Isohumulones modulate blood lipid status through the activation of PPARα

Shimura, Masako; Hasumi, Akiko; Minato, Toshiko; Hosono, Mayu; Miura, Yutaka; Mizutani, S; Kondö, Keiji; Oikawa, Shinichi; Yoshida, Aruto

doi:10.1016/j.bbalip.2005.06.008

Cited by 23 publications

(32 citation statements)

References 43 publications

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“…There was no significant difference in body weight between the two groups. Consistent with previous reports (10,36), there was a significant reduction in TG and a significant increase in TC in WT mice following treatment with fenofibrate ( Table 1).…”

Section: Resultssupporting

confidence: 81%

Fenofibrate promotes ischemia-induced revascularization through the adiponectin-dependent pathway

Li¹,

Shibata²,

Maruyama³

et al. 2010

American Journal of Physiology-Endocrinology and Metabolism

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Recent clinical trials demonstrated that PPAR␣ agonist fenofibrate reduces cardiovascular events, including limb amputation in people with type 2 diabetes. Here, we investigated whether fenofibrate modulates the revascularization process in a mouse model of hindlimb ischemia. Treatment with fenofibrate led to acceleration of revascularization of ischemic hindlimb relative to the contralatereal limb in wild-type (WT) mice, as measured by laser Doppler blood flow and capillary density analyses. Treatment of WT mice with fenofibrate increased the serum levels of adiponectin, which has protective actions on the vasculature. Of importance, fenofibrate had no effects on the revascularization in ischemic limbs of adiponectin-deficient (APN-KO) mice. Fenofibrate stimulated the phosphorylation of AMPK and eNOS in the ischemic muscles in WT mice but not in APN-KO mice. AMPK inhibitor compound C suppressed fenofibrate-induced increase in limb perfusion and AMPK phosphorylation in ischemic muscle in WT mice without affecting adiponectin levels. NOS inhibitor L-NAME also blocked the increased blood flow of ischemic limbs in fenofibratetreated WT mice. Our observations suggest that fenofibrate could promote revascularization in response to ischemia through adiponectin-dependent AMPK signaling.angiogenesis; endothelial nitric oxide synthase

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Section: Resultssupporting

confidence: 81%

Fenofibrate promotes ischemia-induced revascularization through the adiponectin-dependent pathway

Li¹,

Shibata²,

Maruyama³

et al. 2010

American Journal of Physiology-Endocrinology and Metabolism

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“…Their published study included the results of a small double blind, placebo controlled pilot trial in diabetic humans demonstrating a significant reduction in fasting blood glucose and hemoglobin A1c after 8 weeks of intervention in the isohumulone treated group versus the control group. Subsequent studies reported by this Japanese group indicated that the hops-derived isohumulones reduced elevated triglycerides associated with insulin resistance, and raised HDL cholesterol levels while reducing liver fat stores in diabetic animal models [19,20]. In a companion study this same group reported that the administration of isohumulones prevented high fat diet-induced obesity in the C57BL/6N mouse model [21].…”

Section: Influence Of Hops Isohumulones (Iso-alpha Acids) On Inflammamentioning

confidence: 92%

Isohumulones from hops (Humulus lupulus) and their potential role in medical nutrition therapy

Bland¹,

Minich²,

Lerman³

et al. 2015

PharmaNutrition

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“…26 C57BL/6N mice fed a diet with 1% isohumulone showed hepatomegaly accompanied by reduced plasma triglyceride levels. 27 Isohumulones also possess anti-inflammatory and anticancer activities. 28 They can inhibit LPS-induced iNOS activity in RAW 264.7 macrophages at 6-18 lg/ml and induce NAD(P)H:quinone reductase activity at 1-10 lg/ml in murine hepatoma cells with cytotoxicity seen at an LD 50 > 20 lg/ml.…”

Section: Introductionmentioning

confidence: 99%

Comparative In Vitro Cytotoxicity of 20 Potential Food Ingredients in Canine Liver, Kidney, Bone Marrow-Derived Mesenchymal Stem Cells, and Enterocyte-like Cells

Monteiro‐Riviere

OrtegaMaria

ChoiKyoungju

et al. 2015

Applied In Vitro Toxicology

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To begin development of a mechanistically relevant humane alternative platform for safety assessment of dog food ingredients, comparative in vitro cytotoxicity of 20 ingredients was assessed in four canine cell types relevant for toxicity assessments. Previously, we described the toxicity of 13 compounds (clove leaf oil, eugenol, guanosine monophosphate [GMP], GMP plus inosine monophosphate, sorbose, ginger root extract, cinnamon bark oil, cinnamaldehyde, thyme oil, thymol, lemon grass oil, xylitol, and citric acid) using in vitro primary canine cell culture models for liver, kidney, bone marrow-derived mesenchymal stem cells (BMSC), and enterocyte-like cells (ELC). In this report, dose-response cytotoxicity studies and LC 50 using alamar blue assays are reported for seven additional compounds: denatonium benzoate, eucalyptol, hexahydroisohumulone, tetrahydroisohumulone, green tea catechin extract, epigallocatechin gallate, and sodium copper chlorophyllin. Data across 20 compounds were compared between different cell types and responses were not parallel, precluding the use of a single cell line for in vitro ingredient hazard assessment. Hepatocytes were most resistant to all compounds, consistent with their xenobiotic detoxification functions. BMSC and ELC showed an increase in sensitivity to the essential oils eucalyptol, eugenol, and thymol compared to renal cells and hepatocytes. These studies provide a baseline of acute cytotoxicity of 4 canine cell types to 20 different food components that begin to illustrate how such an in vitro panel could be used for hazard assessment.

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Isohumulones modulate blood lipid status through the activation of PPARα

Cited by 23 publications

References 43 publications

Fenofibrate promotes ischemia-induced revascularization through the adiponectin-dependent pathway

Fenofibrate promotes ischemia-induced revascularization through the adiponectin-dependent pathway

Isohumulones from hops (Humulus lupulus) and their potential role in medical nutrition therapy

Comparative In Vitro Cytotoxicity of 20 Potential Food Ingredients in Canine Liver, Kidney, Bone Marrow-Derived Mesenchymal Stem Cells, and Enterocyte-like Cells

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