Is placental alkaline phosphatase (PLAP) a useful marker for seminoma?

Diagnostic value of markers M2A, OCT3/4, AP‐2γ, PLAP and c‐KIT in the detection of extragonadal seminomas

“…The latter was elevated in only seven of 18 (39%) patients examined and, furthermore, we found no correlation between serum levels and tissue expression of PLAP (compare Table 1). These findings are in line with previous clinical studies which have shown that serum PLAP assay is of limited use in patients with seminomas 25 . Thus, it would be of general interest to establish a new sensitive and specific serum marker for seminomas, especially in order to assist follow‐up in patients with progressive disease.…”

Diagnostic value of markers M2A, OCT3/4, AP‐2γ, PLAP and c‐KIT in the detection of extragonadal seminomas

“…The latter was elevated in only seven of 18 (39%) patients examined and, furthermore, we found no correlation between serum levels and tissue expression of PLAP (compare Table 1). These findings are in line with previous clinical studies which have shown that serum PLAP assay is of limited use in patients with seminomas 25 . Thus, it would be of general interest to establish a new sensitive and specific serum marker for seminomas, especially in order to assist follow‐up in patients with progressive disease.…”

Tobacco Smoking Leads to Extensive Genome-Wide Changes in DNA Methylation

“…Quantitative variations of circulating alkaline phosphatase concentrations are associated with premature birth [30], [31], low birth weight [32], [33] and pre-eclampsia [34]. Serum ALPP and ALPPL2 enzyme levels are increased up to 10-fold in 80% of cigarette smokers [35]–[37] and were shown to be elevated in patients with a number of cancers, especially seminoma [38], [39].…”

The Value of Tumor Markers in Testicular Seminomas

“…In monitoring dis ease, P1AP may still be a valuable method in smokers. Unfortunately, therefore the positive predictive value of P1AP is limited [34], In our hand, it was found to be only 10% with smokers included and 23% for nonsmokers. Moreover, even generally accepted markers such as HCG and LDH were associated with active seminoma in fol low-up in only 27 and 22%, respectively.…”

Diagnostic value of markers M2A, OCT3/4, AP‐2γ, PLAP and c‐KIT in the detection of extragonadal seminomas

“…The latter was elevated in only seven of 18 (39%) patients examined and, furthermore, we found no correlation between serum levels and tissue expression of PLAP (compare Table 1). These findings are in line with previous clinical studies which have shown that serum PLAP assay is of limited use in patients with seminomas 25 . Thus, it would be of general interest to establish a new sensitive and specific serum marker for seminomas, especially in order to assist follow‐up in patients with progressive disease.…”

Tobacco Smoking Leads to Extensive Genome-Wide Changes in DNA Methylation

“…Quantitative variations of circulating alkaline phosphatase concentrations are associated with premature birth [30], [31], low birth weight [32], [33] and pre-eclampsia [34]. Serum ALPP and ALPPL2 enzyme levels are increased up to 10-fold in 80% of cigarette smokers [35]–[37] and were shown to be elevated in patients with a number of cancers, especially seminoma [38], [39].…”

The Value of Tumor Markers in Testicular Seminomas

“…In monitoring dis ease, P1AP may still be a valuable method in smokers. Unfortunately, therefore the positive predictive value of P1AP is limited [34], In our hand, it was found to be only 10% with smokers included and 23% for nonsmokers. Moreover, even generally accepted markers such as HCG and LDH were associated with active seminoma in fol low-up in only 27 and 22%, respectively.…”

Diagnostic value of markers M2A, OCT3/4, AP‐2γ, PLAP and c‐KIT in the detection of extragonadal seminomas

“…The latter was elevated in only seven of 18 (39%) patients examined and, furthermore, we found no correlation between serum levels and tissue expression of PLAP (compare Table 1). These findings are in line with previous clinical studies which have shown that serum PLAP assay is of limited use in patients with seminomas 25 . Thus, it would be of general interest to establish a new sensitive and specific serum marker for seminomas, especially in order to assist follow‐up in patients with progressive disease.…”

Tobacco Smoking Leads to Extensive Genome-Wide Changes in DNA Methylation

“…Quantitative variations of circulating alkaline phosphatase concentrations are associated with premature birth [30], [31], low birth weight [32], [33] and pre-eclampsia [34]. Serum ALPP and ALPPL2 enzyme levels are increased up to 10-fold in 80% of cigarette smokers [35]–[37] and were shown to be elevated in patients with a number of cancers, especially seminoma [38], [39].…”

The Value of Tumor Markers in Testicular Seminomas

“…In monitoring dis ease, P1AP may still be a valuable method in smokers. Unfortunately, therefore the positive predictive value of P1AP is limited [34], In our hand, it was found to be only 10% with smokers included and 23% for nonsmokers. Moreover, even generally accepted markers such as HCG and LDH were associated with active seminoma in fol low-up in only 27 and 22%, respectively.…”