Isoflavonoids

Dewick, Paul M.

doi:10.1007/978-1-4899-2915-0_10

Cited by 37 publications

(8 citation statements)

References 275 publications

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“…238 UDP-glucose: isoflavone 7-O-glucosyltransferase (UGT88E3) was then purified from soybean seedlings, and its cDNA was cloned. 253 After the formation Scheme 20 of isoflavone skeleton, pterocarpans are constructed by several reactions including oxidation, reduction, and dehydrative cyclization (Scheme 21). 240 Naturally, all these isoflavonoid-specific glycosyltransferases (GTs) are classified as plant secondary product glycosyltransferases (PSPGs) of group 1 GT family.…”

Section: 1 Biosynthesis Of Isoflavones In Leguminous Plantsmentioning

confidence: 99%

Plant Phenolics: Phenylpropanoids

Ayabe¹,

Uchiyama²,

Aoki³

et al. 2010

Comprehensive Natural Products II

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Section: 1 Biosynthesis Of Isoflavones In Leguminous Plantsmentioning

confidence: 99%

Plant Phenolics: Phenylpropanoids

Ayabe¹,

Uchiyama²,

Aoki³

et al. 2010

Comprehensive Natural Products II

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“…In comparison to the flavonoids (2-phenylchromans), which are found widely in higher plants, the isoflavonoids appear in a limited occurrence of taxon, probably owing to the limited occurrence of IFS enzyme, being confined essentially to the subfamily Papilionoideae (Lotoideae) of the leguminosae (Klejdus et al 2005a;Veitch 2007Veitch , 2009). There are however, occasional examples of their occurrence in the subfamily Caesalpinioidae, and in other families (Rosaceae, Moraceae, Amaranthaceae, Podocarpaceae, Chenopodiaceae, Cupressaceae, Iridaceae, Myristicaceae and Stemonaceae) together with some reports of their isolation from microbial sources (Dewick 1982;Reynaud et al 2005).…”

Section: Introductionmentioning

confidence: 98%

“…The basic structure of isoflavonoids is illustrated in Fig. 1 (Dewick 1982). Around 840 new isoflavonoids have been reported over last 15 years indicating the increasing interest in search for the natural isoflavonoids (Sharma and Ramawat 2013;Veitch 2013).…”

Section: Introductionmentioning

confidence: 98%

Phytochemical analysis of isoflavonoids using liquid chromatography coupled with tandem mass spectrometry

et al. 2015

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Isoflavonoids are the biologically active secondary metabolites of plants that are being used for several health promoting and restoring effects mediated through different pathways. Isoflavonoids are structurally similar to estrogens due to which also known as phytoestrogens and have shown potent estrogenic and anti-estrogenic activity. Association with large biological activity lead to the need of rapid, sensitive and precise quantitation of different isoflavonoids in different plant extracts, food materials and biological matrices as the biological activities mainly depends on the quantities and nature of isoflavonoids present in them. The characterisation, standardisation and quantification of herbal extracts or food products require techniques that are highly selective, sensitive and also provide mass measurement precisions and structural information. Liquid chromatography with tandem mass spectroscopy has made it possible to analyse and characterize several constituents and their metabolites in a single run along with high selectivity and sensitivity. In this review, we have summarised the application of LC-MS/MS for the identification and quantification of isoflavonoids reported for various plant extracts and food products along with their general extraction procedures and factors affecting extraction providing a view towards the conditions used for their analysis. The most suitable and widely acceptable extraction solvent system for the isoflavonoids is methanol or ethanol in combination with water ranging from 40 to 60 % organic solvent based on the type of tissues and the isoflavonoids to be extracted by different extraction techniques. ESI ionization with Q-TOF MS was the most useful detection system for the characterisation and quantification of the diverse isoflavonoids with molecular insights.

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“…1) Genistein is a secondary metabolite belonging to the isoflavone family, which evokes great interest because of its pleiotropic biological activity and possible applications in human cancer therapy and chemoprevention [10][11][12][13]. (Fig.…”

Section: Introductionmentioning

confidence: 99%

The Mechanisms of Anticancer Agents by Genistein and Synthetic Derivatives of Isoflavone

Luo²,

Qiao³

2012

MRMC

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Genistein is the most abundant isoflavone in soybeans. It has exhibited diverse biological activities, among these, its anticancer effects is most noteworthy. Through regulating critical cell cycle genes, genistein can inhibit cancer cell growth in vivo and in vitro. It has been reported that genistein can inhibit activation of NF-κB and Akt signaling pathways to induce cell apopt1osis, both pathways are well known for their function to maintain a balance between cell survival and apoptosis. In order to find out more outstanding anticancer isoflavone agents, against cancers extended synthesis of genistein derivatives has been carried out. Some of these synthetic compounds demonstrated higher anticancer activity with lower doses. Based on these results, genistein and its synthetic derivatives may be an emerging new type of anticancer agents.

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Isoflavonoids

Cited by 37 publications

References 275 publications

Plant Phenolics: Phenylpropanoids

Plant Phenolics: Phenylpropanoids

Phytochemical analysis of isoflavonoids using liquid chromatography coupled with tandem mass spectrometry

The Mechanisms of Anticancer Agents by Genistein and Synthetic Derivatives of Isoflavone

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