Ivabradine in Postural Orthostatic Tachycardia Syndrome: A Review of the Literature

Tahir, Faryal; Arif, Taha Bin; Majid, Zainab; Ahmed, Jawad; Khalid, Muhammad Rahman

doi:10.7759/cureus.7868

Cited by 19 publications

(18 citation statements)

References 41 publications

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“…The diagnosis of POTS is based on three factors: firstly, clinical syndrome characterised by light-headedness, blurry vision, palpitations, exercise intolerance and fatigue; secondly, an increase of > 30 bpm on standing from recumbent position; and thirdly, the absence of orthostatic hypotension [ 3–5 ]. The onset of POTS may be precipitated by immunological stressors including surgery, viral infection, vaccination, trauma, pregnancy or psychological stress [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

Postural orthostatic tachycardia syndrome following open thoracoabdominal aortic aneurysm repair

Manuel

Fong

Mamo

et al. 2021

Journal of Surgical Case Reports

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Postural orthostatic tachycardia syndrome (POTS) is a variant of cardiovascular autonomic disorder characterised by an excessive heart rate on standing and orthostatic intolerance. We present a rare case of a 38-year-old man who underwent open repair of a thoracoabdominal aortic aneurysm for a chronic Stanford type B aortic dissection whose recovery was complicated by POTS. He received blood transfusions and was commenced on metoprolol, fludrocortisone and ivabradine with significant improvement in his symptoms. Correct assessment of postoperative tachycardia including postural telemetry is the key to identifying this condition and its successful management.

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Section: Discussionmentioning

confidence: 99%

Postural orthostatic tachycardia syndrome following open thoracoabdominal aortic aneurysm repair

Manuel

Fong

Mamo

et al. 2021

Journal of Surgical Case Reports

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“…Первые публикации, посвященные спиронолактону, появились более 50 лет назад [20]. В течение длительного времени работа над доказательной базой эффективности препарата была сосредоточена преимущественно на экспериментальных животных и исследованиях in vitro.…”

Section: ивабрадин снижает чсс почти линейно при интервалеunclassified

Damage to the Cardiovascular System in Patients with SARS-CoV-2 Coronavirus Infection. Part 1: Predictors of the Development of an Unfavorable Prognosis

Подзолков

Тарзиманова

Брагина

et al. 2022

Racionalʹnaâ farmakoterapiâ v kardiologii

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Aim. To evaluate the effect of sinus tachycardia and reduced left ventricular ejection fraction (LVEF) on the prognosis of patients with a verified diagnosis of a new coronavirus infection SARS-CoV-2.Material and methods. The study included 1,637 patients with a verified diagnosis of a new coronavirus infection SARS-CoV-2. The average age of the patients was 58.8±16.1 years. More than half of the patients admitted to the hospital had a history of cardiovascular diseases: hypertension was diagnosed in 915 (56%) patients, coronary artery disease – in 563 (34%), chronic heart failure – in 410 (25%). 294 (17.9%) patients suffered from diabetes mellitus. The unfavorable course of new coronavirus infection was assessed by the fact of being in the intensive care unit (ICU), the use of mechanical ventilation and death.Results. An unfavorable course of coronavirus infection was observed in 160 (9.8%) patients. Statistical analysis revealed that 341 (20.8%) patients with COVID-19 were diagnosed with sinus tachycardia, which required the appointment of pulse-reducing therapy. The occurrence of sinus tachycardia in patients with COVID-19 significantly increased the risk of death (odds ratio [OR] 1.248, confidence interval [CI] 1.038-1.499, p=0.018), increased the likelihood of mechanical ventilation use (OR 1.451, CI 1.168-1.803, p<0.001) and stay in the ICU (OR 1.440, CI 1.166-1.778, p<0.001).In 97 (5.9%) patients during hospital stay during echocardiography, a decrease in LVEF of less than 50% was diagnosed. A decrease in myocardial contractile function in patients with COVID-19 with high reliability increased the risk of death (OR 1.744, CI 1.348-2.256, p<0.001), increased the likelihood of using the mechanical ventilation (OR 1.372, CI 1.047-1.797, p=0.022) and stay in the ICU (OR 1.360, CI 1.077-1.716, p=0.010).Conclusion. The appearance of sinus tachycardia and reduced LVEF are in dependent predictors of the unfavorable course of COVID-19 in relation to factors such as death, the use of mechanical ventilation and the stay of patients in the ICU. Early pharmacological correction of cardiovascular lesions should be one of the goals of the management theese patients.

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“…6.-Tilt test o test de basculación, en pacientes con disautonomía como, por ejemplo, la presencia de síndrome de taquicardia postural ortostática (POTS) y síncopes (62).…”

Section: -Saturación De Oxígenounclassified

Conocimiento, reconocimiento e investigación colaborativa para el 2022 centrado en al covid-19 persistente

Ledo¹

2021

Med Gen Fam

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Ivabradine in Postural Orthostatic Tachycardia Syndrome: A Review of the Literature

Abstract: Tahir et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Cited by 19 publications

References 41 publications

Postural orthostatic tachycardia syndrome following open thoracoabdominal aortic aneurysm repair

Postural orthostatic tachycardia syndrome following open thoracoabdominal aortic aneurysm repair

Damage to the Cardiovascular System in Patients with SARS-CoV-2 Coronavirus Infection. Part 1: Predictors of the Development of an Unfavorable Prognosis

Conocimiento, reconocimiento e investigación colaborativa para el 2022 centrado en al covid-19 persistente

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