Is tryptophan metabolism involved in sleep apnea-related cardiovascular co-morbidities and cancer progression?

Boulet, Lysiane; Flore, Patrice; Gouellec, Audrey Le; Toussaint, Bertrand; Pépin, Jean‐Louis; Faure, Patrice

doi:10.1016/j.mehy.2015.06.022

Cited by 12 publications

(11 citation statements)

References 118 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…5), are also related to risk of diseases. Indolelactate, a metabolite of tryptophan72, reportedly plays an important role in the progression of cancers and CVD73. The level of trans -4-hydroxyproline in cancer patients was significantly higher than those in healthy subjects74.…”

Section: Discussionmentioning

confidence: 99%

Urinary Biomarkers of Whole Grain Wheat Intake Identified by Non-targeted and Targeted Metabolomics Approaches

Zhu

Wang

et al. 2016

Sci Rep

View full text Add to dashboard Cite

Mounting evidence suggests that whole grain (WG) intake plays an important role in chronic disease prevention. However, numerous human studies have failed to produce clear-cut conclusions on this topic. Here, a combination of non-targeted and targeted metabolomics approaches, together with kinetic studies, was used to investigate biomarkers of WG wheat intake and further explore the diet-disease associations. Via these integrated approaches, forty-one compounds were identified as the most discriminating endogenous metabolites after WG versus refined grain (RG) wheat bread consumption. The corresponding biological assessment of these endogenous changes suggests that, in contrast to RG consumption, WG wheat consumption may facilitate antioxidant defense systems and moderate the risk factors of cancer, cardiovascular diseases, and other chronic diseases. A panel of urinary markers consisting of seven alkylresorcinol metabolites and five benzoxazinoid derivatives as specific biomarkers, as well as five phenolic acid derivatives, was also established to cover multiple time points and longer time periods for correctly and objectively monitoring WG wheat intake. Through these findings, we have established a comprehensive biomarker pool to better assess WG wheat consumption, and to monitor the endogenous changes that are linked to health effects of WG wheat consumption.

show abstract

Section: Discussionmentioning

confidence: 99%

Urinary Biomarkers of Whole Grain Wheat Intake Identified by Non-targeted and Targeted Metabolomics Approaches

Zhu

Wang

et al. 2016

Sci Rep

View full text Add to dashboard Cite

show abstract

“…61 More speculatively, others have reported on L-tryptophan as a potential agent for improving sleep. 62,63 Finally, several investigators have attempted to delineate drug discovery strategies or identify therapeutic targets for future medical treatments of OSA. 64–66…”

Section: Treatment Options For Obstructive Sleep Apnoeamentioning

confidence: 99%

Narrative review of contemporary treatment options in the care of patients with obstructive sleep apnoea

Ferguson

Magill

Kotecha

2017

Ther Adv Respir Dis

View full text Add to dashboard Cite

Snoring and obstructive sleep apnoea (OSA) are increasingly common conditions, and confer a significant health and socioeconomic burden. Furthermore, untreated OSA represents a significant mortality risk. Patients require careful assessment, including detailed clinical history and examination, sleep study and drug-induced sleep endoscopy (DISE). Although nasal continuous positive airway pressure (nCPAP) is the gold standard treatment for moderate and severe OSA, multidisciplinary team assessment is often required to develop the best treatment plan for an individual, especially when nasal CPAP is poorly tolerated. There is a wide range of medical and surgical treatment options, and following appropriate patient selection and assessment, a focused site-specific, often multilevel, intervention is indicated. There is an increasing body of evidence in the literature supporting these multilevel interventions and with agreement on standardized outcome measures more trials are likely to improve the robustness of these data further.

show abstract

“…En effet, de nombreux auteurs ont impliqué cette voie dans la pathologie cardiovasculaire, que ce soit en tant que facteur de risque (8), modulateur du stress oxydant (9) ou en tant que prédisposition génétique à l'hypertension artérielle (10). Différentes données nous ont permis de formuler l'hypothèse que cette voie métabolique pourrait être un des facteurs de comorbidité cardiovasculaire présente dans le syndrome d'apnée du sommeil (11) (24), la voie des kynurénines est maintenant également impliquée dans cette pathologie (25), ainsi que dans plusieurs pathologies neurodégénératives, telle que la maladie d'Alzheimer (26). Cette voie est depuis peu également décrite comme modifiée dans la schizophrénie, où une diminution cérébrale de AK associée à une augmentation de QA sont présentes (27), tandis qu'une accumulation de QA seule a été retrouvée dans l'autisme (28).…”

Section: Voie Des Kynuréninesunclassified

Mise au point du dosage sanguin des métabolites de la voie du tryptophane en HPLC-MS/MS et perspectives dans le suivi biologique des patients atteints de phénylcétonurie

Boulet

Montérémal

Meunier

et al. 2016

Archives de Pédiatrie

Self Cite

View full text Add to dashboard Cite

show abstract

Is tryptophan metabolism involved in sleep apnea-related cardiovascular co-morbidities and cancer progression?

Cited by 12 publications

References 118 publications

Urinary Biomarkers of Whole Grain Wheat Intake Identified by Non-targeted and Targeted Metabolomics Approaches

Urinary Biomarkers of Whole Grain Wheat Intake Identified by Non-targeted and Targeted Metabolomics Approaches

Narrative review of contemporary treatment options in the care of patients with obstructive sleep apnoea

Mise au point du dosage sanguin des métabolites de la voie du tryptophane en HPLC-MS/MS et perspectives dans le suivi biologique des patients atteints de phénylcétonurie

Contact Info

Product

Resources

About