Ishige okamurae ameliorates hyperglycemia and insulin resistance in C57BL/KsJ-db/db mice

Min, Kweon Sik; Kim, Hak-Ju; Jeon, You‐Jin; Han, Ji-Sook

doi:10.1016/j.diabres.2011.03.018

Cited by 51 publications

(41 citation statements)

References 30 publications

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“…In previous studies, pigments of brown algae have been reported to exhibit various biological activities such as antioxidant, anti-inflammation and anti-tumor effect (Budhiyanti, Raharjo, Marseno, & Lelana, 2012). The extract of Ishige okamurae has shown various biological activities in vitro and in vivo such as antioxidant, anti-diabetes and neuro-protective effect (Heo et al, 2012;Min, Kim, Jeon, & Han, 2011). Among these pigment, fucoxanthin are found in brown algae and chrysophyta, have been reported to improve oxidative stress and metabolic syndrome such as anti-diabetes and anti-obesity (Kang et al, 2011;Kumar, Hosokawa, & Miyashita, 2013;Liu, Liang, & Hu, 2011;Maeda, Hosokawa, Sashima, Funayama, & Miyashita, 2005;Maeda, Hosokawa, Sashima, & Miyashita, 2007;Nishikawa, Hosokawa, & Miyashita, 2012;Woo et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Protective effect of fucoxanthin isolated from Ishige okamurae against high-glucose induced oxidative stress in human umbilical vein endothelial cells and zebrafish model

Kang

Lee

et al. 2014

Journal of Functional Foods

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Available online A B S T R A C THigh glucose induced oxidative stress is implicated in intracellular toxicity in tissue and blood vessel such as oxidative stress, lipid peroxidation, and cell death. In this study, we attempted to investigate protective effects of fucoxanthin isolated from Ishige okamurae against high glucose induced oxidative stress in human umbilical vein endothelial cells (HUVEC) and zebrafish model. The ROS generation, lipid peroxidation and cell death were significantly reduced in both the fucoxanthin treated HUVEC and zebrafish in vivo model, compared to those of both negative controls. This study indicates that fucoxanthin could protect cells and organ injury against oxidative stress induced by high glucose in vitro HUVEC and in vivo zebrafish model.

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Section: Introductionmentioning

confidence: 99%

Protective effect of fucoxanthin isolated from Ishige okamurae against high-glucose induced oxidative stress in human umbilical vein endothelial cells and zebrafish model

Kang

Lee

et al. 2014

Journal of Functional Foods

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“…1 filter paper, and evaporated under a vacuum using a rotary evaporator (BUCHI Co., Flawil, Switzerland). The extract was thoroughly dried for removal of solvents and stored in a deep freezer (−80°C) (22). 2.8 g of extract per 13.0 g of powdered S. ringgoldianum was obtained.…”

Section: Methodsmentioning

confidence: 99%

Hypoglycemic Effect of Sargassum ringgoldianum Extract in STZ-induced Diabetic Mice

Lee

Han

2012

JFN

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This study was designed to investigate whether Sargassum ringgoldianum extract may inhibit α-glucosidase and α-amylase activities, and alleviate postprandial hyperglycemia in streptozotocin-induced diabetic mice. The IC50 values of Sargassum ringgoldianum extract against α-glucosidase and α-amylase were 0.12 mg/mL and 0.18 mg/mL, respectively, which evidenced higher activities than those of acarbose. The blood glucose levels of the Sargassum ringgoldianum extract administered group were significantly lower compared to the control group in the streptozotocin-induced diabetic mice. Moreover, the area under the two-hour blood glucose response curve was significantly reduced and the absorption of dietary carbohydrates was delayed after administration of Sargassum ringgoldianum extract in the diabetic mice. Therefore, these results indicated that Sargassum ringgoldianum extract may help decrease the postprandial blood glucose level via inhibiting α-glucosidase.

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“…The antidiabetic effect of Ishige okamurae methanolic extract (IOE) on postprandial glucose load and insulin resistance in male C57BL/KsJ-db/db mice was studied (Min et al, 2011). The insulin resistance and fasting blood glucose levels were enhanced and HbA1c levels were lowered in IOE-treated group mice as compared with DMC (diabetic mellitus control) group mice.…”

Section: A-glucosidase and A-amylase Inhibitory Activitymentioning

confidence: 99%

“…Similarly, polyphenol-rich extract from brown alga Ishige okamurae significantly reduced hyperinsulinemia among diabetes mellitus type-2 mice by enhancing the glucokinase activity, whereas G6Pase and PEPCK activities were reduced. Also the hepatic glycogen level was elevated (Min et al, 2011). Only very few investigations have been done at the cellular level to study the functions of polyphenols isolated from marine algae.…”

Section: Polyphenols On Cellular and Molecular Metabolism Of Carbohydmentioning

confidence: 99%

New insights into seaweed polyphenols on glucose homeostasis

Murugan

Karim

Yusoff

et al. 2015

Pharmaceutical Biology

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Context: Polyphenol-rich marine macroalgae are gaining dietary importance due to their influence over diabetes mellitus and the role as a vital source of high-value nutraceuticals. Their assorted beneficial effects on human health include competitive inhibition of digestive enzymes, varying the activity of hepatic glucose-metabolizing enzymes, lowering the plasma glucose levels, and lipid peroxidation, delaying the aging process. Objective: In this paper, we review the health beneficial effects of polyphenols and phlorotannins from brown seaweeds with special emphasis on their inhibitory effects on carbohydrate-metabolizing enzymes. Methods: A survey of literature from databases such as Sciencedirect, Scopus, Pubmed, Springerlink, and Google Scholar from the year 1973 to 2013 was done to bring together the information relating to drug discovery from brown seaweeds as a source for diabetes treatment. Results: Over the past two decades, 20 different bioactive polyphenols/phlorotannins have been isolated and studied from 10 different brown algae. Discussion of the positive effect on the inhibition of enzymes metabolizing carbohydrates in both in vitro and in vivo experiments are included. Conclusion: Despite the recent advancements in isolating bioactive compounds from seaweeds with potential health benefit or pharmaceutical behavior, studies on the polyphenol effectiveness on glucose homeostasis in human beings are very few in response to their functional characterization. Added research in this area is required to confirm the close connection of polyphenol rich seaweed-based diet consumption with glucose homeostasis and the exciting possibility of prescribing polyphenols to treat the diabetes pandemic.

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Ishige okamurae ameliorates hyperglycemia and insulin resistance in C57BL/KsJ-db/db mice

Cited by 51 publications

References 30 publications

Protective effect of fucoxanthin isolated from Ishige okamurae against high-glucose induced oxidative stress in human umbilical vein endothelial cells and zebrafish model

Protective effect of fucoxanthin isolated from Ishige okamurae against high-glucose induced oxidative stress in human umbilical vein endothelial cells and zebrafish model

Hypoglycemic Effect of Sargassum ringgoldianum Extract in STZ-induced Diabetic Mice

New insights into seaweed polyphenols on glucose homeostasis

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