Is Zinc an Important Trace Element on Bone-Related Diseases and Complications? A Meta-analysis and Systematic Review from Serum Level, Dietary Intake, and Supplementation Aspects

Ceylan, Merve Nur; Akdas, Sevginur; Yazıhan, Nuray

doi:10.1007/s12011-020-02193-w

Cited by 41 publications

(33 citation statements)

References 61 publications

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“…Moreover, studies have shown that zinc supplementation can mitigate the risk of osteoporosis and improve the markers associated with bone formation such as alkaline phosphatase and osteocalcin, recovering mobility, especially in the elderly population [56].…”

Section: Discussionmentioning

confidence: 99%

A Novel Nutraceutical Formulation Can Improve Motor Activity and Decrease the Stress Level in a Murine Model of Middle-Age Animals

Tsoukalas

Zlatian

Mitroi

et al. 2021

JCM

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Ageing is a genetically programmed physiological process that is modulated by numerous environmental factors, associated with decreasing physiological function, decreasing reproductive rate and increasing age-related mortality rate. Maintaining mobility performance and physical function in the elderly is the main objective of the successful ageing concept. In this study, we aimed to evaluate the beneficial effect of a novel nutraceutical formulation containing Centella asiatica L. extract, vitamin C, zinc and vitamin D3 (as cholecalciferol) on motor activity and anxiety with the use of a murine model of old animals, as a means of providing proof for clinical use in the elderly, for enhancing physical strength and improving life quality. Eighteen Sprague Dawley 18 months old male rats were divided into three groups and received corn oil (the control group) or 1 capsule/kg bw Reverse supplement (treatment group 1) or 2 capsules/kg bw Reverse supplement (treatment group 2), for a period of 3 months. The Reverse supplement (Natural Doctor S.A, Athens, Greece) contains 9 mg Centella asiatica L. extract, vitamin C (200 mg as magnesium ascorbate), zinc (5 mg as zinc citrate), vitamin D3 (50 µg as cholecalciferol) per capsule. Before and after the treatment, the motor function and behavioral changes for anxiety and depression were evaluated using the open-field test, elevated plus-maze test and rotarod test. The supplementation with Reverse (Natural Doctor S.A) supplement can improve the locomotor activity in old rats in a dose-dependent manner, as demonstrated by an increase in the latency to leave from the middle square, in the number of rearings in the open field test, in the time spent in the open arms and time spent in the center in the elevated plus-maze test and the latency to all in all three consecutive trials in the rotarod test. Stress also decreased significantly in a dose-dependent manner, following the treatment with Reverse supplement, as was demonstrated by the decrease in the number of groomings at the open field test and time spent in the dark and the number of groomings at the elevated plus-maze test.

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Section: Discussionmentioning

confidence: 99%

A Novel Nutraceutical Formulation Can Improve Motor Activity and Decrease the Stress Level in a Murine Model of Middle-Age Animals

Tsoukalas

Zlatian

Mitroi

et al. 2021

JCM

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“…In the case of the OI–TiZn system, the potential osseointegration bonding can be implemented by the dissolution of the infiltrated biodegradable Zn–2%Fe alloy and, in parallel, the formation of bone tissue within the open space of the permanent Ti-base lattice implant. Other inherent advantages of OI–TiZn systems relate to the capability of Zinc to stimulate bone growth [ 29 ] and to act as an antibacterial substance that can prevent infections post-implantation.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, Zinc exhibited none of these disadvantageous characteristics [ 23 , 24 , 25 , 26 , 27 , 28 ]. In fact, Zn tends to stimulate bone growth [ 29 ] and act as an antibacterial material that is significantly effective in fighting infections [ 30 , 31 , 32 ]. However, research carried out by Guillory et al [ 33 ] indicated that pure Zn may suffer from insufficient corrosion degradation rates in in vivo conditions that consequently can provoke fibrous encapsulation and limit the proper dissolution of the implant.…”

