Isolation of a new bioactive cinnamic acid derivative from the whole plant of Viola <i>betonicifolia</i>

Muhammad, Naveed; Saeed, Muhammad; Adhikari, Achyut; Khan, Khalid; Khan, Haroon

doi:10.3109/14756366.2012.702344

Cited by 25 publications

(10 citation statements)

References 25 publications

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“…The new derivative of cinnamic acid in the form of off-white needles was sequestered from the whole plant of V. betonicifolia [36] and its structure was elucidated as 2,4-dihydroxy,5-methoxy-cinnamic acid by the exploitation of numerous spectroscopic techniques as High-resolution electron impact mass spectrometry (HREI-MS) and 1D and 2D NMR (Figure 2, 1 ). The isolated derivative of cinnamic acid was evaluated for antioxidant activity of which results were demonstrated that DPPH (diphenyl-2-picryl hydrazyl) free radicals were significantly scavenged by it through the exhibition of IC 50 = 124 ± 5.76 µM, which was further compared with standard employed antioxidants such as Vitamin C (IC 50 = 90 ± 0.56 µM) and α-tocopherol (IC 50 = 96 ± 0.46).…”

Section: Phytochemistrymentioning

confidence: 99%

A Comprehensive Review on Chemical and Pharmacological Potential of Viola betonicifolia: A Plant with Multiple Benefits

et al. 2019

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Viola betonicifolia (Violaceae) is commonly recognized as “Banafsha” and widely distributed throughout the globe. This plant is of great interest because of its traditional, pharmacological uses. This review mainly emphases on morphology, nutritional composition, and several therapeutic uses, along with pharmacological properties of different parts of this multipurpose plant. Different vegetative parts of this plant (roots, leaves, petioles, and flowers) contained a good profile of essential micro- and macronutrients and are rich source of fat, protein, carbohydrates, and vitamin C. The plant is well known for its pharmacological properties, e.g., antioxidant, antihelminthic, antidepressant, anti-inflammatory, analgesic, and has been reported in the treatment of various neurological diseases. This plant is of high economic value. The plant has potential role in cosmetic industry. This review suggests that V. betonicifolia is a promising source of pharmaceutical agents. This plant is also of significance as ornamental plant, however further studies needed to explore its phytoconstituents and their pharmacological potential. Furthermore, clinical studies are needed to use this plant for benefits of human beings.

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Section: Phytochemistrymentioning

confidence: 99%

A Comprehensive Review on Chemical and Pharmacological Potential of Viola betonicifolia: A Plant with Multiple Benefits

et al. 2019

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“…Muhammad et al [ 23 ] discovered that a derivative of cinnamic acid, the 2,4-dihydroxy-5-methoxy-cinaminic acid, isolated from the plant Viola betonicifolia moderately inhibited the formation of AGE, with IC 50 value of 355 μM. Note this is three times greater than the IC 50 of Onco A (87.88 ± 3.08 μM).…”

Section: Resultsmentioning

confidence: 99%

Oncocalyxone A Functions As an Anti-Glycation Agent In Vitro

Melo¹,

Santos

Lemos

et al. 2015

PLoS ONE

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Advanced glycation endproducts (AGE) are the result of post-translational changes to proteins, which ultimately compromise their structure and/or function. The identification of methods to prevent the formation of these compounds holds great promise in the development of alternative therapies for diseases such as diabetes. Plants used in traditional medicine are often rich sources of anti-glycation agents. Therefore, in this study, we investigated the anti-glycation activity of one such compound, Oncocalyxone A (Onco A). Using spectrofluorimetric techniques, we determined that Onco A inhibits AGE formation in a concentration-dependent manner. Its IC50 value (87.88 ± 3.08 μM) was almost two times lower than the standard anti-glycation compound aminoguanidine (184.68 ± 4.85 μM). The excellent anti-glycation activity of Onco A makes it an exciting candidate for the treatment of diseases associated with excessive accumulation of AGE. However, additional studies are necessary to identify its mechanism of action, as well as the in vivo response in suitable model organisms.

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“…In diabetes, oxidative stress has been found to be mainly due to an increased production of oxygen free radicals and a sharp reduction of anti-oxidant defenses (Oberley, 1988;Brownlee, 2001;Muhammad et al, 2012a). Hence, compounds with both hypoglycemic and anti-oxidative properties would be useful anti-diabetic agents (Brownlee, 2001).…”

Section: Discussionmentioning

confidence: 99%

Pharmacognostic and hypoglycemic studies of Achyranthus aspera L.

Ahmad¹,

Ibrar²,

Barkatullah³

et al. 2013

J. Pharmacognosy Phytother.

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In the present study, the ethanolic extract of Achyranthus aspera L. Leaves (EEA) were investigated for their pharmacognostic characteristics and hypoglycemic effects. The pharmacognosy of the plant was carried out using microscopic and macroscopic tools. Macroscopic studies revealed that the leaves were cauline, ramel, opposite, exstipulate, simple, sub-sessile, ovate, entire, acute, unicostate, reticulate, rough, coriaceous and hairy. The stem was erect, herbaceous, quadrangular, branched, solid, green and pubescent, while various internal parts were observed using powder drug for microscopic study. The hypoglycemic effect of the plant was studied in healthy normoglycemic rabbits. The EEA was tested in three doses (100, 150 and 200 mg/kg), and a dose dependent hypoglycemic effect was observed. The most significant hypoglycemic effect was observed against higher dose (200 mg/kg) which remained for 5 h while the hypoglycemic effect remained significant for 3 h against the lower dose. It was concluded that EEA has hypoglycemic properties and it is recommended for the treatment of diabetes mellitus II.

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Isolation of a new bioactive cinnamic acid derivative from the whole plant of Viola betonicifolia

Cited by 25 publications

References 25 publications

A Comprehensive Review on Chemical and Pharmacological Potential of Viola betonicifolia: A Plant with Multiple Benefits

A Comprehensive Review on Chemical and Pharmacological Potential of Viola betonicifolia: A Plant with Multiple Benefits

Oncocalyxone A Functions As an Anti-Glycation Agent In Vitro

Pharmacognostic and hypoglycemic studies of Achyranthus aspera L.

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