Isolated mitral valve prolapse is an independent predictor of aortic root size in a general population

Abstract

Isolated MVP is an independent predictor of greater AoR size in a large population with otherwise normal echocardiographic parameters.

Classic Mitral Valve Prolapse Causes Enlargement in Left Ventricle Even in the Absence of Significant Mitral Regurgitation

“…8 In their study, differently from ours, Matos-Souza et al included not only classic MVP patients but also nonclassic MVP patients. They also reported that there was no difference between MVP and control groups in terms of LV mass index.…”

“…The thickening in the valves together with the redundancy of leaflets are the echocardiographical indicators of myxomatous degeneration which is the histopathological diagnosis of MVP. 8 Although our study did not include the histopathological data, we demonstrated that the myocardium and/or fibrous skeletal structure of the heart might be additionally involved in the patients with classic bileaflet MVP in which myxomatous degeneration was proved with echocardiography. 3 In myxomatous degeneration, proteoglycans are histopathologically accumulated in spongiosa part and the structural collagen changes occur in chordas and in all layers of the valve.…”

“…It may be caused by histological abnormalities of valves and geometric disparities between the left ventricle (LV) and valvular annulus. 8 Especially in the classic bileaflet MVP, which is characterized by prominent leaflet thickening and redundancy, histopathological and geometrical valve changes may be related with the pathological and/or geometrical changes in the myocardium and the fibrous skeletal structure of the heart. 3 The underlying mechanism of myxomatous degeneration of mitral apparatus is still unknown.…”

“…7 Furthermore, it has been identified that aortic root is enlarged in patients with isolated primary MVP. 8 Especially in the classic bileaflet MVP, which is characterized by prominent leaflet thickening and redundancy, histopathological and geometrical valve changes may be related with the pathological and/or geometrical changes in the myocardium and the fibrous skeletal structure of the heart. 9,10 This condition may also lead to enlargement of the LV independently from the mitral regurgitation (MR).…”

Left ventricular function in mitral valve prolapse and severe mitral regurgitation

“…Известно, что миксома-тозный ПМК является независимым предиктором ее большего размера в общей популяции с неизме-ненными в остальном эхокардиографическими показателями [34].…”