2003
DOI: 10.1161/01.hyp.0000069700.62727.c5
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Abstract-Hyperuricemia is associated with hypertension, vascular disease, renal disease, and cardiovascular events. In this report, we review the epidemiologic evidence and potential mechanisms for this association. We also summarize experimental studies that demonstrate that uric acid is not inert but may have both beneficial functions (acting as an antioxidant) as well as detrimental actions (to stimulate vascular smooth muscle cell proliferation and induce endothelial dysfunction). A recently developed expe… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

16
918
6
45

Year Published

2005
2005
2023
2023

Publication Types

Select...
5
2

Relationship

0
7

Authors

Journals

citations
Cited by 1,181 publications
(985 citation statements)
references
References 100 publications
16
918
6
45
Order By: Relevance
“…This raises the possibility that high UA levels may contribute to the pathogenesis of hypertension in humans, a concept supported by a number of studies showing an association between elevated serum UA levels and high blood pressure. [9][10][11] However most early studies were conducted either in rodent models, which have very different natural handling of the end purine metabolism, or in human populations already predisposed to vascular disorders, and thus do not provide a clear answer as to whether elevated serum UA is a cause or effect of such conditions. In this study, we used inosine, a natural metabolic precursor of UA, to raise serum urate levels in patients with MS to upper physiological levels of around 7-8 mg per 100 ml.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…This raises the possibility that high UA levels may contribute to the pathogenesis of hypertension in humans, a concept supported by a number of studies showing an association between elevated serum UA levels and high blood pressure. [9][10][11] However most early studies were conducted either in rodent models, which have very different natural handling of the end purine metabolism, or in human populations already predisposed to vascular disorders, and thus do not provide a clear answer as to whether elevated serum UA is a cause or effect of such conditions. In this study, we used inosine, a natural metabolic precursor of UA, to raise serum urate levels in patients with MS to upper physiological levels of around 7-8 mg per 100 ml.…”
Section: Discussionmentioning
confidence: 99%
“…A number of animal and human studies have been reported in which increased serum UA levels were found to be associated not only with an increased risk for hypertension but also with a variety of cardiovascular diseases (reviewed in Watanabe et al, 9 Johnson et al, 10 and Mene and Punzo 11 ). For example, rats treated with the urate oxidase inhibitor oxonic acid show increases in both serum UA level and blood pressure.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…1 Interestingly, hypertension is present in 30% of all patients with elevated levels of SUA, or hyperuricaemia. 2 Elevated SUA is present in 25% of untreated hypertensive subjects, in 50% of subjects taking diuretics, and in 475% of subjects with malignant hypertension.…”
Section: Introductionmentioning
confidence: 99%
“…2 Elevated SUA is present in 25% of untreated hypertensive subjects, in 50% of subjects taking diuretics, and in 475% of subjects with malignant hypertension. 1 In patients at risk for hypertension, higher levels of SUA may be due to the decrease in renal blood flow that accompanies the hypertensive state. 1 In addition, diet, genetics or other influences are also important modulators of SUA levels.…”
Section: Introductionmentioning
confidence: 99%