Is Mycobacterium avium subsp. paratuberculosis, the cause of Johne’s disease in animals, a good candidate for Crohn’s disease in man?

Singh, A. V.; Singh, Shoor Vir; Singh, Pravin Kumar; Sohal, J.S.

doi:10.1007/s12664-010-0019-y

Cited by 17 publications

(15 citation statements)

References 38 publications

(28 reference statements)

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“…MAP causes significant loss to the dairy industry in terms of decreased milk production and premature culling, increased mortality and decreased reproductive efficiency (Tiwari et al, 2005;. It is an acid-fast bacillus 0.5-1.5 µm in size and an intracellular fastidious pathogen which takes 12-16 weeks to grow (Singh et al, 2010;. Animals are infected with MAP early in life by ingestion of bacterium from infected milk or colostrum, or via farm environment, but clinical symptoms appear after 2-5 years (Eltholth et al, 2009;Anzabi & Hanifian, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…MAP is chiefly characterised by chronic inflammation of the intestine (Wuhib et al, 2005). It causes Crohn's disease in humans (Singh et al, 2010). Although the clear association is still not proven, it has been suggested that milk and dairy products could be possible vehicles of transmission of MAP from cattle to humans (Naser et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Isolation and molecular confirmation of Mycobacterium avium subspecies paratuberculosis in cattle and buffaloes from three states of India

Ramalakshmi¹,

Mukherjee²,

Prasad³

et al. 2016

BJVM

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, 2016. Isolation and molecular confirmation of Mycobacterium avium subspecies paratuberculosis in cattle and buffaloes from three states of India. Bulg. J. Vet. Med., 19, No 3,[189][190][191][192][193][194][195][196][197][198][199] In a random survey for identification of Mycobacterium avium subsp paratuberculosis (MAP) in cattle and buffaloes from states of Telangana, Maharashtra and Gujarat in India, a single time point sampling of 1,008 animals was undertaken. The samples: milk (n=605), faeces (n=381) and necropsy/post-mortem tissues (n=22) were initially processed for isolation of MAP in the MGIT BACTEC 960 system, which detected 22 out of 1,008 as MAP. All 22 samples were sub-cultured in Middlebrook 7H10 agar, Herrold's Egg Yolk medium (HYEM) and 7H9 broth supplemented with Mycobactin J. The three media showed different sensitivities in supporting the growth of field MAP strains. Only 9 out of 22 BACTEC 960 positive cultures grew on Middlebrook 7H10 agar, and 7H9 broth supplemented with Mycobactin J, while 8 out of 22 cultures grew on HYEM. Seven out of 9 positive cultures originated from milk samples from cattle, while the remaining 2 positive cultures were from necropsy and post-mortem tissues of cattle and buffalo respectively. MAP could not be isolated from faecal samples. All cultures grown on 7H10 agar, HYEM, 7H9 broth supplemented with Mycobactin J revealed acid fast bacilli on staining. In a recently developed in-house Real Time PCR targeting the MAP-specific insertion element ISMav2, only 8 out of the 9 field isolates were identified as MAP.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Isolation and molecular confirmation of Mycobacterium avium subspecies paratuberculosis in cattle and buffaloes from three states of India

Ramalakshmi¹,

Mukherjee²,

Prasad³

et al. 2016

BJVM

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“…The shedding of MAP organism through faeces and milk contaminates the environment animals live in. Presence of MAP in milk and its ability to survive pasteurization raises alarm bells as new research findings its zoonotic potential in Crohn's Disease (CD) (Singh et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Nanotechnology Based Therapeutics, Drug Delivery Mechanisms and Vaccination approaches for Countering Mycobacterium avium subspecies paratuberculosis (MAP) Associated Diseases

Stephen¹,

Jain²,

Dhama³

et al. 2015

Asian J. of Animal and Veterinary Advances

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Johne's Disease (JD) is a contagious fatal granulomatous enteritis, known to affect ruminants and is caused by the acid-fast Mycobacterium avium subspecies paratuberculosis (MAP). The bacterium has also been linked to Crohn's Disease (CD) in humans. Treatment options are scarce with culling practiced in the case of Johne's Disease (JD) and administration of anti-inflammatory drugs for pain and inflammation in case of CD. In both cases antimicrobial therapy against MAP does not have the ultimate potential. The very promising, yet untapped potential of nanotechnology offers a suitable platform for developing new therapeutic strategies for diseases caused by the bacteria. Uniformity, specificity and reproducibility are some of the characteristics of nanotechnology that can be exploited for the treatment of infectious diseases. Factors like cost, efficacy, safety and bioavailability of drugs can be greatly improved when the drugs are delivered with precision and at a controlled delivery rate to the target location. Nanotechnology can help in achieving these targets. This review discusses the current scenario of available therapeutic approaches and proposes drugs targeting strategies and vaccine development methods for the treatment and prevention of MAP related diseases.

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“…paratuberculosis (MAP) is a cause of a granulomatous bowel disease in cattle. It has been isolated from CD tissues and therefore it has been suggested that it may be a cause of CD in man [136][137][138]. A multicenter study in Australia randomized 213 CD patients to treatment aimed at MAP using clarithromycin 750 mg/day, rifabutin 450 mg/day, and clofazimine 50 mg/day or to placebo [139].…”

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confidence: 99%

Indian Society of Gastroenterology consensus statements on Crohn’s disease in India

Ramakrishna

Makharia

Ahuja

et al. 2015

Indian J Gastroenterol

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In 2012, the Indian Society of Gastroenterology's Task Force on Inflammatory Bowel Diseases undertook an exercise to produce consensus statements on Crohn's disease (CD). This consensus, produced through a modified Delphi process, reflects our current recommendations for the diagnosis and management of CD in India. The consensus statements are intended to serve as a reference point for teaching, clinical practice, and research in India.

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Is Mycobacterium avium subsp. paratuberculosis, the cause of Johne’s disease in animals, a good candidate for Crohn’s disease in man?

Cited by 17 publications

References 38 publications

Isolation and molecular confirmation of Mycobacterium avium subspecies paratuberculosis in cattle and buffaloes from three states of India

Isolation and molecular confirmation of Mycobacterium avium subspecies paratuberculosis in cattle and buffaloes from three states of India

Nanotechnology Based Therapeutics, Drug Delivery Mechanisms and Vaccination approaches for Countering Mycobacterium avium subspecies paratuberculosis (MAP) Associated Diseases

Indian Society of Gastroenterology consensus statements on Crohn’s disease in India

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