Is there a relationship between melanocytes and sensorineural hearing loss? Clinical evaluation of 51 patients with alopecia areata

Koçak, Hasan Emre; Acipayam, Ayse Sermin Filiz; Acıpayam, Harun; Erdoğan, B. Çakıl; Yildiz, Necibe; Küfeciler, Levent; Elbistanlı, Mustafa Suphi; Kaya, Kamïl Hakan

doi:10.1111/coa.13011

Cited by 8 publications

(17 citation statements)

References 10 publications

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“…[2][3][4] However, there are a limited number of studies evaluating hearing in AA patients, and the results of these studies are contradictory. [11][12][13][14] For instance, Uçak et al 11 and Shaheen et al 12 applied the pure tone audiometry test to AA patients and found a significant relationship between AA and hearing loss. Koçak et al 13 found that AA patients had increased cochlear dysfunction using the high-frequency audiometry test and the transient evoked otoacoustic emission test.…”

Section: Di̇scussi̇onmentioning

confidence: 99%

“…[11][12][13][14] For instance, Uçak et al 11 and Shaheen et al 12 applied the pure tone audiometry test to AA patients and found a significant relationship between AA and hearing loss. Koçak et al 13 found that AA patients had increased cochlear dysfunction using the high-frequency audiometry test and the transient evoked otoacoustic emission test. Furthermore, they blamed melanocyte damage in the inner ear on autoimmunity.…”

Section: Di̇scussi̇onmentioning

confidence: 99%

“…Auditory abnormalities have been demonstrated in vitiligo patients, and it has been reported that melanocyte damage not only affects the skin but also in other melanocyte‐containing areas 2‐4 . However, there are a limited number of studies evaluating hearing in AA patients, and the results of these studies are contradictory 11‐14 . For instance, Uçak et al 11 and Shaheen et al 12 applied the pure tone audiometry test to AA patients and found a significant relationship between AA and hearing loss.…”

Section: Di̇scussi̇onmentioning

confidence: 99%

“…In these studies, hearing was evaluated using the conventional pure tone audiometry (C‐PTA) test. Only Koçak et al 13 used the transient evoked otoacoustic emission test in their studies. Otoacoustic emission tests are used to evaluate the function of outer hair cells and detect early cochlear damage.…”

Section: Introductionmentioning

confidence: 99%

“…Only Koçak et al 13 To the best of our knowledge, auditory function in AA patients has not been assessed using the distortion product otoacoustic emission (DPOAE) test. Since melanocytes are located in the cochlea and the vestibular system of the inner ear, the vestibular function should also be evaluated to identify possible melanocyte damage in the inner ear.…”

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confidence: 99%

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There is no evidence of cochlear and vestibular melanocyte damage in patients with alopecia areata

Ertuğrul

Söylemez

2021

Int. J. Clin. Pract.

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Alopecia areata (AA) is an autoimmune disease that results in hair loss because of immune-mediated damage to the hair follicles.Other autoimmune diseases such as autoimmune thyroiditis, psoriasis, vitiligo, systemic lupus erythematosus and pernicious anaemia may accompany AA. It has been reported that the inner ear may be affected in these systemic autoimmune diseases, including AA. [1][2][3][4][5][6] It has been reported that follicular melanocytes are an important target for autoimmunity in AA patients. 7,8 Bulb melanocytes are essential for the follicular cycle and loss of melanocytes can result in hair loss. However, it is not clear whether melanocytes are primarily affected in the pathogenesis of AA or affected secondarily because of autoimmune damage in the hair follicle. Apart from the hair bulb, melanocytes are also found in the epidermis, the uveal tract and retinal pigment epithelium in the eye, the inner ear and the leptomeninges. 2 Just as melanocytes in the hair bulb play an important role in the follicular cycle, melanocytes in the inner ear are also

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Section: Di̇scussi̇onmentioning

confidence: 99%

Section: Di̇scussi̇onmentioning

confidence: 99%

Section: Di̇scussi̇onmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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There is no evidence of cochlear and vestibular melanocyte damage in patients with alopecia areata

Ertuğrul

Söylemez

2021

Int. J. Clin. Pract.

