Isotopic Renal Function Studies in Severe Hypothyroidism and after Thyroid Hormone Replacement Therapy

Karanikas, Georgios; Schütz, Matthias; Szabo, Monica; Becherer, Alexander; Wiesner, Karoline; Dudczak, Robert; Kletter, Kurt

doi:10.1159/000075628

Cited by 99 publications

(68 citation statements)

References 18 publications

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“…Nikkila showed that a moderate increase in serum triglycerides in hypothyroid patients [13]. Jaiprabhu [5] also reported about hyperlipidemia in hypothyroid patients [10]. All of these studies support our results.…”

Section: Resultssupporting

confidence: 89%

“…In general population a high prevalence of gout and hyperuricemia is found mainly due to impaired renal plasma flow and altered glomerular filtration rate [9]. However hyperuricemia is secondary in case of hypothyroid patients [10]. Some study revealed that in women, hypothyroid status was not associated with hyperuricemia or gout whereas hypothyroid is not associated with hyperuricemia in male also [11].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Correlation of Altered Lipid Profile, Uric Acid and Fasting Plasma Glucose Levels in Females with Hypothyroidism

Koley¹,

Sur²

2017

Endocrinol Metab Syndr

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Introduction: Hypothyroidism is a common endocrinal disorder in which thyroid gland does not produce enough thyroid hormones. The disease mainly occurs in female and its prevalence rises with age. Hypothyroidism may be the underlying cause of dyslipidemia and alteration of plasma glucose levels as thyroid hormones plays a key role in lipid and carbohydrate metabolism. It also helps in the growth and development of kidney; hence hypothyroidism may alter the uric acid level in serum due to altered secretion of uric acid at renal tubules.

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Section: Resultssupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Correlation of Altered Lipid Profile, Uric Acid and Fasting Plasma Glucose Levels in Females with Hypothyroidism

Koley¹,

Sur²

2017

Endocrinol Metab Syndr

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show abstract

“…In addition, hypo-or hyperthyroidism may affect renal tubular function, glomerular filtration rate (GFR) and proteinuria (7). Hypothyroidism has been associated with increased serum creatinine (Scr) and decreased GFR (8)(9)(10). On the other hand, thyrotoxicosis has been associated with increased GFR and renal blood flow (RBF) with a concomitant reduction of Scr (11,12).…”

Section: Introductionmentioning

confidence: 99%

The Thyroid and the Kidney: A Complex Interplay in Health and Disease

et al. 2014

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Thyroid hormones may directly affect the kidney and altered kidney function may also contribute to thyroid disorders. The renal manifestations of thyroid disorders are based on hemodynamic alterations or/and to direct effects of thyroid hormones. The renin-angiotensin system plays a crucial role in the cross-talk between the thyroid and the kidney. Hypothyroidism may be accompanied by an increase of serum creatinine and reduction of glomerular filtration rate (GFR), whereas hyperthyroidism may increase GFR. Treatment of thyroid disorders may lead to normalization of GFR. Primary and subclinical hypothyroidism and low triiodothyronine (T3) syndrome are common features in patients with chronic kidney disease (CKD). In addition low levels of thyroid hormones may predict a higher risk of cardiovascular and overall mortality in patients with end-stage renal disease. The causal nature of this correlation remains uncertain. In this review, special emphasis is given to the thyroid pathophysiology, its impact on kidney function and CKD and the interpretation of laboratorial findings of thyroid dysfunction in CKD.

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“…The clearance of OPG or its metabolism was reported to be under the influence of renal function (31) and creatinine clearance could be influenced by thyroid hormone (32). Although we have no data about the creatinine clearance, serum creatinine did not change significantly before and after L-T4 replacement therapy ( Table 3).…”

Section: Discussionmentioning

confidence: 81%

Increased levels of serum osteoprotegerin in hypothyroid patients and its normalization with restoration of normal thyroid function

Nagasaki¹,

Inaba²,

Jono³

et al. 2005

eur j endocrinol

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Hypothyroidism is associated with increased morbidity from cardiovascular disease, and an increase in serum osteoprotegerin (OPG) has recently been reported to be associated with the severity of coronary heart disease and cardiovascular mortality. The present study was designed to examine whether hypothyroidism causes an increase in serum OPG, and to determine whether levothyroxine (L-T4) replacement therapy might suppress serum OPG levels in hypothyroid patients. Fifty-three hypothyroid patients with chronic thyroiditis and age-and sex-matched normal control subjects were examined for the levels of serum OPG and plasma von Willebrand factor (vWF), a vascular injury marker. Thirty-seven of the hypothyroid patients were further monitored for changes in these markers during 1 year in a euthyroid state induced by L-T4 replacement therapy. Baseline OPG was significantly higher in hypothyroid patients than in normal controls (4.51^0.50 vs 3.72^0.23 pmol/l (mean^S.E.); P ¼ 0.0182). In multivariate analysis, baseline OPG was significantly associated with baseline levels of TSH (r ¼ 0.280, P ¼ 0.0162) and vWF (r ¼ 0.626, P , 0.0001). During one year of L-T4 replacement therapy, hypothyroid patients showed a significant decrease in OPG levels from 4.35^0.51 to 3.48^0.26 pmol/l (P ¼ 0.0166), a level comparable to normal controls. The change in serum OPG levels during L-T4 replacement therapy was significantly and independently associated in a negative fashion with baseline vWF (r ¼ 2 0.503, P ¼ 0.0014). This study suggested that the severity of hypothyroidism and vascular injury might have important independent roles in increasing the serum OPG level in hypothyroid patients. Furthermore, it was demonstrated that a sustained euthyroid state might have the potential to decrease the serum OPG level in hypothyroid patients and that the degree of vascular injury in the hypothyroid state is independently associated with a decrease in serum OPG during a 1-year normalization of thyroid function.

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Isotopic Renal Function Studies in Severe Hypothyroidism and after Thyroid Hormone Replacement Therapy

Cited by 99 publications

References 18 publications

Correlation of Altered Lipid Profile, Uric Acid and Fasting Plasma Glucose Levels in Females with Hypothyroidism

Correlation of Altered Lipid Profile, Uric Acid and Fasting Plasma Glucose Levels in Females with Hypothyroidism

The Thyroid and the Kidney: A Complex Interplay in Health and Disease

Increased levels of serum osteoprotegerin in hypothyroid patients and its normalization with restoration of normal thyroid function

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