Is Mycophenolic Acid Effective for the Treatment of Pemphigus?

An evaluation of the usefulness of mycophenolate mofetil in pemphigus

“…They report a similar incidence of lymphopenia but a higher incidence of gastrointestinal side‐effects experienced by five of 11 patients, that may be related to either MMF or corticosteroid therapy. It has been argued that the use of high‐dose corticosteroids in this study may make the interpretation of the usefulness of MMF difficult 22 …”

Evaluation of mycophenolate mofetil as a steroid‐sparing agent in pemphigus: a randomized, prospective study

“…There is a wide variation in the treatment of pemphigus, even among the world’s experts, which lies on the lack of large‐scale controlled studies and consensus standards concerning patient stratification and therapeutic strategies 4,5 …”

“…There is a wide variation in the treatment of pemphigus, even among the world's experts, which lies on the lack of large-scale controlled studies and consensus standards concerning patient stratification and therapeutic strategies. 4,5 The aim of this study was to assess the effectiveness of MMF as a steroid-sparing agent in patients suffering from pemphigus. Study design and protocol was based on previous studies, evaluating other steroid-sparing agents in pemphigus.…”

Mycophenolate mofetil

“…11 of 12 patients with PV who had failed azathioprine adjuvant therapy were clinically and immunologically free of disease after 2 months of a combined regimen of prednisone at 2 mg/kg/day and MMF at 2 g/day (46). Some have questioned the role of MMF in this study in light of the relatively high dose of prednisone used (47).…”