2019
DOI: 10.1590/0102-672020190001e1479
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Abstract: Background:Since 1990 it was proposed that distal and proximal location of colon cancer might follow different biological, epidemiology, pathology and prognosis, probably due to embryologic different development of the two segments of the colon, which may represent two separate disease entities. These differences might have consequences for the treatment of patients with colorectal cancer. Aim:To compare the characteristics between patients with right and left colon cancer, with severity and tumor characterist… Show more

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Cited by 10 publications
(11 citation statements)
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References 44 publications
(40 reference statements)
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“…Regarding survival analysis, we did not demonstrate any statistically signifi-cant differences in disease-free survival (DFS), progression-free survival (PFS), or overall survival (OS) between right and left sided colon cancer neither generally in all stages of disease nor in comparison of stage by stage and this was in accordance with the results of the study by Leonardo Alfonso Bustamante-Lopez et al which reported that colon cancer sidedness did not have a significant influence on survival [23]. Conversely, our results did not agree with results of the study by Christodoulidis G et al which concluded that left-sided colon cancer…”
Section: Discussionsupporting
confidence: 92%
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“…Regarding survival analysis, we did not demonstrate any statistically signifi-cant differences in disease-free survival (DFS), progression-free survival (PFS), or overall survival (OS) between right and left sided colon cancer neither generally in all stages of disease nor in comparison of stage by stage and this was in accordance with the results of the study by Leonardo Alfonso Bustamante-Lopez et al which reported that colon cancer sidedness did not have a significant influence on survival [23]. Conversely, our results did not agree with results of the study by Christodoulidis G et al which concluded that left-sided colon cancer…”
Section: Discussionsupporting
confidence: 92%
“…Our study did not demonstrate any significant association between tumor grade and the side of colon cancer which was in agreement with the study by Leonardo Alfonso Bustamante-Lopez et al [23]. On the other hand, this was in contrast with the study by Javier-A Cienfuegos and colleagues which reported that right-sided tumors were more significantly undifferentiated than left-sided tumors [16].…”
Section: Discussionsupporting
confidence: 92%
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“…In contrast, LCRCs tend to involve p53 mutations, and overexpression of vascular endothelial growth factor which are associated with an adverse prognosis and poor response to uorouracil-based chemotherapy [81] . RCRC has been associated with poorer survival outcomes as RCRC patients tend to be older [72,82,83] , and typically present with more advanced, poorly differentiated tumor, with at morphology, thus more challenging to detect, compared to LCRC patients [74,79,80] . Although CRC patients with tumors in the cecum until the hepatic exure have the highest survival rate compared to CRC patients with other cancer sites, the sample size is signi cantly smaller (8.1% of total CRC patients) than that of other cancer sites.…”
Section: Discussionmentioning
confidence: 99%
“…The biological, pathological, clinical, and prognostic differences between proximal (right-sided) and distal (left-sided) CRC localization have been clear for a long time [58]. But quite recently, due to the development of new research techniques, some genetic and molecular differences between the two groups have emerged [17].…”
Section: Right-sided and Left-sided Localizationmentioning
confidence: 99%