2016
DOI: 10.18632/aging.101028
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Abstract: Ischemic stroke is associated with aging. It is possible to predict chronological age by measuring age-related changes in DNA methylation from multiple CpG sites across the genome, known as biological age. The difference between biological age and actual chronological age would indicate an individual's level of aging. Our aim was to determine the biological age of ischemic stroke patients and compare their aging with controls of the same chronological age. A total of 123 individuals, 41 controls and 82 patient… Show more

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Cited by 48 publications
(61 citation statements)
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References 52 publications
(55 reference statements)
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“…A history of hypertension, diabetes and cardiovascular or cerebrovascular disease were included given the potential association with earlier death and dementia. Furthermore, such health outcomes increase with advancing age and so greater epigenetic age could be associated with susceptibility to these conditions [24,25]. An interaction term for sex and measure of accelerated ageing was included as sex is strongly linked to both AgeAccelPheno and AgeAccelGrim.…”
Section: Additional Variablesmentioning
confidence: 99%
“…A history of hypertension, diabetes and cardiovascular or cerebrovascular disease were included given the potential association with earlier death and dementia. Furthermore, such health outcomes increase with advancing age and so greater epigenetic age could be associated with susceptibility to these conditions [24,25]. An interaction term for sex and measure of accelerated ageing was included as sex is strongly linked to both AgeAccelPheno and AgeAccelGrim.…”
Section: Additional Variablesmentioning
confidence: 99%
“…In the field of stroke, it has been shown that the biological age (different from chronological age) of stroke patients measured by DNA methylation is different between cases suffering stroke and healthy controls. The stroke patients were biologically older than healthy controls [44] . The authors of this study calculated the “epigenetic age” or “biological age” using the DNAm levels of whole-blood DNA and using the Hannum method [44] , [45] .…”
Section: Dna Methylation In Strokementioning
confidence: 89%
“…The stroke patients were biologically older than healthy controls [44] . The authors of this study calculated the “epigenetic age” or “biological age” using the DNAm levels of whole-blood DNA and using the Hannum method [44] , [45] . This method is based on the methylation levels from 71 methylation probes from a 450 K EWAS Methylation array.…”
Section: Dna Methylation In Strokementioning
confidence: 89%
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“…These changes can be employed for epigenetic age prediction [11][12][13]. Increased epigenetic age was observed to be associated with higher all-cause mortality [14][15][16][17], less favorable cancer outcome [18], ischemic stroke [19], and trisomy 21 / Down syndrome (DS) [20,21].…”
mentioning
confidence: 99%