Is SARS Just ARDS?

Could there be a link between oral hygiene and the severity of SARS-CoV-2 infections?

“…15 This suggests that patients are more likely to die from post-viral infection complications than from COVID-19. ARDS was also the biggest cause of death for SARS-CoV 16 and MERS-CoV infections, 17 further confirming the connection between the three coronaviruses. As of 3 March 2020, COVID-19 was predicted to have a 3.4% mortality rate.…”

2020 Year in Review: Mechanical Ventilation During the First Year of the COVID-19 Pandemic

“…188,189 Successful NIV therapy was characterized by marked improvement in P aO 2 /F IO 2 and decreased breathing frequency after initiation (particularly < 30 breaths/min) along with sustained P aO 2 =F IO 2 > 150 mm Hg over the course of therapy. 189 The characteristics of NIV use and outcomes in COVID-19-associated ARDS appear to be similar to those observed in non-COVID-19-associated ARDS in terms of the main drivers of therapeutic failure: (1) poor baseline oxygenation (and absence of sustained improvement with therapy), (2) comorbidities, and (3) illness severity and the presence of multiple-organ system dysfunction. The fact that several of these factors also drive mortality during invasive ventilation should be considered when judging the relative efficacy of either therapy.…”

“…The basis for this was established in 2003 when the term "severe acute respiratory syndrome" (SARS) was coined rather than an alternative name in which ARDS was a salient feature. 2 Naming has consequences. Now with the perspective of time, the accruement of experience, data, and waning emotions, this narrative review is focused on our current understanding of COVID-19 associated respiratory failure and its response to mechanical ventilation.…”

Flavonol morin targets host ACE2, IMP-α, PARP-1 and viral proteins of SARS-CoV-2, SARS-CoV and MERS-CoV critical for infection and survival: a computational analysis

“…A meta-analysis of seven studies has revealed that COPD patients have a significantly higher risk of developing severe COVID-19 complications ( https://www.medicalnewstoday.com/articles/covid-19-and-copd#danger ). Therefore, it would be worthwhile to evaluate the efficacy of morin in COPD patients harboring COVID-19 infection (Jih, 2005 ; Rubenfeld, 2003 ).…”