Isolation of hypotensive flavonoids from Chenopodium species growing in Egypt

Abstract

TLC investigation of the flavonoid fraction of Chenopodium murale L. revealed the presence of three components. The major was identified as kaempferol-3,7-dirhamnoside 1 (kaempferitrin; lespedin) through its MP, UV, IR, MS and NMR (H-H COSY and H-C. HECTOR) spectra. Testing the effect of compound 1 as well as the total flavonoid mixture on the rabbit cardiovascular system, showed dose-related hypotension and bradycardia. Compound 1 also produced a dose-related hypotension in genetically prone hypertensive rats. Compound 1 did not block ␣ 1 or ␤ 1 -adrenoceptors when tested using isolated guinea-pig aoric strip and atria, respectively. C. ambrosoides, C. murale, C. ficifolium and C. album revealed that the former contains the highest level. Quantification of 1 in

Acetylcholinesterase inhibition, antioxidant and identification of some chemical constituents of Phyllanthus atropurpureus cultivated in Egypt

“…The acid hydrolysis proved the presence of kaempferol as an aglycone which confirmed through it's UV and only rhamnose as sugar which were confirmed through the comparison with authentic samples in different solvents. Thus all the chromatographic and spectroscopic measurements confirmed the structure of compound PA-III as kaempferitrin (kaempferol-3,7-O-dirhamnoside) (Gohara, Elmazar, 1997).…”

Chenoalbuside: an antioxidant phenolic glycoside from the seeds of Chenopodium album L. (Chenopodiaceae)

“…It is a woody annual, widely distributed in Europe, North America and Asia (Bailey, 1977;GRIN Database, 2005). Previous phytochemical studies on this plant furnished the presence of aldehyde (Tahara et al, 1994;Maruta et al, 1995), alkaloids (Horio et al, 1993;Cutillo et al, 2004), apocarotenoids , fl avonoids (Gohar;Elmazar, 1997), phytoecdysteroids (Dinan, 1992, Dinan et al, 1998DellaGreca et al, 2005a), and an unusual xyloside (DellaGreca et al, 2005b). Various bioactivities, including antifungal (Tahara et al, 1994;Maruta et al, 1995), antipruritic, antinociceptive (Dai et al, 2002) and hypotensive (Gohar;Elmazar, 1997) properties, of crude extracts or isolated compounds from this plant were reported.…”

Bisresorcinols and Arbutin Derivatives from Grevillea banksii R. Br

“…The EtOAc and MeOH extracts of G. banksii were separated by HPLC and provided two new arbutin derivatives (1,4), seven new bis-resorcinols (6,(8)(9)(10)(11)(12)(13), and seven known compounds, kaempferitrin (2) [10], sagittatin A (3) [11], kaempferol 3-O-rhamnopyranosyl-7-O-rhamnopyranosyl-(1→4)-O-glucoside (5) [12], 5,5'-(4(Z)tetradecen-1,14-diyl)bisresorcinol (7) [13], grevillol (14), [14], 5-(8(Z)-heptadecenyl) resorcinol (15), and 5-(10(Z)-pentadecenyl)resorcinol, (16) [14]. 6: R 1 = -(CH 2 ) 3 -CH=CH-(CH 2 ) 7 ; R 2 = R 3 = H 7: R 1 = -(CH 2 ) 3 -CH=CH-(CH 2 ) 9 ; R 2 = R 3 = H 8: R 1 = -(CH 2 ) 3 -CH=CH-(CH 2 ) 9 ; R 2 = CH 3 , R 3 = H 9: R 1 = -(CH 2 ) 5 -CH=CH-(CH 2 ) 7 ; R 2 = R 3 = CH 2 CH=C(CH 3 )CH 2 OH 10: R 1 = -(CH 2 ) 5 -CH=CH-(CH 2 ) 7 ; R 2 = CH 2 CH=C(CH 3 )CH 2 OH R 3 = CH 2 CH=C(CH 3 )CH 2 OAc 11: R 1 = -(CH 2 ) 5 -CH=CH-(CH 2 ) 7 ; R 2 = CH 2 CH=C(CH 3 )CH 2 OH R 3 = CH 2 CH=C(CH 3 )CH 2 OAc The molecular formula of compound 1 was established as C 20 H 26 O 11 on the basis of its HRMS data.…”

“…The EtOAc and MeOH extracts of G. banksii were separated by HPLC and provided two new arbutin derivatives (1,4), seven new bis-resorcinols (6, 8-13), and seven known compounds, kaempferitrin (2) [10], sagittatin A (3) [11], kaempferol 3-O-rhamnopyranosyl-7-O-rhamnopyranosyl-(1→4)-O-glucoside (5) [12], 5,5'-(4(Z)tetradecen-1,14-diyl)bisresorcinol (7) [13], grevillol (14), [14], 5-(8(Z)-heptadecenyl) resorcinol (15), and 5-(10(Z)-pentadecenyl)resorcinol, ( 16) [14]. The molecular formula of compound 1 was established as C 20 H 26 O 11 on the basis of its HRMS data.…”