Isolated intracranial Rosai Dorfman disease

Krishnamoorthy, Venkidesh; Parmar, Chirag; Panikar, Dilip

doi:10.4103/0028-3886.82770

Cited by 12 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Microscopically, lymph nodes show dilated sinuses containing foamy histiocytes and plasma cells. Many of these histiocytes contain intact hematopoietic cells, mostly lymphocytes within their cytoplasm, a phenomenon known as emperipolesis 2,3,9 . These histiocytes are positive for S-100 protein and CD-68 and negative for CD1a based on immunohistochemical examination 2,7,10 .…”

Section: Discussionmentioning

confidence: 99%

Isolated intracranial Rosai Dorfman Disease without nodal involvement.

Aziz¹,

Raja²,

Khimani³

et al. 2019

Int. j. endorsing health sci. res.

View full text Add to dashboard Cite

Background: Rosai Dorfman disease (RDD) is a benign lymphohistiocytosis that often involves lymph nodes and present as massive painless lymphadenopathy with sinus histiocytosis. Usually systemic involvement and with rare intracranial and extremely rarely intracranial involvement without the involvement of lymphadenopathy. Case Presentation: We presented a case of 60 years old female with seizures and left side weakness and no lymphadenopathy. The magnetic resonance imaging (MRI) revealed contrasting right frontal homogenously enhancing convexity mass. Management & Results: The patient was kept on antiepileptic medications but soon presented with fits and slight expansion in frontal mass. Surgery was performed (right frontal craniotomy), the mass was surgically resected and biopsy indicated RDD. Conclusion: By now only seven of such cases are reported and prognosis of the disease is not poor if surgically treated however other measures including radiotherapy, chemotherapy, steroids are not very effective for treating the disease. And due to the rarity of disease suspicion of such disease should always be kept as a key differential in homogenously enhancing lesions with dural involvement with or without lymphadenopathy.

show abstract

Section: Discussionmentioning

confidence: 99%

Isolated intracranial Rosai Dorfman Disease without nodal involvement.

Aziz¹,

Raja²,

Khimani³

et al. 2019

Int. j. endorsing health sci. res.

View full text Add to dashboard Cite

show abstract

“…It usually presents as bilateral painless cervical lymphadenopathy. Intracranial RDD occurs in less than 5% of the cases and the dura is the most common site of involvement (5,9). Systemic symptoms may be absent in isolated intracranial disease.…”

Section: Discussionmentioning

confidence: 99%

“…Extranodal involvement occurs with lymphadenopathy in 43% of the cases. Isolated extranodal disease occurs in about 23% of the cases and affects skin (12%), paranasal sinuses (11%), soft tissues (9%), bone (9%), salivary glands (5%), central nervous system (5%), oral cavity (3%), kidney (2%), lower respiratory tract (2%), larynx (1%) and orbit (5-10%) (5,8,9).…”

Section: Introductionmentioning

confidence: 99%

Isolated intracranial rosai-dorfman disease involving the meninges: report of a rare case.

Bhat

Kupanur²,

Geethamani³

2014

Turkish Neurosurgery

View full text Add to dashboard Cite

Sinus histiocytosis with massive lymphadenopathy or Rosai-Dorfman disease (RDD) is a reactive condition of unknown etiology, characterised by a proliferation of histiocytes exhibiting emperipolesis of lymphocytes and plasma cells. It usually presents as bilateral painless cervical lymphadenopathy. Extranodal RDD without nodal disease is seen in 23% of the cases. Intracranial RDD occurs in less than 5% of the total number of patients with extranodal disease. Isolated intracranial RDD in the absence of nodal disease is exceptional.We report a case of Rosai-Dorfman disease with isolated intracranial involvement. A 38-year-old man came with long-standing headache and the magnetic resonance imaging (MRI) scan showed features of meningioma. The histopathology revealed sheets of histiocytes displaying emperipolesis. These histiocytes were S100 positive but CD1a and epithelial membrane antigen negative.KEywOrds: Emperipolesis, Extranodal Rosai-Dorfman disease, Intracranial Rosai-Dorfman disease, Sinus histiocytosis with massive lymphadenopathy ÖZMasif lenfadenopatili sinüs histiyositozu veya Rosai-Dorfman hastalığı (RDD) bilinmeyen etiyolojili reaktif bir durumdur ve lenfositler ve plazma hücrelerinin emperipolezisini gösteren bir histiosit proliferasyonuyla karakterizedir. Genellikle bilateral ağrısız servikal lenfadenopati olarak ortaya çıkar. Nodal hastalık olmadan ekstranodal RDD olguların %23'ünde görülür. İntrakraniyal RDD, ekstranodal hastalıklı hastaların %5'inden azında görülür. Nodal hastalık bulunmadığında izole intrakraniyal RDD çok nadirdir.İzole intrakraniyal tutulumlu bir Rosai-Dorfman hastalığı olgusu sunuyoruz. 38 yaşında bir erkek, uzun süreli baş ağrısı ile başvurdu ve manyetik rezonans görüntüleme (MRG) taraması menenjiyom bulguları gösterdi. Histopatolojide emperipolez gösteren histiyosit tabakaları görüldü. Bu histiyositler S100 pozitif ama CD1a ve epitelyal membran antijeni negatifti.ANAhTAr sÖZCÜKlEr: Emperipolez, Ekstranodal Rosai-Dorfman hastalığı, İntrakraniyal Rosai-Dorfman hastalığı, Masif lenfadenopatili sinüs histiyositozu

show abstract

“…Isolated central nervous system (CNS) involvement is extremely rare (2,6,4,10,13,15, [17][18][19][21][22][23]28,33,35,36,38,46). In a large series of RDD including 200 cases there were only 3 cases with intracranial manifestations (9).…”

Section: Discussionmentioning

confidence: 99%

Isolated intracranial rosai-dorfman disease: report of 2 cases and a review of the literature

Abdel-Razek

Matter²,

Azab³

et al. 2011

Turkish Neurosurgery

View full text Add to dashboard Cite

Rosai-Dorfman disease (RDD) is a rare but well-recognized idiopathic histioproliferative disease affecting the systemic lymph nodes. It is characterized by an unusual proliferation of histiocytic cells. Intracranial localization is a rare manifestation of RDD. The clinical and radiological differentiation from meningiomas is difficult, and can only be achieved after histological examination. This entity should be considered in the differential diagnosis of dural based lesions mimicking meningioma. We report 2 cases of isolated intracranial RDD. The first patient had a large frontal lesion in addition to smaller multiple intracranial lesions. The second patient had only one parasagittal lesion. The diagnosis was confirmed on histopathological examination after surgical excision. The pertinent literature is also reviewed.

show abstract

Isolated intracranial Rosai Dorfman disease

Cited by 12 publications

References 0 publications

Isolated intracranial Rosai Dorfman Disease without nodal involvement.

Isolated intracranial Rosai Dorfman Disease without nodal involvement.

Isolated intracranial rosai-dorfman disease involving the meninges: report of a rare case.

Isolated intracranial rosai-dorfman disease: report of 2 cases and a review of the literature

Contact Info

Product

Resources

About