Ischemia May Be the Primary Cause of the Neurologic Deficits in Classic Migraine

Interictal Dysfunction of a Brainstem Descending Modulatory Center in Migraine Patients

“…The dysfunction we observed may be a result of damage secondary to a history of repeated migraine attacks [30]–[32]. However, the mechanism of such damage is not known although a neurovascular etiology has been suggested.…”

Interictal Dysfunction of a Brainstem Descending Modulatory Center in Migraine Patients

“…The dysfunction we observed may be a result of damage secondary to a history of repeated migraine attacks [30]–[32]. However, the mechanism of such damage is not known although a neurovascular etiology has been suggested.…”

Assessment of MRI abnormalities of the brainstem from patients with migraine and multiple sclerosis

“…Although this study cannot provide definitive answers about the pathologic nature of the observed brainstem changes in patients with migraine (but definitive histopathologic correlations in these patients are unlikely to be ever obtained), the most plausible explanation for these changes is that they might result from ischemia caused by repeated blood flow reductions, which can persist for hours during migraine attacks [2,5].…”

Neuroexcitatory Amino Acid Levels in Plasma and Cerebrospinal Fluid During Migraine Attacks

“…Pertinent to current hypothesis of the pathophysiology of migraine, hypoxic and ischemic states produce increased release of glutamate into the extracellular space (28). Low cortical blood flow has been demonstrated in migraine during an attack (6, 7), even to ischemic levels (29), though other reports fail to demonstrate an ischemic effect (30). We still do not know if changes of cerebral blood flow in migraine are primary or secondary.…”

Interictal Dysfunction of a Brainstem Descending Modulatory Center in Migraine Patients

“…The dysfunction we observed may be a result of damage secondary to a history of repeated migraine attacks [30]–[32]. However, the mechanism of such damage is not known although a neurovascular etiology has been suggested.…”

Assessment of MRI abnormalities of the brainstem from patients with migraine and multiple sclerosis

“…Although this study cannot provide definitive answers about the pathologic nature of the observed brainstem changes in patients with migraine (but definitive histopathologic correlations in these patients are unlikely to be ever obtained), the most plausible explanation for these changes is that they might result from ischemia caused by repeated blood flow reductions, which can persist for hours during migraine attacks [2,5].…”

Neuroexcitatory Amino Acid Levels in Plasma and Cerebrospinal Fluid During Migraine Attacks

“…Pertinent to current hypothesis of the pathophysiology of migraine, hypoxic and ischemic states produce increased release of glutamate into the extracellular space (28). Low cortical blood flow has been demonstrated in migraine during an attack (6, 7), even to ischemic levels (29), though other reports fail to demonstrate an ischemic effect (30). We still do not know if changes of cerebral blood flow in migraine are primary or secondary.…”

Interictal Dysfunction of a Brainstem Descending Modulatory Center in Migraine Patients

“…The dysfunction we observed may be a result of damage secondary to a history of repeated migraine attacks [30]–[32]. However, the mechanism of such damage is not known although a neurovascular etiology has been suggested.…”

Assessment of MRI abnormalities of the brainstem from patients with migraine and multiple sclerosis

“…Although this study cannot provide definitive answers about the pathologic nature of the observed brainstem changes in patients with migraine (but definitive histopathologic correlations in these patients are unlikely to be ever obtained), the most plausible explanation for these changes is that they might result from ischemia caused by repeated blood flow reductions, which can persist for hours during migraine attacks [2,5].…”

Neuroexcitatory Amino Acid Levels in Plasma and Cerebrospinal Fluid During Migraine Attacks

“…Pertinent to current hypothesis of the pathophysiology of migraine, hypoxic and ischemic states produce increased release of glutamate into the extracellular space (28). Low cortical blood flow has been demonstrated in migraine during an attack (6, 7), even to ischemic levels (29), though other reports fail to demonstrate an ischemic effect (30). We still do not know if changes of cerebral blood flow in migraine are primary or secondary.…”