Isolation and Characterization of the Estrogen Receptor in Human Skin*

Hasselquist, M. B.; Goldberg, Norman C.; Schroeter, Arnold L.; Spelsberg, Thomas C.

doi:10.1210/jcem-50-1-76

Cited by 124 publications

(60 citation statements)

References 48 publications

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“…Estrogen and androgen receptors are present in a variety of cell types in the skin, dermal fibroblasts as well as epidermal keratinocytes (42)(43)(44); hence these hormones may have numerous targets in this tissue. The mesenchyme plays an important role in lung morphogenesis, and estrogen and DHT have been shown to act on the pneumocyte indirectly, through an epithelial maturation factor secreted by the fibroblast (20,25).…”

Section: Discussionmentioning

confidence: 99%

Hormonal basis for the gender difference in epidermal barrier formation in the fetal rat. Acceleration by estrogen and delay by testosterone.

Hanley

Rassner²,

Jiang³

et al. 1996

J. Clin. Invest.

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Previous studies have shown that ontogeny of the epidermal permeability barrier and lung occur in parallel in the fetal rat, and that pharmacologic agents, such as glucocorticoids and thyroid hormone, accelerate maturation at comparable developmental time points. Gender also influences lung maturation, i.e., males exhibit delayed development. Sex steroid hormones exert opposite effects on lung maturation, with estrogens accelerating and androgens inhibiting. In this study, we demonstrate that cutaneous barrier formation, measured as transepidermal water loss, is delayed in male fetal rats. Administration of estrogen to pregnant mothers accelerates fetal barrier development both morphologically and functionally. Competent barriers also form sooner in skin explants incubated in estrogen-supplemented media in vitro. In contrast, administration of dihydrotestosterone delays barrier formation both in vivo and in vitro.

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Section: Discussionmentioning

confidence: 99%

Hormonal basis for the gender difference in epidermal barrier formation in the fetal rat. Acceleration by estrogen and delay by testosterone.

Hanley

Rassner²,

Jiang³

et al. 1996

J. Clin. Invest.

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“…Another hypothesis is that majority of women going for CABG are postmenopausal, and decreased estrogen levels in postmenopausal females may impair wound healing in addition to increasing the risk of coronary artery disease (CAD) after menopause. Estrogen receptors have been tagged in various skin cells, 23 and administration of estrogen has been found to promote the release of platelet-derived growth factor alpha and to augment fibroblastic and myofibroblastic wound contraction. 24 …”

Section: Female Sexmentioning

confidence: 99%

Saphenous vein harvest wound complications: risk factors, identification, prevention, and management

Siddiqi¹

2016

CWCMR

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Coronary artery bypass grafting is a commonly performed surgery worldwide that gives good results. Great saphenous vein is used as a conduit for bypass in over 95% cases. The harvesting technique has remained unchanged over the years. However, wound complications from harvesting the great saphenous vein by open method can be a major source of postoperative morbidity. With the objective of preventing major complications, identification of risk factors for saphenous vein harvest site infection is important. It is imperative to develop approaches that prevent infection and to allow for early recognition of patients who are at high risk and who may need more watchful monitoring so as to prevent development of wound complications. It is desirable to assess the patient completely, delineate the anatomy of peripheral vessels particularly in a patient with associated peripheral vascular disease, identify the best site to perform the saphenous vein harvest incision, employ a meticulous surgical technique, recognize complications early, and start the recommended treatment without delay. The aim of this paper is to identify the risk factors for saphenous vein harvest site complications and their identification, prevention, and management.

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“…Secondly, since the majority of female patients undergoing CABG procedures were postmenopausal, it is possible that decreased estrogen level may also impair leg wound healing in addition to its deleterious effect on cardiovascular disease. Estrogen receptors have been identified in various cells of human skin [10], and administration of estrogen has been shown to increase the release of platelet-derived growth factor alpha and to stimulate fibroblastic and myofibroblastic wound contraction [11]. However, information on the effect of hormone replacement on wound healing is still lacking.…”

Section: Discussionmentioning

confidence: 99%

Fatores de risco que afetam as complicações da dissecação da veia safena na revascularização cirúrgica do miocárdio

Abbaszadeh¹,

Arabnia²,

Rabbani³

et al. 2008

Rev Bras Cir Cardiovasc

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Fatores de risco que afetam as complicações da dissecação da veia safena na revascularização cirúrgica do miocárdioThe risk factors affecting the complications of saphenous vein graft harvesting in aortocoronary bypass surgery Abstract Objective: Problem of wound healing is commonly observed after coronary artery bypass graft procedures. Our aim is to determine the prevalence and the predictors of saphenous vein harvesting complication after coronary revascularization procedures.Methods: After institutional ethical committee review and approval, a retrospective review was undertaken of 4029 bypass procedures with saphenous vein graft performed over a period of six years is conducted. Thirteen risk factors for those who developed major leg wound complications were analyzed and compared with the entire cohort of patients, undergoing similar bypass procedures during the same period.Results: Lower extremity wound complications occurred in 68 patients (1.7%), 43 of them required additional surgical interventions. There were 17 wound debridements, nine skin grafts, one angioplasty, 11 fasciotomies, three vascular procedures, and two free tissue transfers. Of 13 variables evaluated by multivariate analysis, female gender, BMI, use of internal thoracic artery graft, peripheral vascular disease, the use of postoperative intraaortic balloon pump and preexisting hyperlipidemia were identified as significant independent predictors of major leg wound complications (p<0.05).Conclusions: Rev Bras Cir Cardiovasc 2008; 23(3): 317-322

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Isolation and Characterization of the Estrogen Receptor in Human Skin*

Cited by 124 publications

References 48 publications

Hormonal basis for the gender difference in epidermal barrier formation in the fetal rat. Acceleration by estrogen and delay by testosterone.

Hormonal basis for the gender difference in epidermal barrier formation in the fetal rat. Acceleration by estrogen and delay by testosterone.

Saphenous vein harvest wound complications: risk factors, identification, prevention, and management

Fatores de risco que afetam as complicações da dissecação da veia safena na revascularização cirúrgica do miocárdio

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