Iturins, a special class of pore-forming lipopeptides: biological and physicochemical properties

Lipopeptide C 17 Fengycin B Exhibits a Novel Antifungal Mechanism by Triggering Metacaspase-Dependent Apoptosis in Fusarium oxysporum

“…Among them, C 17 fengycin A and C 17 fengycin B displayed antifungal activity at the microgram per milliliter level. This result is consistent with previous reports that longer fatty acid chains in lipopeptide lead to stronger antifungal activity, possibly because antifungal compounds with longer acyl chains can be fully integrated into fungal cell membranes, whereas shorter acyl chains cannot . This is the first report highlighting that the longer the acyl chains of fengycin members, the stronger the antifungal activity.…”

Lipopeptide C 17 Fengycin B Exhibits a Novel Antifungal Mechanism by Triggering Metacaspase-Dependent Apoptosis in Fusarium oxysporum

“…Among them, C 17 fengycin A and C 17 fengycin B displayed antifungal activity at the microgram per milliliter level. This result is consistent with previous reports that longer fatty acid chains in lipopeptide lead to stronger antifungal activity, possibly because antifungal compounds with longer acyl chains can be fully integrated into fungal cell membranes, whereas shorter acyl chains cannot . This is the first report highlighting that the longer the acyl chains of fengycin members, the stronger the antifungal activity.…”

Antifungal potential of Bacillus vallismortis R2 against different phytopathogenic fungi

“…The spots I, II and III might be isoforms of fengycins as their Rf values on TLC and HPLC profile (Rt 6.87 min) were similar to those earlier reported in literature (Yanez-Mendizabel et al, 2012;Grover et al, 2010). These amphiphilic cyclic lipopeptide (CLP) compounds have been reported for their wide spectrum antifungal activity due to their interaction with biological membranes (Magnet-Dana & Peypoux, 1994;Stein, 2005). The TLC-based bioautography studies indicated varied antifungal potential of these biomolecules with the respective fungal pathogen.…”

Iturin and fengycin lipopeptides inhibit pathogenic Fusarium by targeting multiple components of the cell membrane and their regulative effects in wheat

“…Cell swelling is the most prominent morphological change observed in Fg following treatment with iturin and fengycin. While previous studies attributed this phenomenon primarily to ion leakage (Maget‐Dana et al, 1985; Maget‐Dana and Peypoux, 1994), our current findings suggest a more complex mechanism. The observed cell swelling appears to result from a combination of reduced protective efficacy of newly synthesized cell walls and increased intracellular osmotic pressure leading to water absorption (Figure 3).…”

Lipopeptide C 17 Fengycin B Exhibits a Novel Antifungal Mechanism by Triggering Metacaspase-Dependent Apoptosis in Fusarium oxysporum

“…Among them, C 17 fengycin A and C 17 fengycin B displayed antifungal activity at the microgram per milliliter level. This result is consistent with previous reports that longer fatty acid chains in lipopeptide lead to stronger antifungal activity, possibly because antifungal compounds with longer acyl chains can be fully integrated into fungal cell membranes, whereas shorter acyl chains cannot . This is the first report highlighting that the longer the acyl chains of fengycin members, the stronger the antifungal activity.…”

Antifungal potential of Bacillus vallismortis R2 against different phytopathogenic fungi

“…The spots I, II and III might be isoforms of fengycins as their Rf values on TLC and HPLC profile (Rt 6.87 min) were similar to those earlier reported in literature (Yanez-Mendizabel et al, 2012;Grover et al, 2010). These amphiphilic cyclic lipopeptide (CLP) compounds have been reported for their wide spectrum antifungal activity due to their interaction with biological membranes (Magnet-Dana & Peypoux, 1994;Stein, 2005). The TLC-based bioautography studies indicated varied antifungal potential of these biomolecules with the respective fungal pathogen.…”

Iturin and fengycin lipopeptides inhibit pathogenic Fusarium by targeting multiple components of the cell membrane and their regulative effects in wheat

“…Cell swelling is the most prominent morphological change observed in Fg following treatment with iturin and fengycin. While previous studies attributed this phenomenon primarily to ion leakage (Maget‐Dana et al, 1985; Maget‐Dana and Peypoux, 1994), our current findings suggest a more complex mechanism. The observed cell swelling appears to result from a combination of reduced protective efficacy of newly synthesized cell walls and increased intracellular osmotic pressure leading to water absorption (Figure 3).…”

Lipopeptide C 17 Fengycin B Exhibits a Novel Antifungal Mechanism by Triggering Metacaspase-Dependent Apoptosis in Fusarium oxysporum

“…Among them, C 17 fengycin A and C 17 fengycin B displayed antifungal activity at the microgram per milliliter level. This result is consistent with previous reports that longer fatty acid chains in lipopeptide lead to stronger antifungal activity, possibly because antifungal compounds with longer acyl chains can be fully integrated into fungal cell membranes, whereas shorter acyl chains cannot . This is the first report highlighting that the longer the acyl chains of fengycin members, the stronger the antifungal activity.…”

Antifungal potential of Bacillus vallismortis R2 against different phytopathogenic fungi

“…The spots I, II and III might be isoforms of fengycins as their Rf values on TLC and HPLC profile (Rt 6.87 min) were similar to those earlier reported in literature (Yanez-Mendizabel et al, 2012;Grover et al, 2010). These amphiphilic cyclic lipopeptide (CLP) compounds have been reported for their wide spectrum antifungal activity due to their interaction with biological membranes (Magnet-Dana & Peypoux, 1994;Stein, 2005). The TLC-based bioautography studies indicated varied antifungal potential of these biomolecules with the respective fungal pathogen.…”

Iturin and fengycin lipopeptides inhibit pathogenic Fusarium by targeting multiple components of the cell membrane and their regulative effects in wheat

“…Cell swelling is the most prominent morphological change observed in Fg following treatment with iturin and fengycin. While previous studies attributed this phenomenon primarily to ion leakage (Maget‐Dana et al, 1985; Maget‐Dana and Peypoux, 1994), our current findings suggest a more complex mechanism. The observed cell swelling appears to result from a combination of reduced protective efficacy of newly synthesized cell walls and increased intracellular osmotic pressure leading to water absorption (Figure 3).…”