Is there an association between maternal anxiety propensity and pregnancy outcomes?

Ravid, Eyal; Salzer, Liat; Arnon, Liat; Eisner, Michal; Wiznitzer, Arnon; Weller, Aron; Koren, Lee; Hadar, Eran

doi:10.1186/s12884-018-1925-8

Cited by 21 publications

(17 citation statements)

References 45 publications

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“…When restricted to studies investigating depression (Avalos, Chen, & Li, 2015; Bandoli & Chambers, 2017; Cripe, Frederick, Qiu, & Williams, 2011; Dayan et al, 2006; De Vera & Bérard, 2012; Goedhart et al, 2010; Henrichs et al, 2010; Hermon, Wainstock, Sheiner, Golan, & Walfisch, 2019; Heun-Johnson et al, 2019; Ibanez et al, 2012; Katon, Russo, Melville, Katon, & Gavin, 2012; Khanghah, Khalesi, & Rad, 2020; Kim et al, 2013; Kurki, Hiilesmaa, Raitasalo, Mattila, & Ylikorkala, 2000; Lutsiv et al, 2015; Mogos et al, 2019; Navaratne, Foo, & Kumar, 2016; Packer, Pilliod, Chatroux, Caughey, & Valent, 2019; Palmsten, Setoguchi, Margulis, Patrick, & Hernández-Díaz, 2012; Qiu, Sanchez, Lam, Garcia, & Williams, 2007; Ruiz et al, 2012; Schmidt et al, 2019; Suri et al, 2007; Venkatesh, Ferguson, Smith, Cantonwine, & McElrath, 2019; Yedid Sion, Harlev, Weintraub, Sergienko, & Sheiner, 2016; Yonkers, Gilstad-Hayden, Forray, & Lipkind, 2017), results indicated an increased risk of HDP (RR = 1.30; 95% CI 1.19–1.43; 26 studies). Analysis of studies on anxiety (Avraham, Tamar, Eyal, & Gali, 2020; Bánhidy, Ács, Puhó, & Czeizel, 2006; Catov, Abatemarco, Markovic, & Roberts, 2010; Chen, Lin, & Lee, 2010; De Vera & Bérard, 2012; Garza-Veloz et al, 2017; Ibanez et al, 2012; Kordi, Vahed, Rezaee, Reza, & Lotfalizadeh, 2017; Pavlov, Steiner, Kessous, Weintraub, & Sheiner, 2014; Ravid et al, 2018) also indicated an increased risk of HDP (RR = 1.49; 95% CI 1.13–21.98; 10 studies).…”

Section: Resultsmentioning

confidence: 99%

Depressed mood and anxiety as risk factors for hypertensive disorders of pregnancy: a systematic review and meta-analysis

et al. 2020

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Background Psychosocial factors have been implicated as both a cause and consequence of hypertension in the general population but are less understood in relation to hypertensive disorders of pregnancy (HDP). The aims of this review were to (1) synthesize the existing literature examining associations between depression and/or anxiety in pregnancy and HDP and (2) assess if depression and/or anxiety in early pregnancy was a risk factor for HDP. Methods A comprehensive search of Medline, Embase, CINAHL, and PsycINFO was conducted from inception to March 2020 using terms related to ‘pregnancy’, ‘anxiety’, ‘depression’, and ‘hypertensive disorders’. English-language cohort and case-control studies were included if they reported: (a) the presence or absence of clinically significant symptoms of depression/anxiety, or a medical record diagnosis of depression or an anxiety disorder in pregnancy; (b) diagnosis of HDP; and/or (c) data comparing the depressed/anxious group to the non-depressed/anxious group on HDP. Data related to depression/anxiety, HDP, study characteristics, and aspects related to study quality were extracted independently by two reviewers. Random-effects meta-analyses of estimated pooled relative risks (RRs) were conducted for depression/anxiety in pregnancy and HDP. Results In total, 6291 citations were retrieved, and 44 studies were included across 61.2 million pregnancies. Depression and/or anxiety were associated with HDP [RR = 1.39; 95% confidence interval (CI) 1.25–1.54]. Conclusions When measurement of anxiety or depression preceded diagnosis of hypertension, the association remained (RR = 1.27; 95% CI 1.07–1.50). Women experiencing depression or anxiety in pregnancy have an increased prevalence of HDP compared to their non-depressed or non-anxious counterparts.

