Is there a correlation between vaginal chlamydia infection and cervical smear abnormalities? A community‐based study in the Al‐Ain district, United Arab Emirates

Ghazal-Aswad, Saad; Badrinath, Padmanabhan; Osman, Nawal; Abdulkhalik, Samar; Raasclou, Tove

doi:10.1111/j.1447-0756.2006.00352.x

Cited by 5 publications

(4 citation statements)

References 17 publications

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“…11 Compared with antigen-based C. trachomatis prevalence, the observed 22.0% seroprevalence is 9 times higher than that reported in female patients attending primary and secondary care in UAE. 12 Compared with the nucleic acid amplification test-based prevalence, the overall C. trachomatis seroprevalence (22.0%) in this study is 4.9, 5.8, and 27.5 times higher than that estimated in general populations in the region of America (4.5%), in the region of Africa (3.8%), and in the region of Southeast Asia (0.8%), respectively. 18 This noticeable high burden of C. trachomatis suggests a substantial infection in this vulnerable population and adds to the totality of evidence on the potential impact of C. trachomatis on fertility.…”

Section: Discussioncontrasting

confidence: 70%

“…The prevalence of C. trachomatis IgG (19.0%) is comparable to that estimated in infertility clinic attendees (21.5%; 95% CI, 16.3–27.2) in the MENA region 11 . Compared with antigen-based C. trachomatis prevalence, the observed 22.0% seroprevalence is 9 times higher than that reported in female patients attending primary and secondary care in UAE 12 . Compared with the nucleic acid amplification test–based prevalence, the overall C. trachomatis seroprevalence (22.0%) in this study is 4.9, 5.8, and 27.5 times higher than that estimated in general populations in the region of America (4.5%), in the region of Africa (3.8%), and in the region of Southeast Asia (0.8%), respectively 18 .…”

Section: Discussionmentioning

confidence: 48%

“…However, the burden of exposure to chlamydia infection among fertility treatment–seeking populations remains poorly understood. In a recent meta-analysis 11 that investigated the epidemiology of C. trachomatis in different populations, including fertility clinic attendees, in the Middle East and North Africa (MENA) region, only one study from the UAE reporting C. trachomatis prevalence in female patients attending primary and secondary care was identified 12 . Given this apparent dearth of evidence, studies investigating exposure to C. trachomatis in different populations are needed.…”

mentioning

confidence: 99%

“…In a recent meta-analysis 11 that investigated the epidemiology of C. trachomatis in different populations, including fertility clinic attendees, in the Middle East and North Africa (MENA) region, only one study from the UAE reporting C. trachomatis prevalence in female patients attending primary and secondary care was identified. 12 Given this apparent dearth of evidence, studies investigating exposure to C. trachomatis in different populations are needed. This study measures the seroprevalence of past, current/acute, and active infection with C. trachomatis and identifies factors associated with seropositivity to C. trachomatis in infertility treatment–seeking patients in the Abu Dhabi Emirate, UAE.…”

mentioning

confidence: 99%

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Chlamydia trachomatis Seroepidemiology and Associated Factors in Fertility Treatment–Seeking Patients in the Abu Dhabi Emirate, United Arab Emirates

Abdo

Aslam²,

Suliansyah³

et al. 2023

Sexual Trans Dis

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This study was designed to investigate the seroepidemiology of and identify factors associated with exposure to Chlamydia trachomatis (C. trachomatis) in fertility treatment-seeking patients in Abu Dhabi Emirate, United Arab Emirates. Methods: A total of 308 fertility treatment-seeking patients were surveyed. Seroprevalence of past (IgG positive), current/acute (IgM positive), and active infection (IgA positive) with C. trachomatis was quantified. Factors associated with exposure to C. trachomatis were identified.Results: Overall, 19.0%, 5.2%, and 1.6% found to have past, acute/recent, and ongoing active infection with C. trachomatis, respectively. Overall, 22.0% of the patients were seropositive to any of the 3 to C. trachomatis antibodies. Male compared with female patients (45.7% vs. 18.9%, P < 0.001) and current/ex-smokers compared with nonsmokers (44.4% vs. 17.8%) had higher seropositivity. Patients with a history of pregnancy loss had higher seropositivity compared with other patients (27.0% vs. 16.8%), particularly recurrent pregnancy losses (33.3%). Current smoking (adjusted odds ratio [aOR], 3.8; 95% confidence interval, 1.32-11.04) and history of pregnancy loss (adjusted odds ratio [aOR], 3.0; 95% confidence interval, 1.5-5.8) were significantly associated with higher odds of exposure to C. trachomatis. Conclusions:The observed high seroprevalence of C. trachomatis, particularly in patients with a history of pregnancy loss, possibly indicates the contribution of C. trachomatis to the growing burden of infertility in the United Arab Emirates.

