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Cited by 91 publications
(32 citation statements)
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“…HeLa cells were infected with a purified stock ofthe WT strain ofvaccinia virus at a multiplicity of infection of 10 plaque-forming units/cell. The radioactively labeled methionine was added 2 h after infectior a time when host-cell protein synthesis was greatly inhibited (3,5,9,14,16,18,20). The cells were harvested 7 h after infection.…”
Section: Resultsmentioning
confidence: 99%
“…HeLa cells were infected with a purified stock ofthe WT strain ofvaccinia virus at a multiplicity of infection of 10 plaque-forming units/cell. The radioactively labeled methionine was added 2 h after infectior a time when host-cell protein synthesis was greatly inhibited (3,5,9,14,16,18,20). The cells were harvested 7 h after infection.…”
Section: Resultsmentioning
confidence: 99%
“…This enzyme is induced if cells are about to synthesize DNA either in the normal cell cycle [13-i5], or following viral infection [16]. Cellular and viral mutants lacking thymidine kinase show however, that the enzyme is, not indispensable for DNA replication [17,18].…”
Section: Discussionmentioning
confidence: 99%
“…Control LM(TK-) cells and self-fused LM(TK-) cells fail to incorporate [3H]dT into nuclear DNA (Dubbs and Kit, 1964). Incorporation of exogenous [3H]dT into nuclear DNA not only requires an active cytosol dT kinase, but also requires that the cell be synthesizing DNA, i.e.…”
Section: Cytosol Dt Kinase Activity Of Heterokaryons Of L M(tk-) and mentioning
confidence: 99%