Is the correction of micronutrient deficiencies the next step in heart failure management?

Girerd, Nicolas

doi:10.1111/joim.13455

Cited by 3 publications

(1 citation statement)

References 8 publications

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“…While a sufficient supply of fatty acids, glucose and amino acids are crucial for ATP generation, micronutrients, including coenzyme Q10, zinc, copper, selenium and iron, may also have a strong impact on the functionality of the respiratory complexes. This issue has been extensively reviewed elsewhere [62]. Defects or dysfunction of respiratory complexes may promote hypertrophic remodeling and HF, as shown in mice with genetic inhibition of complex I [63].…”

Section: Impaired Oxidative Phosphorylationmentioning

confidence: 99%

Targeting Mitochondrial Metabolism to Save the Failing Heart

Schenkl

Heyne

Doenst

et al. 2023

Life

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Despite considerable progress in treating cardiac disorders, the prevalence of heart failure (HF) keeps growing, making it a global medical and economic burden. HF is characterized by profound metabolic remodeling, which mostly occurs in the mitochondria. Although it is well established that the failing heart is energy-deficient, the role of mitochondria in the pathophysiology of HF extends beyond the energetic aspects. Changes in substrate oxidation, tricarboxylic acid cycle and the respiratory chain have emerged as key players in regulating myocardial energy homeostasis, Ca2+ handling, oxidative stress and inflammation. This work aims to highlight metabolic alterations in the mitochondria and their far-reaching effects on the pathophysiology of HF. Based on this knowledge, we will also discuss potential metabolic approaches to improve cardiac function.

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Section: Impaired Oxidative Phosphorylationmentioning

confidence: 99%

Targeting Mitochondrial Metabolism to Save the Failing Heart

Schenkl

Heyne

Doenst

et al. 2023

Life

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LLL 44-4 : Micronutrients in acute disease and critical illness

de Man,

Amrein,

Casaer

et al. 2024

Clinical Nutrition ESPEN

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The relevance of the development of food products enriched with trace elements for diet therapy in cardiovascular diseases

Yashin,

Petrov

2023

Food systems

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Cardiovascular diseases (CVDs) remain to be the leading cause of death in the whole world. The structure of nutrition of the population and diet therapy are extremely important factors for prevention and treatment of CVDs. Results of the scientific research obtained over the last decade give new data on the role of certain micronutrients in the physiological processes and pathogenesis of these groups of diseases. The aim of this research was to study the current role of certain trace elements (magnesium, zinc and copper) in the pathogenesis of diseases, including assessment of the level of their intake in different countries. Furthermore, the review considers the necessity of creating new functional products to use in diet therapy for patients with cardiovascular diseases. It includes publications in Russian and English for the period of 2011 to 2022 from open databases PubMed, ScienceDirect, Scopus, CyberLeninka, eLIBRARY as well as from open Internet sources. The research work carried out during preparation of this review was directed to studying the sphere of CVD prevention, role and relevance of the development of functional foods enriched with micronutrients. The data on the dysfunctions of the human body caused by the deficiency of zinc, copper and magnesium intake are presented. The current physiological daily norms for intake of these trace elements in different countries are given, and the dynamics of changes in the norms of intake over the last twenty years is shown. The review summarizes new data on the correlation between the risk of emergence of certain CVD types and the specific features of assimilation of the above-mentioned trace elements. The regulatory conditions acting on the RF territory for introducing trace elements into food products are analyzed. Based on the obtained results, conclusions were made regarding the relevance of the further development of functional foods that do not require changes in the traditional food behavior model.

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Is the correction of micronutrient deficiencies the next step in heart failure management?

Cited by 3 publications

References 8 publications

Targeting Mitochondrial Metabolism to Save the Failing Heart

Targeting Mitochondrial Metabolism to Save the Failing Heart

LLL 44-4 : Micronutrients in acute disease and critical illness

The relevance of the development of food products enriched with trace elements for diet therapy in cardiovascular diseases

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