Ivy/neurogliaform interneurons coordinate activity in the neurogenic niche

Markwardt, Sean J.; Dieni, Cristina V.; Wadiche, Jacques I.; Overstreet-Wadiche, Linda

doi:10.1038/nn.2935

Cited by 79 publications

(73 citation statements)

References 15 publications

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“…Ivy cells are the quantitatively most abundant type of GABAergic interneuron in the CA1 area 25 . They provide widespread synaptic and extrasynaptic slow GABAergic input, as well as NPY and nitric oxide to pyramidal cell dendrites and Schaffer collateral/commissural terminals via their exceptionally dense axonal arborizations 25,26 and may mediate the activity-dependent regulation of neurogenesis 43 . The firing patterns identified here, are well suited to control homeostasis in the network.…”

Section: Discussionmentioning

confidence: 99%

Behavior-dependent specialization of identified hippocampal interneurons

et al. 2012

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A large variety of GABAergic interneurons control information processing in hippocampal circuits governing the formation of neuronal representations. Whether distinct hippocampal interneuron types contribute differentially to information-processing during behavior is not known. We employed a novel technique for recording and labeling interneurons and pyramidal cells in drug-free, freely-moving rats. Recorded parvalbumin-expressing basket interneurons innervate somata and proximal pyramidal cell dendrites, whereas nitric-oxide-synthase-and neuropeptide-Y-expressing ivy cells provide synaptic and extrasynaptic dendritic modulation. Basket and ivy cells showed distinct spike timing dynamics, firing at different rates and times during theta and ripple oscillations. Basket but not ivy cells changed their firing rates during movement, sleep and quiet wakefulness, suggesting that basket cells coordinate cell assemblies in a behavioral state-contingent manner, whereas persistently-firing ivy cells might control network excitability and homeostasis. Different interneuron types provide GABA to specific subcellular domains at defined times and rates, thus differentially controlling network activity during behavior.GABAergic interneurons control information processing in cortical circuits as percussionists set the rhythm for a melody, or traffic lights regulate the movement of cars through a city. Interneurons generate oscillatory activity 1, 2 , synchronize the activity of pyramidal cells 3 and set time windows for synaptic integration 4 . A large diversity of interneuronal types is a hallmark of cortical circuits. Different domains of pyramidal cells, such as the soma, axoninitial-segment, proximal or distal dendrites 5 are innervated by distinct types of GABAergic interneuron. They also have distinct inputs and membrane properties 6-10 and show different firing patterns during network oscillations induced in vitro [11][12][13][14] or recorded in anesthetized animals 15 , indicating distinct roles for specific interneuron types. However, research on interneurons in drug-free animals that can freely change their behavior, has so far been limited to recordings from unidentified interneurons because of technical limitations. In the barrel cortex of head-restrained mice, groups of interneurons with distinct membrane dynamics during different behavioral states have been described 16,17 and in the hippocampus unidentified interneurons or interneurons belonging to heterogeneous groups expressing parvalbumin and/or somatostatin have been reported [18][19][20][21] to fire with different firing patterns during network oscillations. But, how do specific types of identified interneurons control the activity of cortical circuits in freely-moving animals? CouldCorrespondence and requests for materials should be addressed to D.L. (damien.lapray@pharm.ox.ac.uk) Results Identification of neurons recorded in freely-moving ratsWe recorded the activity of parvalbumin (PV)-expressing basket, ivy and pyramidal cells in the dorsal CA...

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Section: Discussionmentioning

confidence: 99%

Behavior-dependent specialization of identified hippocampal interneurons

et al. 2012

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“…The first synaptic inputs onto new granule neurons are GABAergic, and running, which accelerates granule cell maturation, enhances GABA in the dentate gyrus (Markwardt et al, 2011;Snyder et al, 2009b). In fact, the anxiolytic-like effects of running are blocked by GABA receptor antagonists in mice , suggesting that running and anxiolytic drugs may share the same mechanism.…”

Section: Anxietymentioning

confidence: 99%

Adult Neurogenesis and Mental Illness

Schoenfeld

Cameron

2014

Neuropsychopharmacol

162

108

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Several lines of evidence suggest that adult neurogenesis, the production of new neurons in adulthood, may play a role in psychiatric disorders, including depression, anxiety, and schizophrenia. Medications and other treatments for mental disorders often promote the proliferation of new neurons; the time course for maturation and integration of new neurons in circuitry parallels the delayed efficacy of psychiatric therapies; adverse and beneficial experiences similarly affect development of mental illness and neurogenesis; and ablation of new neurons in adulthood alters the behavioral impact of drugs in animal models. At present, the links between adult neurogenesis and depression seem stronger than those suggesting a relationship between new neurons and anxiety or schizophrenia. Yet, even in the case of depression there is currently no direct evidence for a causative role. This article reviews the data relating adult neurogenesis to mental illness and discusses where research needs to head in the future.

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“…The order in which these inputs become functionally connected to abGCs has been the subject of considerable study ( (Markwardt et al 2011). GABA is depolarizing at this time (due to immature, high internal chloride concentration), but when exogenously applied inhibits cell firing via shunting (Overstreet-Wadiche et al 2005).…”

Section: Afferent Synaptic Connectivitymentioning

confidence: 99%

Adult neurogenesis in the mammalian hippocampus: Why the dentate gyrus?

2013

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In the adult mammalian brain, newly generated neurons are continuously incorporated into two networks: interneurons born in the subventricular zone migrate to the olfactory bulb, whereas the dentate gyrus (DG) of the hippocampus integrates locally born principal neurons. That the rest of the mammalian brain loses significant neurogenic capacity after the perinatal period suggests that unique aspects of the structure and function of DG and olfactory bulb circuits allow them to benefit from the adult generation of neurons. In this review, we consider the distinctive features of the DG that may account for it being able to profit from this singular form of neural plasticity. Approaches to the problem of neurogenesis are grouped as “bottom-up,” where the phenotype of adult-born granule cells is contrasted to that of mature developmentally born granule cells, and “top-down,” where the impact of altering the amount of neurogenesis on behavior is examined. We end by considering the primary implications of these two approaches and future directions.

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Ivy/neurogliaform interneurons coordinate activity in the neurogenic niche

Cited by 79 publications

References 15 publications

Behavior-dependent specialization of identified hippocampal interneurons

Behavior-dependent specialization of identified hippocampal interneurons

Adult Neurogenesis and Mental Illness

Adult neurogenesis in the mammalian hippocampus: Why the dentate gyrus?

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