Is There a Connection Between the Concentration of Cholesterol Circulating in Plasma and the Rate of Neuritic Plaque Formation in Alzheimer Disease?

Lipid-Lowering Agents and the Risk of Cognitive Impairment That Does Not Meet Criteria for Dementia, in Relation to Apolipoprotein E Status

“…Once again, however, we find no support for indication bias underlying the findings [3,37] . Indeed, these observational data support the need for un- dertaking an experiment -for example by adding cognitive tests, and a more conventional approach to dementia diagnosis, to any new statin studies.…”

Lipid-Lowering Agents and the Risk of Cognitive Impairment That Does Not Meet Criteria for Dementia, in Relation to Apolipoprotein E Status

“…Once again, however, we find no support for indication bias underlying the findings [3,37] . Indeed, these observational data support the need for un- dertaking an experiment -for example by adding cognitive tests, and a more conventional approach to dementia diagnosis, to any new statin studies.…”

Serum lipids and memory in a population based cohort of middle age women

“…[31][32][33] It is not certain, however, that lowered cholesterol is causative, as the association is stronger for less potent statins 31 and may not occur in other classes of lipid lowering agents, 32 and because confounding by indication or cessation bias was not always confidently excluded in reported studies. 34 In the MWMHP cohort, we observed no association between statin use and memory independent of lipid concentrations; speculatively, anti-inflammatory and antioxidant actions of statins are more relevant to dementia than lipid lowering effects. 35 The relation between cholesterol and memory in the elderly may differ from that in younger or middle age adults, where prevalences of atherosclerosis and dementia are lower.…”

Lipid lowering agents are associated with a slower cognitive decline in Alzheimer's disease

“…These specialist/memory centre based diagnoses answer the criticism made by Birkenhager et al, 39 based on the findings of Jick's study. 24 However, in this observational study, confusion between the efficacy of the drugs and the indications for which they are prescribed cannot be ruled out, 37 and a causal nature of the association is not proven.…”

Lipid-Lowering Agents and the Risk of Cognitive Impairment That Does Not Meet Criteria for Dementia, in Relation to Apolipoprotein E Status

“…Once again, however, we find no support for indication bias underlying the findings [3,37] . Indeed, these observational data support the need for un- dertaking an experiment -for example by adding cognitive tests, and a more conventional approach to dementia diagnosis, to any new statin studies.…”

Serum lipids and memory in a population based cohort of middle age women

“…[31][32][33] It is not certain, however, that lowered cholesterol is causative, as the association is stronger for less potent statins 31 and may not occur in other classes of lipid lowering agents, 32 and because confounding by indication or cessation bias was not always confidently excluded in reported studies. 34 In the MWMHP cohort, we observed no association between statin use and memory independent of lipid concentrations; speculatively, anti-inflammatory and antioxidant actions of statins are more relevant to dementia than lipid lowering effects. 35 The relation between cholesterol and memory in the elderly may differ from that in younger or middle age adults, where prevalences of atherosclerosis and dementia are lower.…”

Lipid lowering agents are associated with a slower cognitive decline in Alzheimer's disease

“…These specialist/memory centre based diagnoses answer the criticism made by Birkenhager et al, 39 based on the findings of Jick's study. 24 However, in this observational study, confusion between the efficacy of the drugs and the indications for which they are prescribed cannot be ruled out, 37 and a causal nature of the association is not proven.…”

Lipid-Lowering Agents and the Risk of Cognitive Impairment That Does Not Meet Criteria for Dementia, in Relation to Apolipoprotein E Status

“…Once again, however, we find no support for indication bias underlying the findings [3,37] . Indeed, these observational data support the need for un- dertaking an experiment -for example by adding cognitive tests, and a more conventional approach to dementia diagnosis, to any new statin studies.…”

Serum lipids and memory in a population based cohort of middle age women

“…[31][32][33] It is not certain, however, that lowered cholesterol is causative, as the association is stronger for less potent statins 31 and may not occur in other classes of lipid lowering agents, 32 and because confounding by indication or cessation bias was not always confidently excluded in reported studies. 34 In the MWMHP cohort, we observed no association between statin use and memory independent of lipid concentrations; speculatively, anti-inflammatory and antioxidant actions of statins are more relevant to dementia than lipid lowering effects. 35 The relation between cholesterol and memory in the elderly may differ from that in younger or middle age adults, where prevalences of atherosclerosis and dementia are lower.…”

Lipid lowering agents are associated with a slower cognitive decline in Alzheimer's disease

“…These specialist/memory centre based diagnoses answer the criticism made by Birkenhager et al, 39 based on the findings of Jick's study. 24 However, in this observational study, confusion between the efficacy of the drugs and the indications for which they are prescribed cannot be ruled out, 37 and a causal nature of the association is not proven.…”