Is there an association between positive Strongyloides stercoralis serology and diabetes mellitus?

Mendonça, Suzan C.L.; Gonçalves-Pires, Maria do Rosário F.; Rodrigues, Raphael Silva; Ferreira, A.; Costa-Cruz, Júlia Maria

doi:10.1016/j.actatropica.2006.06.006

Cited by 56 publications

(43 citation statements)

References 22 publications

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“…The frequency of anti‐ S. stercorali s IgG in SLE patients treated with anthelmintics showed an increase of approximately 15 times compared to parasitological tests. This result is in agreement with other studies, where the frequency of S. stercoralis infection increased from 2.41% to 24.2% when comparing the parasitological with the immunological methods, respectively . The high frequency of anti‐ S. stercoralis IgG could be due to a previous exposure to infection or a low parasite load not diagnosed by stool examination …”

Section: Discussionsupporting

confidence: 92%

Strongyloides stercoralis infection in patients with systemic lupus erythematosus: diagnosis and prevention of severe strongyloidiasis

et al. 2015

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Aim: Strongyloides stercoralis infection is usually chronic and asymptomatic and may persist undiagnosed for decades. However, in immunocompromised individuals, the infection can cause hyperinfection and dissemination. Therefore, early diagnosis is essential to prevent severe forms of strongyloidiasis. The aims of this study were: (i) to evaluate the frequency of S. stercoralis infection in patients with systemic lupus erythematous (SLE) and (ii) to estimate specific immunoglobulins G (IgG) and E (IgE) production using an enzyme-linked immunosorbent assay (ELISA) method.Methods: Seventy-five SLE patients treated with prophylactic anthelmintic therapy were evaluated using the spontaneous sedimentation (SS), Baermann-Moraes (BM) and agar plate culture (APC) methods. Serum anti-S. stercoralis IgG and IgE antibodies were measured by ELISA.Results: Using parasitological methods, the frequency of intestinal parasites was 10.7%, whereas the frequency of S. stercoralis infection was 1.3%. The sensitivity of the ELISA to detect anti-S. stercoralis IgG and IgE was 80% and 76.9%, respectively. Both assays presented the same specificity of 96.7%. The frequency of anti-S. stercoralis IgG and IgE was 16% and 28%, respectively. Six patients were positive for both antibodies.Conclusions: Diagnostic approaches using high-sensitivity parasitological methods and the detection of specific antibodies are essential for the diagnosis of strongyloidiasis in immunocompromised patients. Early detection of infection can alter the course of the disease via appropriate treatment, preventing the occurrence of severe strongyloidiasis.

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Section: Discussionsupporting

confidence: 92%

Strongyloides stercoralis infection in patients with systemic lupus erythematosus: diagnosis and prevention of severe strongyloidiasis

et al. 2015

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“…91 Similarly, serological evidence of previous strongyloides infection was independently associated with a 60% lower prevalence of type 2 diabetes in an Indigenous Australian population with high rates of both, 92 although the opposite was found in a much smaller study in Brazil. 117 Strongyloides hyperinfection, a disseminated manifestation of the disease with a high parasite burden that mainly occurs in immuno compromised individuals, has been reported in patients with diabetes, [118][119][120] although these reports provide insufficient evidence of increased susceptibility.…”

Section: Helminth Infectionsmentioning

confidence: 99%

The global diabetes epidemic: what does it mean for infectious diseases in tropical countries?

Crevel

Vijver

Moore

2017

The Lancet Diabetes & Endocrinology

127

100

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Tropical countries are experiencing a substantial rise in type 2 diabetes, which is often undiagnosed or poorly controlled. Since diabetes is a risk factor for many infectious diseases, this increase probably adds to the large infectious disease burden in tropical countries. We reviewed the literature to investigate the interface between diabetes and infections in tropical countries, including the WHO-defined neglected tropical diseases. Although solid data are sparse, patients with diabetes living in tropical countries most likely face increased risks of common and health-care-associated infections, as well as infected foot ulcers, which often lead to amputation. There is strong evidence that diabetes increases the severity of some endemic infections such as tuberculosis, melioidosis, and dengue virus infection. Some HIV and antiparasitic drugs might induce diabetes, whereas helminth infections appear to afford some protection against future diabetes. But there are no or very scarce data for most tropical infections and for possible biological mechanisms underlying associations with diabetes. The rise in diabetes and other non-communicable diseases puts a heavy toll on health systems in tropical countries. On the other hand, complications common to both diabetes and some tropical infections might provide an opportunity for shared services-for example, for eye health (trachoma and onchocerciasis), ulcer care (leprosy), or renal support (schistosomiasis). More research about the interaction of diabetes and infections in tropical countries is needed, and the infectious disease burden in these countries is another reason to step up global efforts to improve prevention and care for diabetes.

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“…30 Autoimmune diseases such as diabetes mellitus may exacerbate complications and impact on the severity of Strongyloides infection. 32 …”

Section: Morbidity Caused By Strongyloidesmentioning

confidence: 99%

Strongyloidiasis – the most neglected of the neglected tropical diseases?

Olsen

Lieshout

Marti

et al. 2009

Transactions of the Royal Society of Tropical Medicine and Hygi

468

439

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a v a i l a b l e a t w w w . s c i e n c e d i r e c t . c o m j o u r n a l h o m e p a g e : h t t p : / / w w w . e l s e v i e r . c o m / l o c a t e / t r s t m h Summary Soil-transmitted helminths of the genus Strongyloides (S. fuelleborni and the more prevalent S. stercoralis) are currently believed to infect an estimated 30-100 million people worldwide. The health consequences of S. stercoralis infections range from asymptomatic light infections to chronic symptomatic strongyloidiasis. Uncontrolled multiplication of the parasite (hyperinfection) and potentially life-threatening dissemination of larvae to all internal organs is found among individuals with compromised immune system functions. This paper provides an overview of the current state of the art in relation to diagnostic methods for detecting the infection, the morbidity caused by the infection and the recommended treatment. It further discusses some of the reasons why this infection is so neglected and the consequence of this for the estimated global prevalence. The paper finally points to the gaps in our knowledge and future research needs related to this infection. As Strongyloides infections have the potential to develop into severe disease in certain population subgroups, untreated infections could cause serious problems in the community. Therefore, we need to carefully investigate this parasite in order to develop and implement effective control programmes. REVIEW Strongyloidiasis

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Is there an association between positive Strongyloides stercoralis serology and diabetes mellitus?

Cited by 56 publications

References 22 publications

Strongyloides stercoralis infection in patients with systemic lupus erythematosus: diagnosis and prevention of severe strongyloidiasis

Strongyloides stercoralis infection in patients with systemic lupus erythematosus: diagnosis and prevention of severe strongyloidiasis

The global diabetes epidemic: what does it mean for infectious diseases in tropical countries?

Strongyloidiasis – the most neglected of the neglected tropical diseases?

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