Isolation and structure elucidation of cyclopeptide alkaloids from the leaves of Heisteria parvifolia

Bitchi, Michel Boni; Magid, Abdulmagid Alabdul; Kabran, Faustin Aka; Yao-Kouassi, Philomène Akoua; Harakat, Dominique; Morjani, Hamid; Tonzibo, Felix; Voutquenne-Nazabadioko, Laurence

doi:10.1016/j.phytochem.2019.112081

Phytochemistry

2019

DOI: 10.1016/j.phytochem.2019.112081

|View full text |Cite

Isolation and structure elucidation of cyclopeptide alkaloids from the leaves of Heisteria parvifolia

Michel Boni Bitchi

Abdulmagid Alabdul Magid

Faustin Aka Kabran

et al.

Abstract: Highlights► Five undescribed cyclopeptide alkaloids were isolated from Heisteria parvifolia Sm.► Their structures were elucidated by 1D-, 2D-NMR and HR-ESI-MS analyses.► Their cytotoxicity against the chronic myeloid leukemia K562 cells was evaluated.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Picrachinentins A–F, 14-Membered Cyclopeptide Alkaloid-Type Burpitides with Uncommon N-Terminal Modifications from Picrasma chinensis and Their Neuroprotective Activity

Fan,

Song,

Zhang

et al. 2024

Org. Lett.

View full text Add to dashboard Cite

Picrachinentins A−F (1−6, respectively), six novel cyclopeptide alkaloid-type burpitides (CPABs), were isolated and fully elucidated from the EtOH extract of the stems and leaves of Picrasma chinensis. Structurally, compounds 1−6 have a 14membered paracyclophane ring system that was closed through an ether bond between the β-hydroxy amino acid and tyrosine and modified with a 4,5-methylenedioxybenzoyloxy (MDBz, 3 and 5) or hexanoyl (Hexa, 1, 2, 4, and 6) group at the N-terminus. Interestingly, this is the first report on the isolation and characterization of CPABs from plants of the Simaroubaceae family. In addition, all compounds showed a neuroprotective effect against H 2 O 2 -damaged SH-SY5Y cells. Compound 1 was further investigated for its neuroprotective activities using a 1-methyl-4phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease animal model, and it dramatically improved MPTPimpaired motor behavioral performance. Biochemical analysis revealed compound 1 restored the tyrosine hydroxylase expression in the striatum of the MPTP-damaged mouse brain, which demonstrates its protective effect on dopaminergic neurons.

show abstract

Picrachinentins A–F, 14-Membered Cyclopeptide Alkaloid-Type Burpitides with Uncommon N-Terminal Modifications from Picrasma chinensis and Their Neuroprotective Activity

Fan,

Song,

Zhang

et al. 2024

Org. Lett.

View full text Add to dashboard Cite

show abstract

The Current Scenario of Nature-Derived Cyclopeptides with Anticancer Potential (A Review)

Liu,

Wang

et al. 2024

Russ J Gen Chem

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Isolation and structure elucidation of cyclopeptide alkaloids from the leaves of Heisteria parvifolia

Abstract: Highlights► Five undescribed cyclopeptide alkaloids were isolated from Heisteria parvifolia Sm.► Their structures were elucidated by 1D-, 2D-NMR and HR-ESI-MS analyses.► Their cytotoxicity against the chronic myeloid leukemia K562 cells was evaluated.

Cited by 2 publications

References 29 publications

Picrachinentins A–F, 14-Membered Cyclopeptide Alkaloid-Type Burpitides with Uncommon N-Terminal Modifications from Picrasma chinensis and Their Neuroprotective Activity

Picrachinentins A–F, 14-Membered Cyclopeptide Alkaloid-Type Burpitides with Uncommon N-Terminal Modifications from Picrasma chinensis and Their Neuroprotective Activity

The Current Scenario of Nature-Derived Cyclopeptides with Anticancer Potential (A Review)

Contact Info

Product

Resources

About