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Association of Sensorineural Hearing Loss in Patients With Alopecia Areata

et al. 2020

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Alopecia areata (AA) is a common autoimmune disease, leading to chronic and relapsing hair loss. 1 Current evidence suggests that follicular melanocytes may be an important target in the autoimmune process of AA. 2 In addition to their presence in the skin, melanocytes are also present as intermediate cells in the stria vascularis of the cochlea, which are critical for normal hearing. In patients with Vogt-Koyanagi-Harada disease, a rare autoimmune disorder that targets melanocytes, sensorineural hearing loss (HL) is a common complication in late-stage disease. Few studies have found audiological abnormalities in patients with AA 3,4 ; however, existing studies are limited by their cross-sectional designs and small sample sizes. This nationwide population-based cohort study was conducted to investigate the risk of HL in patients with AA using claims data from the National Health Insurance Research Database in Taiwan.Methods | This study was approved by the Institutional Review Board of Taipei Veterans General Hospital (2018-07-016AC). The institutional review board waived the requirement to obtain informed consent owing to the use of deidentified data (VGHIRB No.: 2018-07-016AC). We identified patients with AA diagnosed by dermatologists between January 1, 1998, and December 31, 2011. The diagnosis of AA was established according to the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) code 704.01. For each patient with AA, 10 controls were selected after matching for age, sex, monthly premium, and residence. The primary outcome assessed was new-onset HL, which was identified by ICD-9-CM code 389. The diagnosis of HL was established by otorhinolaryngologists and was classified into conductive HL (ICD-9-CM code 389.0), sensorineural HL (ICD-9-CM code 389.1), mixed HL (ICD-9-CM code 389.2), and others (ICD-9-CM codes 389.7, 389.8, and 389.9). Participants were observed until a diagnosis of HL, death, or December 31, 2013. Cox regression model was used to calculate adjusted hazard ratios with 95% CIs. Two-sided P values <.05 were considered statistically significant. Data management and analyses were performed using the Statistical Analysis System (SAS) software, version 9.4 (SAS Institute).

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Environmental Risk Factors, Protective Factors, and Biomarkers for Hearing Loss: An Umbrella Review

Xu,

Liao,

Zhang

et al. 2024

Otolaryngol.--head neck surg.

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ObjectiveWe aimed to investigate the potential environmental risk factors, protective factors, and biomarkers of hearing loss (HL), and establish a hierarchy of evidence.Data SourcesEmbase, PubMed, Cochrane Library, and Web of Science electronic database from inception to June 1, 2023.Review MethodsWe included meta‐analyses of observational studies of associations between HL and environmental risk factors, protective factors, or biomarkers. We calculated summary effect estimates, 95% confidence interval, heterogeneity I2 statistic, 95% prediction interval, small study effects, and excess significance biases.ResultsOf the 9211 articles retrieved, 60 eligible articles were included. The 60 eligible articles identified 47 potential environmental risk and protective factors (N = 4,123,803) and 46 potential biomarkers (N = 173,701). Evidence of association was convincing (class I) for rheumatoid arthritis (RA) and every 1 cm increase in height. Evidence of association was highly suggestive (class II) for human immunodeficiency virus (HIV), diabetes, cumulative noise exposure (CNE), smoking, congenital cytomegalovirus (CMV) infection, combined exposure to organic solvents and noise, non‐Gaussian noise exposure, each 1 kg increase in birth weight, noise exposure, and alopecia areata (AA).ConclusionIn this umbrella review, RA, every 1 cm increase in height, HIV, diabetes, CNE, smoking, congenital CMV infection, combined exposure to organic solvents and noise, non‐Gaussian noise exposure, each 1 kg increase in birth weight, noise exposure, and AA were strongly associated with HL.

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Is there a relationship between melanocytes and sensorineural hearing loss? Clinical evaluation of 51 patients with alopecia areata

Cited by 8 publications

References 10 publications

There is no evidence of cochlear and vestibular melanocyte damage in patients with alopecia areata

There is no evidence of cochlear and vestibular melanocyte damage in patients with alopecia areata

Association of Sensorineural Hearing Loss in Patients With Alopecia Areata

Environmental Risk Factors, Protective Factors, and Biomarkers for Hearing Loss: An Umbrella Review

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