Jacaric Acid, a Linolenic Acid Isomer with a Conjugated Triene System, Reduces Stearoyl-CoA Desaturase Expression in Liver of Mice

Shinohara, Nahoko; Ito, Junya; Tsuduki, Tsuyoshi; Honma, Tetsuo; Kijima, Ryo; Sugawara, Soko; Arai, Tatsuya; Yamasaki, Masao; Ikezaki, Aya; Yokoyama, M. T.; Nishiyama, Kazuo; Nakagawa, Kiyotaka; Miyazawa, Teruo; Ikeda, Ikuo

doi:10.5650/jos.61.433

Cited by 31 publications

(29 citation statements)

References 28 publications

(22 reference statements)

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“…Previous studies showed that exogenous oleic acid or palmitoleic acid completely abrogated the action of t10, c12-CLA 11,18 . Interestingly, dietary jacaranda seed oil decreased the delta-9 desaturation index in the liver and adipose tissue and showed inhibitory effects on SCD-1 mRNA expression in the liver of ICR mice 19 . As already described, JFA contains 11.1 oleic acid; however, the cytotoxic effect of JFA was not inferior than that of pure JA.…”

Section: Figmentioning

confidence: 99%

Induction of Apoptotic Cell Death in HL-60 Cells by Jacaranda Seed Oil Derived Fatty Acids

et al. 2013

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Section: Figmentioning

confidence: 99%

Induction of Apoptotic Cell Death in HL-60 Cells by Jacaranda Seed Oil Derived Fatty Acids

et al. 2013

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“…This has been observed with jacaric acid, which downregulated the expression of stearoyl-CoA desaturase, a key enzyme in fatty acid metabolism, in the liver of mice [22]. When administered alone, ursolic acid increased the activity of the lipolytic enzymes in primary cultures of adipocytes [23], inhibited the predifferentiation of the preadipocytes, stimulated lipolysis in the 3T3-L1 cells [24], and, in this study, reduced the total body mass and WAT in vivo .…”

Section: Discussionmentioning

confidence: 88%

Antiobesity Effects of Hydroethanolic Extract of Jacaranda decurrens Leaves

Antunes

Baldivia

Rocha

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Obesity is a worldwide epidemic that reduces life expectancy; therefore, the search for new alternative and effective treatments is ongoing. The aim of the present investigation was to identify the chemical compounds in the hydroethanolic extract of leaves of Jacaranda decurrens subsp. symmetrifoliolata and to evaluate their toxicity and antiobesity effects. High-performance liquid chromatography was used to identify the chemical constituents, and acute toxicity was evaluated in rats treated with doses of 2 and 5 g·kg−1 body mass. The antiobesity effect was determined in rats with hypercaloric diet-induced obesity. Our results revealed the presence of compounds, such as jacaric, ursolic, and oleic acids, as well as luteolin, quercetin, and kaempferol, in the extract. The acute toxicity tests revealed that rats treated with elevated doses of the extract showed no signs of toxicity. The extract induced reduction in total body mass and the white adipose tissue depots. The obese rats treated with the extract showed an increased fluid intake and feces excretion while their serum total cholesterol and triglyceride levels decreased compared to those in the controls, without any hematological changes. Taken together, the results showed that the constituents of J. decurrens extracts included phenolic compounds and exhibited antiobesity effects with no toxicity.

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“…Dietary treatments (LnA, CLnA and CLA) of both experiments, caused decreased the amount of MUFA, whereas the PUFA level was increased in adipose tissue, the SFA level was unchanged. Shinohara et al analyzed fatty acid profile of different tissues of ICR mice fed jacardic acid. Authors reported that levels of MUFA in liver and white adipose tissue were also decreased.…”

Section: Discussionmentioning

confidence: 99%

Margarine supplemented with conjugated linolenic acid (CLnA) has no effect on atherosclerosis but alleviates the liver steatosis and affects the expression of lipid metabolism genes in apoE/LDLR^‐/‐ mice

