Isolation and characterization of an anti-HSV polysaccharide from Prunella vulgaris

Xu, Hong‐Xi; Lee, Spencer H. S.; Lee, Song F.; White, Robert L.; Blay, Jonathan

doi:10.1016/s0166-3542(99)00053-4

Cited by 109 publications

(70 citation statements)

References 18 publications

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“…It is traditionally used for eye pain, inflammation, headache, dizziness, sore throat and wound healing [1]. P. vulgaris is known as selfheal; contains several active components, including oleanolic acid, betulinic acid, ursolic acid, flavonoids and rosmarinic acid [2][3][4]. Some pharmacological activities such as the immunmodulatory effect [5,6], anti-viral activity against HSV-1, HSV-2 [7,8], HIV [9,10], antioxidant activity [1,11] and anti hyperglycemic action [8] were confirmed.…”

Section: Introductionmentioning

confidence: 99%

The antimicrobial activity of Prunella vulgaris extracts

Mahboubi¹,

Mahboubi

Kazempour³

2015

Herba Polonica

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S u m m a r yPrunella vulgaris (Labiatae family) or self-heal is traditionally used for different ailments such as eye pain and inflammation, headache, dizziness, sore throat and wound healing. Total phenolic and total flavonoid contents of extracts (methanol, ethanol and aqueous) were determined by a spectrophotometer. The antimicrobial activity was evaluated by micro broth dilution assay. The total phenolic content of P. vulgaris extracts were higher in aqueous extract (156.5 mg GAC/g) followed by ethanol extract and methanol extract. The TFC content of P. vulgaris methanol extract (82.8 mg QE/g) was higher than ethanol extract (22.7 mg QE/g) and aqueous extract (16.2 mg QE/g). The antimicrobial activity of methanol or ethanol extracts was higher than aqueous extract from P. vulgaris. The sensitivity of microorganisms to different extracts is related to type of pathogens. There is no positive relation between total phenolic content and its antimicrobial activity. Prunella vulgaris ethanolic extract as a source of phenolic and flavonoid contents can be used as an antimicrobial agent.

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Section: Introductionmentioning

confidence: 99%

The antimicrobial activity of Prunella vulgaris extracts

Mahboubi¹,

Mahboubi

Kazempour³

2015

Herba Polonica

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“…Previous phytochemical studies on the bioactive components of P. vulgaris have reported the isolation of triterpenoids, phenolics, fl avonoids, tannins, caff eic acids, the anionic polysaccharide prunelline and essential oils (Lamaison et al, 1991;Xu et al, 1999;Wang et al, 2000;Ryu et al, 2000;He et al, 2007;Zhang et al, 2011). Because secondary metabolites are particularly prone to qualitative and quantitative variations depending on factors such as genetic drift, physiological conditions, season and harvesting time, as well as analytical methods and sample preparation techniques, numerous investigations concerning the influence of the aforementioned factors have been conducted Wu et al, 2010;Liao et al, 2010;Chen et al, 2011;Wang et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Variation in concentrations of major bioactive compounds in Prunella vulgaris L. related to plant parts and phenological stages

Chen

Zhu

et al. 2012

Biol. Res.

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Prunella vulgaris L. (Labiatae) contains a variety of structurally diverse natural products, primarily rosmarinic acid (RA), ursolic acid (UA) and oleanolic acid (OA), which possess a wide array of biological properties. In the present study, P. vulgaris was harvested at three developmental stages (vegetative, full-flowering and mature-fruiting stages), dissected into stem and leaf tissues and assayed for chemical contents using high performance liquid chromatography. Signifi cant changes in the concentrations of the major secondary metabolites (RA, UA and OA) were observed at the diff erent development stages. The highest concentrations of RA, UA and OA were found at the full-flowering stage (15.83 mg/g dry weight (DW) RA, 1.77 mg/g DW UA and 0.65 mg/g DW OA). Among the diff erent aerial parts of the plant, the concentrations of RA, UA and OA were higher in the leaves than in the stems at the diff erent developmental stages. These results suggest that the full-flowering stage is characterized by the highest concentrations of bioactive compounds. Therefore, this stage may be the optimum point for harvesting P. vulgaris plants. In additional, the leaves of P. vulgaris demonstrated higher RA, UA and OA concentrations than the stems, suggesting higher utilization potential.

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“…The mode of action appears to be different from other anionic carbohydrates, such as heparin [56]. The aqueous and methanol extractions of P. vulgaris used as anti-fever remedies in China were screened for their in vitro inhibition on human immunodeficiency virus type-1 protease (HIV-1 PR) [57].…”

Section: Antibacterial and Antivirus Activitiesmentioning

confidence: 99%

Research Progress on the Chemistry and Pharmacology of Prunella vulgaris Species

Ge¹,

Wang²,

Zhang³

et al. 2014

OALib

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An exhaustive literature survey on the secondary metabolites of widely distributed Prunella vulgaris L. species has been carried out. Triterpenoids, sterols, phenylpropanoids, flavonoids, coumarins, fatty acids, volatile oils and carbohydrates along with some other compounds, have been reported from this species. Many of these compounds have been found to possess significant biological properties, including antihypertensive activity, anticancer activity, anti-lipidemic activity, antibacterial and antivirus activities, anti-inflammatory activities, hypoglycemic effects, heptaprotective effects, antineoplastic activities, etc. P. vulgaris might offer a rich natural source with relative cheap price for developing new anti-neoplastic drugs.

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Isolation and characterization of an anti-HSV polysaccharide from Prunella vulgaris

Cited by 109 publications

References 18 publications

The antimicrobial activity of Prunella vulgaris extracts

The antimicrobial activity of Prunella vulgaris extracts

Variation in concentrations of major bioactive compounds in Prunella vulgaris L. related to plant parts and phenological stages

Research Progress on the Chemistry and Pharmacology of Prunella vulgaris Species

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