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Section: Discussioncontrasting

confidence: 70%

Section: Discussionmentioning

confidence: 48%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Chlamydia trachomatis Seroepidemiology and Associated Factors in Fertility Treatment–Seeking Patients in the Abu Dhabi Emirate, United Arab Emirates

Abdo

Aslam²,

Suliansyah³

et al. 2023

Sexual Trans Dis

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Epidemiology of Chlamydia trachomatis in the Middle East and north Africa: a systematic review, meta-analysis, and meta-regression

Smolak

Chemaitelly

Hermez

et al. 2019

The Lancet Global Health

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Background The epidemiology of Chlamydia trachomatis in the Middle East and north Africa is poorly understood. We aimed to provide a comprehensive epidemiological assessment of C trachomatis infection in the Middle East and north Africa. Methods We did a systematic review of C trachomatis infection as well as a meta-analysis and meta-regression of C trachomatis prevalence. We searched PubMed and Embase, as well as regional and national databases up to March 13, 2019, using broad search terms with no language or year restrictions. Any document or report including biological measures for C trachomatis prevalence or incidence was eligible for inclusion. We extracted all measures of current (genital or rectal), recent, and ever infection with C trachomatis. We estimated pooled average prevalence in different populations using random-effects meta-analysis. Factors associated with prevalence and sources of betweenstudy heterogeneity were determined using meta-regression. Findings We identified a total of 1531 citations, of which 255 reports contributed to 552 C trachomatis prevalence measures from 20 countries. No incidence measures were identified. Pooled prevalence of current genital infection was 3•0% (95% CI 2•3-3•8) in general populations, 2•8% (1•0-5•2) in intermediate-risk populations, 13•2% (7•2-20•7) in female sex workers, 11•3% (9•0-13•7) in infertility clinic attendees, 12•4% (7•9-17•7) in women with miscarriage, 12•4% (9•4-15•7) in symptomatic women, and 17•4% (12•5-22•8) in symptomatic men. Pooled prevalence of current rectal infection was 7•7% (4•2-12•0) in men who have sex with men. Substantial between-study heterogeneity was found. Multivariable meta-regression explained 29•0% of variation. Population type was most strongly associated with prevalence. Additional associations were found with assay type, sample size, country, and sex, but not with sampling methodology or response rate (about 90% of studies used convenience sampling and >75% had unclear response rate). There was no evidence for temporal variation in prevalence between 1982 and 2018. Interpretation C trachomatis prevalence in the Middle East and north Africa is similar to other regions, but higher than expected given its sexually conservative norms. High prevalence in infertility clinic attendees and in women with miscarriage suggests a potential role for C trachomatis in poor reproductive health outcomes in this region.

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Burden of Human Papillomavirus–Related Cervical Disease in the Extended Middle East and North Africa—A Comprehensive Literature Review

Seoud

2012

Journal of Lower Genital Tract Disease

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This article emphasizes the need for the introduction and standardization of screening practices in the region. Moreover, surveillance studies are needed to enable the identification of HPV type distribution and to determine the potential impact of the introduction of HPV vaccines. These socio-epidemiological data are of marked value to health care decision and policymakers in prioritizing available public health interventions.

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Is there a correlation between vaginal chlamydia infection and cervical smear abnormalities? A community‐based study in the Al‐Ain district, United Arab Emirates

Abstract: Although there have been earlier reports of an association between vaginal chlamydia and cervical abnormalities, our study does not provide evidence to support this association.

Cited by 5 publications

References 17 publications

Chlamydia trachomatis Seroepidemiology and Associated Factors in Fertility Treatment–Seeking Patients in the Abu Dhabi Emirate, United Arab Emirates

Chlamydia trachomatis Seroepidemiology and Associated Factors in Fertility Treatment–Seeking Patients in the Abu Dhabi Emirate, United Arab Emirates

Epidemiology of Chlamydia trachomatis in the Middle East and north Africa: a systematic review, meta-analysis, and meta-regression

Burden of Human Papillomavirus–Related Cervical Disease in the Extended Middle East and North Africa—A Comprehensive Literature Review

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