Franczyk-Żarów¹,

Czyzyńska²,

Drahun³

et al. 2014

Euro J Lipid Sci & Tech

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Margarine supplemented with conjugated linolenic acid (CLnA) has no effect on atherosclerosis but alleviates the liver steatosis and affects the expression of lipid metabolism genes in apoE/LDLR -/-mice The objective of this study was to evaluate the effect of margarine supplemented with punicic acid (cis-9, trans-11,cis-13 C18:3) (CLnA) compared to CLA and linolenic acid (LnA) in apoE/LDLR -/-mice in two independent experiments: LONG (18 weeks) and SHORT (10 weeks). Liver weight was increased in CLA group in both studies. Hepatic steatosis was found in animals fed CLA and margarine diets but less signs of the steatosis were observed in mice fed LnA and CLnA diets. In LONG, TC was significantly increased in animals fed LnA, whereas LDL þ VLDL, HDL and TAG levels were unchanged. In mice fed CLnA the upregulated expression of PPARa and ACO was reported, however, SREBP-1 was 7-fold increased. Punicic acid and CLA isomers were determined both in adipose tissue and liver in CLnA fed mice. No effects of treatments on the area of atherosclerotic plaque were recognized. In conclusion margarine supplemented with CLA significantly increased liver weight and induced steatosis in mice in both studies. Our results did not support the notion that CLnA supplementation to the margarine possesses anti-atheroclerotic effect but it alleviated the liver steatosis and affected the expression of lipid metabolism genes.Practical applications: It has been reported that conjugated linolenic acid isomers (CLnA) have several health-related effects. Margarine with omega-3 fatty acids is commonly used as a functional food product. Therefore, the effect of margarine supplemented with CLnA compared to CLA and linolenic acid (LnA) in apoE/LDLR -/-mice was evaluated. CLA supplementation increased liver weight and lead to steatosis, but CLnA alleviated the liver steatosis in mice. No effects of treatments on the area of atherosclerotic plaque were recognized. The up-regulated expression of PPARa and SREBP-1 and their target genes ACO and FAS was reported for studied fatty acids. More research is warranted to assess the potential health-related properties of conjugated linolenic acids as bioactive compounds in the context of production of functional foods.

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Jacaric Acid, a Linolenic Acid Isomer with a Conjugated Triene System, Reduces Stearoyl-CoA Desaturase Expression in Liver of Mice

Cited by 31 publications

References 28 publications

Induction of Apoptotic Cell Death in HL-60 Cells by Jacaranda Seed Oil Derived Fatty Acids

Induction of Apoptotic Cell Death in HL-60 Cells by Jacaranda Seed Oil Derived Fatty Acids

Antiobesity Effects of Hydroethanolic Extract of Jacaranda decurrens Leaves

Margarine supplemented with conjugated linolenic acid (CLnA) has no effect on atherosclerosis but alleviates the liver steatosis and affects the expression of lipid metabolism genes in apoE/LDLR^‐/‐ mice

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Jacaric Acid, a Linolenic Acid Isomer with a Conjugated Triene System, Reduces Stearoyl-CoA Desaturase Expression in Liver of Mice

Cited by 31 publications

References 28 publications

Induction of Apoptotic Cell Death in HL-60 Cells by Jacaranda Seed Oil Derived Fatty Acids

Induction of Apoptotic Cell Death in HL-60 Cells by Jacaranda Seed Oil Derived Fatty Acids

Antiobesity Effects of Hydroethanolic Extract of Jacaranda decurrens Leaves

Margarine supplemented with conjugated linolenic acid (CLnA) has no effect on atherosclerosis but alleviates the liver steatosis and affects the expression of lipid metabolism genes in apoE/LDLR‐/‐ mice

Contact Info

Product

Resources

About

Margarine supplemented with conjugated linolenic acid (CLnA) has no effect on atherosclerosis but alleviates the liver steatosis and affects the expression of lipid metabolism genes in apoE/LDLR^‐/‐ mice