract

Jade family PHD finger 3 (JADE3) increases cancer stem cell-like properties and tumorigenicity in colon cancer

Cited by 13 publications

References 46 publications

SNP Mutation‐related Genes in Colon Cancer for Monitoring and Prognosis of Patients: A Study Based on the TCGA Database

SNP Mutation‐related Genes in Colon Cancer for Monitoring and Prognosis of Patients: A Study Based on the TCGA Database

Identification of Phf16 and Pnpla3 as new adipogenic factors regulated by phytochemicals

Identification of tumor stem cell regulatory genes related to prognosis of colon cancer by co expression analysis

Contact Info

Product

Resources

About