Is there any effect of insulin resistance on male reproductive system?

Verit, Ayhan; Verit, Fatma Ferda; Öncel, Halil Ferat; Çiftçi, Halil

doi:10.4081/aiua.2014.1.5

Cited by 12 publications

(9 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the meantime, IR is directly associated with 1GF-1 levels (Friedrich et al, 2012;Sesti et al, 2005). However, an inverse correlation between IR and male reproductive functions could not be found (Verit et al, 2014). It has been demonstrated that parents and brothers (Sir-Petermann et al, 2002;Yildiz et al, 2003) and sons (Recabarren et al, 2008b) of PCOS women exhibit IR.…”

Section: Discussionmentioning

confidence: 94%

Increased insulin resistance in men with unexplained infertility

Mansour

El-Faissal

Kamel

et al. 2017

Reproductive BioMedicine Online

View full text Add to dashboard Cite

This prospective case-control study aimed to test the presence of insulin resistance (IR) in men with unexplained infertility. We included two groups: the study group including 160 infertile men with unexplained oligozoospermia (sperm count <10 × 10/ml) and normal hormonal profile, and the control group of 79 men with proven fertility within the preceding year. A fasting blood test measured IR, FSH, LH, total cholesterol, low-density lipoprotein, high-density lipoprotein and triglycerides. Insulin level was significantly higher in the study group (13.67 ± 10.44) compared with the control group (5.46 ± 3.15), P < 0.0001, and IR was significantly higher in the study group, P < 0.0001. FSH was significantly (P < 0.0001) higher in the study group (4.71 ± 2.57) than the control group (3.15 ± 1.92). LH was significantly higher in the study group (4.98 ± 2.41) compared with the control group (3.15 ± 1.12), P < 0.0001. Total cholesterol was significantly higher in the study group (198.29 ± 37.52) than the control group (182.45 ± 35.92), P < 0.05. In conclusion, IR in men with unexplained infertility may be a cause of reproductive and metabolic abnormalities. The benefit of insulin-sensitizing agents for these patients should be tested.

show abstract

Section: Discussionmentioning

confidence: 94%

Increased insulin resistance in men with unexplained infertility

Mansour

El-Faissal

Kamel

et al. 2017

Reproductive BioMedicine Online

View full text Add to dashboard Cite

show abstract

“…In a follow-up study, the authors reported that the low testosterone levels observed were not only associated with insulin sensitivity but also with markers of mitochondrial function (Pitteloud et al 2005b). Nonetheless, a recent study observed no relation between insulin resistance and male reproductive function (Verit et al 2014). These contradictory results might be related to the different patients' selection criteria and number.…”

Section: Testicular Levelmentioning

confidence: 96%

Antidiabetic therapies and male reproductive function: where do we stand?

Tavares¹,

Escada-Rebelo²,

Silva³

et al. 2018

Reproduction

View full text Add to dashboard Cite

Diabetes mellitus has been increasing at alarming rates in recent years, thus jeopardizing human health worldwide. Several antidiabetic drugs have been introduced in the market to manage glycemic levels, and proven effective in avoiding, minimizing or preventing the appearance or development of diabetes mellitus-related complications. However, and despite the established association between such pathology and male reproductive dysfunction, the influence of these therapeutic interventions on such topics have been scarcely explored. Importantly, this pathology may contribute toward the global decline in male fertility, giving the increasing preponderance of diabetes mellitus in young men at their reproductive age. Therefore, it is mandatory that the reproductive health of diabetic individuals is maintained during the antidiabetic treatment. With this in mind, we have gathered the available information and made a critical analysis regarding the effects of several antidiabetic drugs on male reproductive function. Unlike insulin, which has a clear and fundamental role on male reproductive function, the other antidiabetic therapies' effects at this level seem incoherent. In fact, studies are highly controversial possibly due to the different experimental study approaches, which, in our opinion, suggests caution when it comes to prescribing such drugs to young diabetic patients. Overall, much is still to be determined and further studies are needed to clarify the safety of these antidiabetic strategies on male reproductive system. Aspects such as the effects of insulin levels variations, consequent of insulin therapy, as well as what will be the impact of the side effect hypoglycemia, common to several therapeutic strategies discussed, on the male reproductive system are still to be addressed.Reproduction (2018) 155 R13-R37

show abstract

“…HOMA-IR is negatively correlated with serum T and progesterone (PR) (p<0.05). However, Verit and colleagues (38) observed that HOMA-IR shows no significant correlation with sperm count, motility, and morphology. Zag (zinc alpha glycoprotein) ( 39) is a new type of adipokines, which plays an important role in alleviating IR.…”

Section: Effect Of Insulin Resistance On Male Reproductionmentioning

confidence: 97%

Diabetes Mellitus Causes Male Reproductive Dysfunction: A Review of the Evidence and Mechanisms

Zu-bin

Yin

et al. 2021

In Vivo

View full text Add to dashboard Cite

The metabolic disorders caused by diabetes can lead to various complications, including dysfunction of the male reproductive system. In patients with diabetes, longterm hyperglycemia results in diabetic vascular neuropathy, oxidative stress injury, abnormal zinc metabolism, and insulin resistance syndrome. In addition, insulin deficiency and resistance in diabetes can damage the hypothalamus, pituitary gland, gonads, and perigonads. This can reduce the secretion of sex hormones including gonadotropin-releasing hormone, follicle stimulating hormone, luteinizing hormone, and testosterone, and can lead to testicular atrophy, stromal cell atrophy, seminiferous tubule damage, spermatogenic cell damage, and other structural injuries of the male reproductive organs. These actions can affect male fertility and reproductive health. Herein, we review studies that report a causative role of diabetes in male reproductive function. We also discuss the evidence-based mechanisms involved in the processes of diabetes-related male sexual and reproductive dysfunction as well as the progress in treatment.

show abstract

Is there any effect of insulin resistance on male reproductive system?

Cited by 12 publications

References 24 publications

Increased insulin resistance in men with unexplained infertility

Increased insulin resistance in men with unexplained infertility

Antidiabetic therapies and male reproductive function: where do we stand?

Diabetes Mellitus Causes Male Reproductive Dysfunction: A Review of the Evidence and Mechanisms

Contact Info

Product

Resources

About