Is TIMP‐1 a biomarker for periodontal disease? A systematic review and meta‐analysis

Brouwer, Puk de; Bikker, Floris J.; Brand, H.S.; Kaman, Wendy E.

doi:10.1111/jre.12957

Cited by 14 publications

(10 citation statements)

References 38 publications

(72 reference statements)

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“…TIMP-1 has a more restricted inhibitory range than the other TIMPs, also strongly binds to both active and zymogen of MMP-9 than to MMP-8. An imbalance between the MMP-8, MMP-9, and TIMP-1 subsequently drives the various pathologic disorders (Bostanci et al, 2021;Vandenbroucke & Libert, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, HNE can proteolytically inactivate TIMP-1 (Jackson et al, 2010). An imbalance between MMP-8 and TIMP-1 can lead to tissue destruction and functional alterations, thereby leading to destructive inflammatory diseases (Bostanci et al, 2021;Lahdentausta et al, 2018). Enzymes among MPO and HNE can also potentiate the destructive MMP cascade (Nizam et al, 2014).…”

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confidence: 99%

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Salivary and serum levels of neutrophil proteases in periodontitis and rheumatoid arthritis

et al. 2023

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ObjectiveThe aim was to profile serum and salivary levels of active‐matrix metalloproteinase (aMMP)‐8, tissue inhibitor MMP (TIMP)‐1, aMMP‐8/TIMP‐1 ratio, total MMP (tMMP)‐9, tMMP‐9/TIMP‐1 ratio, myeloperoxidase (MPO), and human neutrophil elastase (HNE) in periodontitis and rheumatoid arthritis (RA).Materials and MethodsRheumatoid arthritis patients with periodontitis (RA + P, n = 26), periodontally healthy RA patients (RA, n = 23), systemically healthy periodontitis patients (P, n = 24), and controls (C, n = 24) were included. aMMP‐8 levels were determined by a time‐resolved immunofluorescence assay (IFMA), TIMP‐1, tMMP‐9, MPO, and HNE levels were measured by enzyme‐linked immunosorbent (ELISA) assays.ResultsHigher salivary aMMP‐8 (p < 0.001), aMMP‐8/TIMP‐1 ratio (p = 0.043), tMMP‐9 (p = 0.011), tMMP‐9/TIMP‐1 ratio (p = 0.022), MPO (p = 0.026) and HNE (p < 0.001) levels were detected in P relative to the controls. Salivary TIMP‐1 was increased in RA patients regardless of periodontal status (RA + P vs. P: p = 0.038; RA vs. C: p = 0.020). Serum neutrophil proteases were increased in RA groups (RA + P, RA) compared to systemically healthy groups (P, C) (p < 0.05).ConclusionsSerum levels of neutrophil proteases were increased in RA study groups; however rheumatologic status seemingly does not affect salivary levels of these proteins.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Salivary and serum levels of neutrophil proteases in periodontitis and rheumatoid arthritis

et al. 2023

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“…Отриманий результат доцільно співвіднести з даними проведеного метааналізу [9], в якому зазначалась суперечливість діагностичної значущості ТІМР-1 у ротовій рідині у хворих на пародонтит.…”

Section: співвідношення ммп та тімр-1 у ротовій рідині в дослідних рі...unclassified

“…The imbalance of MMP and TIMP-1 in the early stages of the pathological process indicates the greatest expediency of using MMP inhibitors in the treatment of patients with gingivitis and periodontitis of the initial degree. У свою чергу, активність ММП регулюється специфічними тканинними інгібіторами ТІМР (Tissue Inhibitor of Metalloproteinase), а дисбаланс між ними зв'язують із перебігом остеорезорбтивних процесів у тканинах пародонта [9]. Установлено специфічність дії ТІМР-1 до ММП-8 та 129 22/ Том XXVII / 3 ММП-9 у хворих на пародонтит, проте цей інгібітор здатний пригнічувати й решту ММП [7].…”

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Matrix metalloproteinases in the oral fluid as a characteristic of inflammatory-destructive process in periodontal tissues

A.V.¹,

S.O.²

2022

Med. perspekt.

