Is the Self-counting of Moles a Valid Method of Assessing Melanoma Risk?

Mikkilineni, Radha; Weinstock, Martin A.

doi:10.1001/archderm.136.12.1550

Cited by 13 publications

(8 citation statements)

References 9 publications

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“…The majority of studies on nevus counts have shown substantial agreement between nevus self-counts and dermatologist-counts [42–44]. The Spearman correlation coefficient was 0.91 between nevus counts by patients and physicians, suggesting quite a good correlation between the two measurements [45]. These previous reports support the reliability and validity of self-reported skin characteristics.…”

Section: Discussionmentioning

confidence: 71%

A functional SNP in the MDM2 promoter, pigmentary phenotypes, and risk of skin cancer

Nan

Qureshi

Hunter

et al. 2008

Cancer Causes Control

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The MDM2 oncoprotein is a key negative regulator of the tumor suppressor p53. A functional MDM2 single nucleotide polymorphism (SNP309) in the promoter region increases the affinity of transcription activator Sp1 for the MDM2 gene promoter, resulting in higher expression of MDM2 and thus inhibition of p53 transcriptional activity. UV-induced p53 activation promotes cutaneous transient pigmentation, and the common p53 Arg72Pro polymorphism alters the protein's transcriptional activity. We evaluated the effect of the MDM2 SNP309 and its interaction with the p53 Arg72Pro polymorphism on pigmentary phenotypes and skin cancer risk in a nested case-control study within the Nurses' Health Study (NHS) among 219 melanoma cases, 286 squamous cell carcinoma (SCC) cases, 300 basal cell carcinoma (BCC) cases, and 873 controls, and among controls from other studies. We found that the G allele of the MDM2 SNP309 was inversely associated with the presence/absence of moles on the arm among 3207 women pooled from controls of three nested case-control studies within the NHS. Compared with the MDM2 SNP309 T/T genotype, adjusted odds ratios (ORs) of having moles on the arms for T/G and G/G genotypes were 0.92 (95% confidence interval (CI), 0.78-1.08) and 0.68 (95%CI, 0.53-0.87), respectively (P, trend, 0.005). We observed suggestive evidence of the association between the carriage of the MDM2 SNP309 G allele and childhood tanning tendency (adjusted OR, 1.30; 95% CI,. No significant associations were found between the MDM2 SNP309 and any of the three types of skin cancer. For SCC, the trend of increased risk across the three genotypes of MDM2 was stronger among p53 Pro carriers (p, trend, 0.05) than p53 Arg/Arg wildtype group (p, trend, 0.99; p, interaction, 0.07). These results provide evidence for the potential involvement of MDM2 SNP309 in pigmentary traits.

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Section: Discussionmentioning

confidence: 71%

A functional SNP in the MDM2 promoter, pigmentary phenotypes, and risk of skin cancer

Nan

Qureshi

Hunter

et al. 2008

Cancer Causes Control

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“…However, previous studies have evaluated the validity of self‐reported information on nevus counts, and the majority found substantial agreement between nevus self‐counts and dermatologist counts . In one study, the Spearman's correlation coefficient was 0.91 between the two measurements . In our cohorts, the ordinal variable of nevus count is a highly significant predictor of melanoma risk .…”

Section: Discussionmentioning

confidence: 88%

Cutaneous nevi and internal cancer risk: Results from two large prospective cohorts of US women

Giovannucci

et al. 2019

Intl Journal of Cancer

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Elevated cutaneous nevus number has been linked to longer telomeres. Recently, a large systematic Mendelian randomization study identified a significant positive association between telomere length and risk of cancer. Here, we hypothesized that higher nevus count, as a phenotypic marker of longer telomere, may be associated with increased risk of internal cancer, and prospectively examined the association between nevus count and total as well as site-specific cancer risk among participants in the Nurses' Health Study (NHS, 1986(NHS, -2012 and the Nurses' Health Study 2 (NHS2, 1989-2013) using Cox proportional hazards models. During 3,900,264 person-years of follow-up, we documented a total of 23,004 internal cancer cases (15,484 in the NHS and 7,520 in the NHS2). Compared to participants who had no nevi, the multivariate hazard ratios of total cancer (excluding skin cancer) were 1.06 (95% confidence interval [CI], 1.03-1.09) for women with 1-5 nevi, 1.08 (95% CI, 1.03-1.15) for those who had 6-14 nevi and 1.19 (95% CI, 1.05-1.35) for those with 15 or more nevi (p trend <0.0001). Moreover, because nevus count has been associated with risk of breast cancer previously, we conducted a secondary analysis by excluding breast cancer from the outcomes of interest. The results were very similar to those of our primary analysis. For individual cancer, most of the associations with nevus count were positive but not statistically significant. In conclusion, we identified the number of cutaneous nevi as a phenotypic marker associated with internal cancer risk, which may be explained by telomere biology.Additional Supporting Information may be found in the online version of this article.

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“…We did not verify the self-report of common nevi and did not collect information on nevi at other body parts and the specific types. Previous studies have shown a substantial agreement between nevus self-counts and the gold standard measure, clinical assessment by dermatologists [34][35][36] . The number of moles on arms has been used as a proxy for the total body mole counts and systematic melanoma risk in studies based on NHS and other resources 37,38 .…”

Section: Discussionmentioning

confidence: 93%