Is Parkinson’s Disease Associated with Increased Mortality, Poorer Outcomes Scores, and Revision Risk After THA? Findings from the Swedish Hip Arthroplasty Register

Abstract

Background Neurological conditions such as Parkinson's disease are commonly accepted as a risk factor for an increased likelihood of undergoing revision surgery or death after THA. However, the available evidence for an association between Parkinson's disease and serious One of the authors (MM) reports grants from Zimmer Biomet (Warsaw, IN, USA), personal fees from Zimmer Biomet, and grants from Link Sweden, outside the submitted work. Each author certifies that his or her institution approved the human protocol for this investigation and that all investigations were conducted in conformity with ethical principles of research.

Functional outcomes after total joint arthroplasty are related to the severity of Parkinson’s disease: a mid-term follow-up

“…Two of our patients suffered from transient delirium and were controlled with olanzapine, which confirmed that orthopedic surgery could induce a cognitive decline in PD patients [20]. Recently, some database studies [21–26] showed both TKA and THA in PD patients provide a higher complication rate, longer LOS, and higher charges than the controlled cohort. One study [27] considered the higher complication rate of PD patients was associated with cardiovascular and psychiatric comorbidity.…”

Clinical outcomes in elective total hip arthroplasty in Parkinson’s disease: a systematic review of the literature

“…Rondon et al 26 employed the longest follow-up; 10-year implant survivorship was significantly worse in PD patients compared to elective THA in matched controls (p = 0.0024). In concordance, Wojtowicz et al 22 showed patients with PD were at higher risk of revision one year (1.03% vs. 2.10%, p = 0.256) and nine years (5.44% vs. 1.75%, p = 0.001) after the primary procedure compared to matched controls. The five-year survival rate in the PD population was reported in two studies 23 , 24 (79.7% and 93%).…”

“…Mortality and surgical site infection for all eligible studies reporting crude rate of events are presented in Tables 3 and 4 . In the most recently published study, Wojtowicz et al 22 reported no difference in mortality at 90 days and one year between PD and non-PD patients undergoing total hip arthroplasty (THA) (risk of death at 90 days, 0.62% vs. 0.61%, p = 0.998, and at one year 2.11% vs. 2.56%, p = 0. 670).…”

“…In concordance, Newman et al 19 reported no statistical difference in the occurrence of SSI among THA performed in patients with PD and matched controls (p = 0.722). Wojtowicz et al 22 reported that 22% (95% CI, 11–40%) of the PD patients needing revision was due to a periprosthetic infection, whereas the respective percentage in the matched-control group was 2% (95% CI, 0–11%).…”

coder: An R package for code-based item classification and categorization

“…coder has been used in ongoing, as well as in previously published research (Berg et al, 2018;Erik Bülow et al, 2020P. H. J. Cnudde et al, 2018;Hansson et al, 2020;Jawad et al, 2019;Nemes et al, 2018;Wojtowicz et al, 2019).…”