Is the platelet-to-lymphocyte ratio a new prognostic marker in multiple myeloma?

Abstract

BACKGROUND: Recent reports showed neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR), as a predictor of progression-free survival (PFS) and overall survival (OS) in various malignancies. MATERIALS AND METHODS: We retrospectively examined the PLR, NLR, and MLR in a cohort of 186 newly diagnosed multiple myeloma (MM) patients. This study investigated the prognostic relevance of NLR, PLR, and MLR in MM patients. NLR, PLR, and MLR were calculated from whole blood counts before therapy. The Kaplan–Meier curves and multivariate Cox models were used for the evaluation of survival. RESULTS: Applying cutoff of 1.9 (NLR), 120.00 (PLR), and 0.27 (MLR), decreased PLR showed a negative impact on the outcome. Decreased PLR is an independent predictor for PFS and OS. There were no significant differences in median survival between the high and low NLR (P = 0.80) and MLR (P = 0.87) groups. CONCLUSIONS: In this study, thrombocytopenia and low PLR are associated with poor survival in MM patients does this P value apply to thrombocytopenia or low PLR and may serve as the cost-effective prognostic biomarker.

The Prognostic Significance of the Neutrophil-to-Lymphocyte Ratio in Patients with Multiple Myeloma: A Pilot Study

“…Studies have demonstrated that higher stages of the disease tend to correlate with a poor prognosis (6,8,9,12). In our study, consistent with the previous results, there was a statistically significant correlation between the ISS stage and mortality.…”

“…Recent studies showed that a decreased PLT level predicts poor prognosis in MM patients (6,8,9,22). In our study, no significant correlation was found between PLT level and both mortality and OS in patients with MM.…”

Prognostic significance of blood inflammatory biomarkers NLR, PLR, and LMR in cancer—A protocol for systematic review and meta-analysis

“…[14,15] This abundance of literature has also led to the publication of multiple systematic review and meta-analysis studies regarding this topic. [16,17] However, no systematic review or meta-analysis study published till-date, has investigated;…”

Does the platelet‑to‑lymphocyte ratio have a prognostic effect in patients with myelodysplastic syndrome?

“…Therefore, many published studies have investigated the effect of PLR on hematologic and nonhematologic malignancies and reported that increased PLR is associated with poor prognosis and negative impact on survival (24)(25)(26)(27). However, low PLR in multiple myeloma, one of the hematologic malignancies involving suppression of thrombopoiesis caused by infl ammatory effect, was found to be associated with poor prognosis (28). This is a known effect of disease pathophysiology in MDS.…”