Section: Introductionmentioning

confidence: 99%

Evaluating the Prospects of Ti-Base Lattice Infiltrated with Biodegradable Zn–2%Fe Alloy as a Structural Material for Osseointegrated Implants—In Vitro Study

et al. 2021

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The term “osseointegrated implants” mainly relates to structural systems that contain open spaces, which enable osteoblasts and connecting tissue to migrate during natural bone growth. Consequently, the coherency and bonding strength between the implant and natural bone can be significantly increased, for example in operations related to dental and orthopedic applications. The present study aims to evaluate the prospects of a Ti–6Al–4V lattice, produced by selective laser melting (SLM) and infiltrated with biodegradable Zn2%Fe alloy, as an OI–TiZn system implant in in vitro conditions. This combined material structure is designated by this study as an osseointegrated implant (OI–TiZn) system. The microstructure of the tested alloys was examined both optically and using scanning electron microscopy (SEM) and X-ray diffraction (XRD) analysis. The mechanical properties were assessed in terms of compression strength, as is commonly acceptable in cases of lattice-based structures. The corrosion performance was evaluated by immersion tests and electrochemical analysis in terms of potentiodynamic polarization and electrochemical impedance spectroscopy (EIS), all in simulated physiological environments in the form of phosphate buffered saline (PBS) solution. The cytotoxicity was evaluated in terms of indirect cell viability. The results obtained demonstrate the adequate performance of the OI–TiZn system as a non-cytotoxic structural material that can maintain its mechanical integrity under compression, while presenting acceptable corrosion rate degradation.

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“…Earlier studies on the relationship between serum Cu and BMD measured at various sites have yielded conflicting results as the associations were positive [28,29], negative [10,30], or neutral [31][32][33]. In turn, the association between serum Zn and BMD was positive in several reports [34][35][36]; however, in the recent meta-analysis, serum zinc level did not show a significant difference in overall bone turnover-related conditions, such as osteoporosis, osteopenia, fracture, or postmenopause from control groups, and it was not correlated with lumbar spine and hip BMD [37].…”

Section: Discussionmentioning

confidence: 97%

Bone Health in Aging Men: Does Zinc and Cuprum Level Matter?

et al. 2021

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The aim of this study was to assess the associations of serum and bone zinc (Zn) and cuprum (Cu) with bone mineral density (BMD) and content (BMC), markers of bone turnover, and sex hormones. The study group comprised 144 men treated with total hip replacement due to hip osteoarthritis. We measured total, free, and bioavailable testosterone, estradiol, and sex-hormone-binding globulin (sex hormones), as well as parathyroid hormone, osteocalcin, carboxy terminal collagen crosslinks, and N-terminal propeptide of type I procollagen (markers of bone turnover). Total body BMD, BMC, total and visceral fat, and appendicular skeletal mass (ASM) were measured using dual-energy X-ray absorptiometry. ASM index, and total and visceral fat were positively correlated with BMD. Bone Zn correlated neither with sex hormones nor with bone turnover markers; however, it was positively associated both with BMD and with BMC, while bone Cu (as opposed to serum Cu) was not. In multiple regression, the ASM index, Zn/Cu ratio (in both the serum and the bone), and serum Cu concentration were significantly associated with BMD and BMC after adjustment for age and body mass index (BMI). Our results suggest that the Zn/Cu ratio in both the serum and the bone may exert a significant positive effect on total BMD and BMC.

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Is Zinc an Important Trace Element on Bone-Related Diseases and Complications? A Meta-analysis and Systematic Review from Serum Level, Dietary Intake, and Supplementation Aspects

Cited by 41 publications

References 61 publications

A Novel Nutraceutical Formulation Can Improve Motor Activity and Decrease the Stress Level in a Murine Model of Middle-Age Animals

A Novel Nutraceutical Formulation Can Improve Motor Activity and Decrease the Stress Level in a Murine Model of Middle-Age Animals

Evaluating the Prospects of Ti-Base Lattice Infiltrated with Biodegradable Zn–2%Fe Alloy as a Structural Material for Osseointegrated Implants—In Vitro Study

Bone Health in Aging Men: Does Zinc and Cuprum Level Matter?

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