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Section: Resultsmentioning

confidence: 99%

Depressed mood and anxiety as risk factors for hypertensive disorders of pregnancy: a systematic review and meta-analysis

et al. 2020

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“…Depression during pregnancy can also have adverse effects on the fetus, the most important of which are preterm labor and low birth weight [9]. Anxiety during pregnancy also increases the risk of preterm labor [10], low birth weight [11], preeclampsia and cesarean delivery [12].…”

Section: Introductionmentioning

confidence: 99%

Depression, stress, anxiety and their predictors in Iranian pregnant women during the outbreak of COVID-19

et al. 2020

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Background Pregnancy as a sensitive period of a woman’s life can be affected by various psychological factors that can have adverse effects on the woman, her fetus and future baby. Since COVID-19 is a new phenomenon with limited information available, it may have adverse psychological effects on pregnant women. Therefore, this study was conducted to determine the status of depression, stress, anxiety and their predictors in Iranian pregnant women during the outbreak of COVID-19. Methods This descriptive-analytical cross-sectional study was performed on 205 pregnant women covered by Tabriz health centers in Iran. The sampling method used was cluster sampling. The data collection tool was the socio-demographic characteristics questionnaire and the DASS-21 (Depression, Anxiety and Stress Scale-21), which were completed online by pregnant women. The general linear model was used to determine the predictive factors of depression, anxiety and stress. Results The mean (SD) score of depression, stress, and anxiety were 3.91 (3.9), 6.22 (4.25), and 3.79 (3.39), respectively; the score range of 0 to 21. Depression, stress, and anxiety symptoms were observed in 32.7, 32.7, and 43.9% of the participants, respectively, with varying degrees from mild to very severe. Based on the adjusted general linear model, variables of education level, spouse’s job and marital life satisfaction were the predictors of depressive symptoms. Variables of spouse’s education level, spouse’s support, marital life satisfaction and the number of pregnancies were the predictive factors of anxiety symptoms and the variables of spouse’s education level, household income sufficiency, spouse’s support and marital life satisfaction were predictors of stress symptoms. Conclusions Considering the role of marital life satisfaction, high level of spouse’s education and income in reducing symptoms of stress, anxiety, and depression in pregnant women in critical situations such as the prevalence of COVID-19, it seems that using strategies to promote marital life satisfaction and socio-economic status can play an effective role in controlling anxiety and reducing stress and depression in pregnant women.

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“…39 In a study performed by Shapiro et al, 40 it was shown that premature birth was linked with the stress-related infections, but did not correlate with mental stress. In line with this, Ravid et al 41 demonstrated that anxiety was not associated with pregnancy complications. Contrarily, Ding et al 38 showed that maternal anxiety has a strong linkage with preterm delivery.…”

Section: Discussionmentioning

confidence: 75%

“…Notably, preterm delivery is associated with the early increase in CRH. 41 Besides, elevated levels of CRH can increase the concentration of cortisol and estrogen. Heightened ratios of estrogen to progesterone may disturb the uterus tranquility, which could in-crease the risk of premature birth.…”

Section: Discussionmentioning

confidence: 99%

The Correlation of SKA2 with Cortisol, IL-1β and Anxiety in Pregnant Women with the Risk of Preterm Delivery

Ijabi

Afrisham

Moradi-Sardareh

et al. 2020

Psychiatry Investig

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Objective The association between preterm birth (PTB), Spindle and Kinetochore Associated Complex Subunit 2 gene (SKA2), cortisol and anxiety have been shown, but in this study, we aimed to clarify whether the expression of the SKA2 gene plays a role in interleukin1β (IL-1β) level since increasing level of IL-1β is linked with PTB.Methods The case-control study was conducted on 49 and 51 women with preterm and term delivery, respectively. The score of anxiety was ranked according to the Spielberger state trait Anxiety Inventory. The concentration of cortisol and IL-1β was determined by the ELISA method. The expression of SKA2 gene was assessed by the quantitative real time real time polymerase chain reaction (qRT-PCR). The western blot analysis was also performed to confirm the expression of SKA2 at the levels of protein.Results The results showed that the gene/protein expression of SKA2, the concentrations of cortisol and IL-1β were significantly higher in the preterm than the term group. In the preterm group, the expression of SKA2 was positively correlated to the other factors including cortisol, IL-1β, and the degree of anxiety.Conclusion Our findings suggest that the expression of SKA2 was correlated positively to the levels of cortisol, IL-1β and the rate of anxiety in women with PTB.

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Is there an association between maternal anxiety propensity and pregnancy outcomes?

Cited by 21 publications

References 45 publications

Depressed mood and anxiety as risk factors for hypertensive disorders of pregnancy: a systematic review and meta-analysis

Depressed mood and anxiety as risk factors for hypertensive disorders of pregnancy: a systematic review and meta-analysis

Depression, stress, anxiety and their predictors in Iranian pregnant women during the outbreak of COVID-19

The Correlation of SKA2 with Cortisol, IL-1β and Anxiety in Pregnant Women with the Risk of Preterm Delivery

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