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The study of the imbalance between the activity of matrix metalloproteinases and their regulation markers in the oral fluid of patients with generalized periodontitis is necessary for creation of effective methods for early diagnosis and preventive treatment of the disease. The aim of the research was to examine the oral fluid of persons with healthy periodontal tissues, patients with chronic diffuse gingivitis and generalized periodontitis for concentrations of matrix metalloproteinases and their inhibitor, anti- and pro-inflammatory cytokines, markers of bone metabolism and to compare obtained results. 90 persons aged 32-45 years were examined, including 30 persons with intact periodontal tissues, 30 patients with chronic diffuse catarrhal gingivitis and generalized periodontitis of the initial degree and 30 ones with chronic generalized periodontitis of I-II degrees. Periodontal status was assessed using clinical indices and bone mineral density according to computed tomography data. The method of enzyme-linked immunosorbent assay (ELISA) was used to determine the concentration of matrix metalloproteinases MMP-2, MMP-3, MMP-8, MMP-9, MMP-13, tissue inhibitor of metalloproteinases TIMP-1, interleukins-1β, -6 and -4, bone metabolism markers – tartrate-resistant acidic phosphatase and bone alkaline phosphatase, osteocalcin in the oral fluid. The initiation of the inflammatory-destructive process in the periodontal tissues was characterized by an increase levels of MMP and pro-inflammatory IL-1β and IL-6 (р<0.05), a decrease in the concentration of TIMP-1 (р>0.05) and anti-inflammatory IL-4 (р<0.05), against the background of the absence of dynamics of bone metabolism markers in the oral fluid. The progression of the process at the І-II degrees of periodontitis was accompanied by a further increase in the concentration of pro-inflammatory interleukins, an increase in the activity of tartrate-resistant acid phosphatase and a decrease in bone alkaline phosphatase and osteocalcin (р<0.05) in the oral fluid, while the content of MMP did not change (р>0.05). The expression of MMP is important for the preventive diagnosis of generalized periodontitis, but it is not indicative for determining the severity of the disease. The imbalance of MMP and TIMP-1 in the early stages of the pathological process indicates the greatest expediency of using MMP inhibitors in the treatment of patients with gingivitis and periodontitis of the initial degree.

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“…6 TIMP-1 is known as an inhibitor of matrix metalloproterinase. 7 Saliva contains biomarkers specific to periodontitis and thus qualitative changes in the composition of these biomarkers can be diagnosed. Experimental evidence suggests that the most important pathway involving MMP as active collagenase and gelatinase is found not only in gingival sulcus fluid but also in saliva and biopsy specimens in inflammatory periodontal tissue.…”

Section: Introductionmentioning

confidence: 99%

Comparison of matrix metalloproteinase-13 and tissue inhibitor of metalloproteinase-1 levels and alveolar bone density in chronic periodontitis before and after scaling and root planning

Nasution

Nainggolan²,

Meydhyono³

2022

Majalah Kedokteran Gigi Indonesia

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Periodontitis is typically associated with disorders characterized by compromised tooth-supporting tissue. Damage to periodontal tissue is caused by an imbalance between matrix metalloproteinases and their inhibitors. Decreased tissue inhibitor and elevated matrix metalloproteinase levels result in collagen connective tissue and bone degradation. Several studies have shown that high levels of matrix metalloproteinase-13 (MMP-13) and low levels of tissue inhibitor of metalloproteinase-1 (TIMP-1) are also found in gingival crevicular fluid and saliva of patients with periodontitis. The purpose of this study was to determine the comparison of MMP-13 levels, TIMP-1 levels of saliva and bone density in patients with chronic periodontitis before and after scaling and root planning (SRP). The study samples were selected from patients who came for treatment at the Periodontics Installation of Universitas Sumatera Utara. A total of 16 patients were selected (n = 16) with a diagnosis of chronic periodontitis. The result showed that salivary MMP-13 levels in chronic periodontitis patients before SRP were higher than salivary MMP-13 levels after SRP and the difference was statistically significant (p < 0.05). It was also revealed that salivary TIMP-1 levels and alveolar bone density in chronic periodontitis patients before SRP were lower than that after SRP and the difference was statisticallysignificant (p < 0.05). There was a positive correlation between clinical parameters and salivary MMP-13 levels in patients with chronic periodontitis before and after SRP, but it was not statistically significant (p > 0.05). There was a negative correlation between clinical parameters and salivary TIMP-1 levels in patients with chronic periodontitis before and after SRP, but it was not statistically significant (p > 0.05).

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Is TIMP‐1 a biomarker for periodontal disease? A systematic review and meta‐analysis

Cited by 14 publications

References 38 publications

Salivary and serum levels of neutrophil proteases in periodontitis and rheumatoid arthritis

Salivary and serum levels of neutrophil proteases in periodontitis and rheumatoid arthritis

Matrix metalloproteinases in the oral fluid as a characteristic of inflammatory-destructive process in periodontal tissues

Comparison of matrix metalloproteinase-13 and tissue inhibitor of metalloproteinase-1 levels and alveolar bone density in chronic periodontitis before and after scaling and root planning

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