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“…Food greatly decreases isoniazid bioavailability. 66 Oleanolic acid, a triterpenoid exists widely in food, medicinal herbs and other plants, has antimycobacterial activity against the Mycobacterium tuberculosis, when administered with isoniazid, it exerts synergistic effect. 67 High fat meals decrease the serum concentration of cycloserine, a bacteriostatic anti-tubercular drug and results in incomplete eradication of bacteria.…”
Section: Antitubercular Drugsmentioning
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“…Food greatly decreases isoniazid bioavailability. 66 Oleanolic acid, a triterpenoid exists widely in food, medicinal herbs and other plants, has antimycobacterial activity against the Mycobacterium tuberculosis, when administered with isoniazid, it exerts synergistic effect. 67 High fat meals decrease the serum concentration of cycloserine, a bacteriostatic anti-tubercular drug and results in incomplete eradication of bacteria.…”
Section: Antitubercular Drugsmentioning
“…However, isoniazid is a potent inhibitor of the CYP2C9, CYP2C19, and CYP2E1 isoenzymes 39. Examples of drugs whose metabolism is inhibited by isoniazid therapy include phenytoin, carbamazepine, diazepam, and triazolam.…”
Section: Adverse Events and Drug Interactions Of First-line Agentsmentioning
“…Isoniazid also potentiated acetaminophen hepatotoxicity (Crippin 1993; Nolan et al 1994). One case of increased warfarin toxicity (at 10 mg/day) including increased prothrombin time, hematuria, and bleeding gums caused by isoniazid has also been reported (Self et al 1999). Such interactions will require a reduced dose of coadministered drugs or replacement of drugs with similar efficacy while maintaining the isoniazid therapy.…”
Section: Clinical Management Of Mechanism-based Inhibition Of Cyp3a4mentioning