Is Mycosis Fungoides a Reticuloendothelial Neoplastic Entity?

Cawley, Edward P.

doi:10.1001/archderm.1951.01570090002001

Cited by 72 publications

(4 citation statements)

References 21 publications

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“…Less classic extracutaneous involvement may be more difficult to differentiate from other malig nant lymphomas with cellular patterns resembling Hodgkin's disease or histiocytic or lymphocytic lymphoma. Although many authors believe that these patterns represent transition of MF into other malignant lymphomas (51,52), others regard them as variants of MF itself.and deny that such transition takes place (16,17).…”

Section: Histopathology Of Extracutaneous Involvementmentioning

confidence: 99%

Current Problems in Mycosis Fungoides and Sezary Syndrome

Winkelmann¹,

A.²

1977

Annu. Rev. Med.

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Section: Histopathology Of Extracutaneous Involvementmentioning

confidence: 99%

Current Problems in Mycosis Fungoides and Sezary Syndrome

Winkelmann¹,

A.²

1977

Annu. Rev. Med.

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“…As recent work has continued to clarify the nature of this malignant process, it has become increasingly evident that the Sezary syndrome represents a part of the larger spectrum of MF.9,1"313, 36,37 Although there is now considerable information with survival. 19,25,28,31,60,61 0008-543X/80/121.5/2654 $1.15 0 American Cancer Society No. 12 respect to the histogenesis of MF, causal factors remain obscure.…”

mentioning

confidence: 99%

Mycosis fungoides: Clinicopathologic relationships, survival, and therapy in 59 patients with observations on occupation as a new prognostic factor

Cohen

Stenn

Braverman

et al. 1980

Cancer

105

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Clinicopathologic relationships, survival and therapy were reviewed in 59 patients with mycosis fungoides (MF). An analysis of patient survival disclosed that stage of disease was a significant prognostic variable only if both cutaneous and visceral manifestations were considered in the staging design. The classical three-stage format, based solely on findings of eczema (I), plaques (II), or skin tumors (III), was not a significant factor in predicting survival. However, the inclusion of lymphadenopathy (IV) and organomegaly (V) or circulation Sézary cells (VI) in an expanded model revealed a significant decline in the probability of survival with increasing stage of disease. Regarding cases where the original histopathologic material was available for review, there was no association between the histologic stage of the specimen and the morphology of skin lesions. These data militate against the use of a staging scheme based on histologic criteria. Among 30 different types of treatment employed during the course of this study, highdose electron beam was superior to all other physical and chemotherapeutic modalities. In a case-control study considering occupational factors, patients with MF who were employed in manufacturing or construction industries were at significantly increased risk (relative risk = 4.3). Patient survival was reduced considerably for those with industrial backgrounds, suggesting that this subgroup was inclined to have severe disease. The concept that occupational factors may be implicated in the etiology of mycosis fungoides provides a new dimension to previous pathogenic hypotheses that needs further evaluation.

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“…Upon review of the literature, oral CTCL was more common in men with a 1.6 male:female ratio (shown in Table 1). Race was only reported in 20 cases with more case reports in Caucasians (17) than in African Americans (2) or those of other races (1). The mean age at diagnosis of CTCL was 58 years old (range 12-85 years old).…”

Section: Discussion/conclusionmentioning

confidence: 99%

Oral Mycosis Fungoides: Report of 2 Cases and Review of the Literature

Alexander-Savino¹,

Boye-Doe²,

Bowers³

et al. 2023

Case Rep Dermatol

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Oral and laryngeal cutaneous T-cell lymphoma (CTCL) is rare and usually associated with poor prognosis. Here, we discuss 2 cases of oral CTCL that developed in heavily pretreated patients and provide a review of the literature. The first case is of a 46-year-old African American male with rapidly progressive disease, presenting with a lesion on his hard palate 6 months after being diagnosed with a CD4+CD8+ CTCL. His cutaneous disease was widespread with tumors on >80% of his body surface area. Unfortunately, the patient died 2 ½ years after his CTCL diagnosis and 7 months after developing the oral CTCL lesion. The second case is of a 38-year-old African American male with stage IIb CD3+CD4+CD30+ mycosis fungoides (MF), who developed a tumor on the hard palate 6 months after diagnosis. He received palliative radiation to the oral lesion and multiple lines of systemic therapy for pulmonary, laryngeal, esophageal, and gastric involvement. Biopsy of the gastric lesions showed a CD30+ T-cell lymphoma with the same clonal peak as in his skin but with large cell transformation. Brentuximab vendoin was started, and the patient is now in complete remission, 30 months later. From the 76 cases of oral CTCL that have been reported in the English language, six were of transformed MF. The most common sites affected were the tongue and palate, and the most common presentation were erythematous or ulcerated tumors, plaques, or nodules associated with dysphagia and pain. Oral CTCL typically occurs years after the initial diagnosis of CTCL and portend a poor prognosis with an average survival of just over 1 year after development of oral lesions.

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Is Mycosis Fungoides a Reticuloendothelial Neoplastic Entity?

Cited by 72 publications

References 21 publications

Current Problems in Mycosis Fungoides and Sezary Syndrome

Current Problems in Mycosis Fungoides and Sezary Syndrome

Mycosis fungoides: Clinicopathologic relationships, survival, and therapy in 59 patients with observations on occupation as a new prognostic factor

Oral Mycosis Fungoides: Report of 2 Cases and Review of the Literature

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