Is there a possible relationship between gastric intestinal metaplasia and systemic arterial stiffness?

Kutluana, Ufuk; Kilciler, Ayse Guldem

doi:10.17235/reed.2019.5945/2018

Cited by 9 publications

(5 citation statements)

References 39 publications

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“…Gastric intestinal metaplasia is a known premalignant condition of the human stomach along the pathway to gastric cancer, at the histological level GIM is characterized by goblet and absorptive cells or columnar non-absorptive cells. GIM are the histopathologic entities that reflect the ordinal phases during the conversion of chronic gastric inflammation to carcinoma [14]. According to Correa's gastric cancer cascade, GIM is a major risk factor for gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical Expression of CDX2 as Early Biomarkers for Gastric Intestinal Metaplasia among Sudanese Patients with Chronic Gastritis

Mohamed,

Elemam,

Elsheikh

et al. 2023

SAR J Pathol Microbiol

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Background: Chronic gastric infection with Helicobacter pylori can cause intestinal metaplasia, a pathologic change that is frequently a precursor of gastric cancer; CDX2 has an essential role in the development and maintenance of intestinal differentiation in the gut and ectopic sites such as intestinal metaplasia of the stomach. Objective: This study aimed to investigate caudal-type home box (CDX2) Immuno expression as an early indicator for gastric intestinal metaplasia among Sudanese patients with chronic gastritis. Materials and methods: This is a descriptive retrospective cross-sectional study conducted at Atbara Medical Complex and El-MakNimr University Hospital at River Nile State in the period from 2019 to 2022. 140 archival paraffin tissue blocks were collected from patients diagnosed with chronic gastritis, immunohistochemistry was used to detect (CDX2 expression as an early indicator for gastric intestinal metaplasia. Results: From 140 samples, 80 were females (57.1 %) and 60 were males (42.9%), the patient's ages ranged from (12 to 97) with a mean age of (53.27) years, and age was categorized into three groups, less than 40 (27) (19.3%), 40- 60 (64) (45.7%), more than 60 (49) (35.0%). The prevalence of gastric intestinal metaplasia was (17.9%, while no statistically significant correlation of gastric intestinal metaplasia with gender and age as the P.value was (0.308 and 0.256) respectively. Conclusion: The development of gastric intestinal metaplasia as a premalignant condition of gastric carcinoma is important to detect this change at an early point to prevent and control gastric cancer.

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Section: Discussionmentioning

confidence: 99%

Immunohistochemical Expression of CDX2 as Early Biomarkers for Gastric Intestinal Metaplasia among Sudanese Patients with Chronic Gastritis

Mohamed,

Elemam,

Elsheikh

et al. 2023

SAR J Pathol Microbiol

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“…The latter was also independently associated with a high sensitivity C‐reactive protein level . A recent case‐control study performed by Kutluana et al showed that systemic arterial stiffness measured by pulse wave velocity was higher in patients with gastric intestinal metaplasia and atrophic gastritis, with lower B12 vitamin levels …”

Section: Cardiovascular Diseasesmentioning

confidence: 97%

Review:Helicobacter pyloriand extragastric diseases

2019

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In the last year, many studies have demonstrated a potential role of Helicobacter pylori in the pathogenic mechanisms of different extragastric diseases. While the role of H pylori in idiopathic thrombocytopenic purpura, idiopathic iron deficiency anemia, and vitamin B12 deficiency has already been demonstrated, there is growing evidence of other related conditions, especially cardiovascular, metabolic, and neurologic disorders, including neurodegenerative diseases. A summary of the results of the most relevant studies published over the last year on this attractive topic is presented in this review.

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“…This absorptive deficiency causes an increase in the circulant levels of homocysteine, which potentially contribute to the CAD development. In addition, a study conducted by Kutluana and Kilciler[ 133 ], 2019, demonstrated that the reduced absorption of above-mentioned nutrients due to atrophic gastritis and gastric intestinal metaplasia during H. pylori infection also lead to an increase in the arterial stiffness.…”

Section: Extragastric Manifestationsmentioning

confidence: 99%

Helicobacter pylori infection: Beyond gastric manifestations

Santos

Brito

Silva

et al. 2020

WJG

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Helicobacter pylori ( H. pylori ) is a bacterium that infects more than a half of world’s population. Although it is mainly related to the development of gastroduodenal diseases, several studies have shown that such infection may also influence the development and severity of various extragastric diseases. According to the current evidence, whereas this bacterium is a risk factor for some of these manifestations, it might play a protective role in other pathological conditions. In that context, when considered the gastrointestinal tract, H. pylori positivity have been related to Inflammatory Bowel Disease, Gastroesophageal Reflux Disease, Non-Alcoholic Fatty Liver Disease, Hepatic Carcinoma, Cholelithiasis, and Cholecystitis. Moreover, lower serum levels of iron and vitamin B12 have been found in patients with H. pylori infection, leading to the emergence of anemias in a portion of them. With regards to neurological manifestations, a growing number of studies have associated that bacterium with multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, and Guillain-Barré syndrome. Interestingly, the risk of developing cardiovascular disorders, such as atherosclerosis, is also influenced by the infection. Besides that, the H. pylori -associated inflammation may also lead to increased insulin resistance, leading to a higher risk of diabetes mellitus among infected individuals. Finally, the occurrence of dermatological and ophthalmic disorders have also been related to that microorganism. In this sense, this minireview aims to gather the main studies associating H. pylori infection with extragastric conditions, and also to explore the main mechanisms that may explain the role of H. pylori in those diseases.

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Is there a possible relationship between gastric intestinal metaplasia and systemic arterial stiffness?

Cited by 9 publications

References 39 publications

Immunohistochemical Expression of CDX2 as Early Biomarkers for Gastric Intestinal Metaplasia among Sudanese Patients with Chronic Gastritis

Immunohistochemical Expression of CDX2 as Early Biomarkers for Gastric Intestinal Metaplasia among Sudanese Patients with Chronic Gastritis

Review:Helicobacter pyloriand extragastric diseases

Helicobacter pylori infection: Beyond gastric manifestations

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