Is neck dissection needed in squamous-cell carcinoma of the maxillary gingiva, alveolus, and hard palate? A multicentre Italian study of 65 cases and literature review

Metastatic pattern in squamous cell carcinoma of the hard palate and maxillary alveolar ridge: clinical experience and review of the literature

“…Similar to recent reports about the role of histologic risk factors [26], in our study, perineural or lymphovascular invasion was significantly associated with initial positive nodes. The rate of 13.3% of histopathological confirmed lymph node metastases recorded in the present study is below the listed range of 17-54% specifically mentioned for maxillary OSCC in related cohort studies [11,19,22,23,[27][28][29][30]. In 9.4% of patients with one-sided END (3/32), recurrent metastases occurred in the non-dissected side of the neck, that are assigned to initial clinical occult metastases by some authors and occur in 10-30% of the time [22,27,28,31], such as histopathological detected occult metastases after END [8,19,20,22,30] (Table 5).…”

“…Furthermore, in sagittal extent, the regional recurrence rate in tumors with sole or comprehensive involvement of the posterior maxilla was higher but showed no clear difference (17.6 vs. 7.1%, p = 0.349) as opposed to isolated involvement in the anterior region. Similarly, Beltramini et al reported a higher metastatic rate of 37% (2/7) in the dorsal hard palate compared to 10% (2/20) in the anterior region [28].…”

Clinicopathological Characteristics and Outcome Predictors in Squamous Cell Carcinoma of the Maxillary Gingiva and Hard Palate

“…3 However, elective neck dissection has been shown to be beneficial during early-stage oral SCC, 4,5 and according to recent research, patients who do not undergo elective neck dissection have a higher risk of lymph node metastasis. [6][7][8] The hard palate and maxillary gingiva are anatomically adjacent to each other, and SCCs in these areas have similar disease behaviors and management.…”

Are There Clinical or Pathological Parameters of Maxillary Oral Squamous Cell Carcinoma With an Influence on the Occurrence of Neck Node Metastasis? An Appraisal of 92 Patients

“…Ó 2015 American Association of Oral and Maxillofacial Surgeons J Oral Maxillofac Surg -: [1][2][3][4][5][6][7][8]2015 Oral squamous cell carcinoma (OSCC) arising from maxillary sites constitutes approximately only 3% of all intraoral SCCs. 1 Although research investigating the pathogenesis, clinical and pathologic behavior, recurrence rates, and risk of lymphogenic dissemination of maxillary OSCC has increased recently, [2][3][4][5][6][7][8][9][10][11][12] the studies differ in sample size, disease and site definition, and methodology. Anatomic knowledge about the lymphatic drainage of the maxillary tissues is ambiguous because it involves the submandibular and jugulodigastric lymph nodes and retropharyngeal nodes, which have limited accessibility for surgery.…”