Is ovarian stimulation affecting endometrial NK cell response during implantation window?

Azpiroz, A.; Junovich, G.; Ferrer, Christian; Pasqualini, A.; Pasqualini, S.; Gutiérrez, Gabriela

doi:10.1016/j.jri.2011.06.062

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“…40 These changes occurring at a genetic level are thought to be implicated in overcoming the observed asynchrony of the endometrium and embryo stage in repeated IVF implantation failures, following COH. 13,17,69 The Neoangiogenesis Theory Typically, trauma stimulates angiogenesis. 54 An induced injury can provide an enhanced angiogenic environment, enriched with cytokines and growth factors, known to be crucial for a normal trophoblast invasion and retention of the embryo.…”

Section: Gene Expression Theory: Synchronization Of Embryo and Endometriummentioning

confidence: 99%

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Potential Pathophysiological Mechanisms of the Beneficial Role of Endometrial Injury in In Vitro Fertilization Outcome

et al. 2014

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Successful embryo implantation is a complex process that involves multiple biological mechanisms and reciprocal interactions between the embryo and the proliferated endometrium. In this review, we provide an informative contribution on the pathways underlying the beneficial nature of endometrial injury toward improving implantation rates of embryos conceived and through in vitro fertilization. The evidence published to date are in favor of inducing local endometrial injury in the preceding cycle of ovarian stimulation to improve pregnancy outcomes in women with unexplained and recurrent implantation failure. Endometrial injury triggers a series of biological responses but the findings suggest that no particular pathway is solely adequate to explain the association between trauma and improved pregnancy rates rather than a cluster of events in response to trauma which benefits embryo implantation in ways both known and unknown to the scientific community.

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Section: Gene Expression Theory: Synchronization Of Embryo and Endometriummentioning

confidence: 99%

Section: Possible Pathwaysmentioning

confidence: 99%

Potential Pathophysiological Mechanisms of the Beneficial Role of Endometrial Injury in In Vitro Fertilization Outcome

et al. 2014

View full text Add to dashboard Cite

show abstract

Is ovarian stimulation affecting endometrial NK cell response during implantation window?

Cited by 1 publication

References 0 publications

Potential Pathophysiological Mechanisms of the Beneficial Role of Endometrial Injury in In Vitro Fertilization Outcome

Potential Pathophysiological Mechanisms of the Beneficial Role of Endometrial Injury in In Vitro Fertilization Outcome

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