Is Mean Platelet Volume Increased in Behcet's Disease with Thrombosis?

Lee, Woong Soo; Kim, Think‐You

doi:10.1620/tjem.222.225

Cited by 14 publications

(25 citation statements)

References 5 publications

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“…Similar to our results Lee and Kim reported lower MPV values in their BD patients when compared with their control group [23]. Distinctly their study population also includes BD patients with thrombosis and they did not find any significant difference between the subgroups in MPV levels.…”

Section: Discussionsupporting

confidence: 88%

Mean Platelet Volume in Ocular Behçet’s Disease

Türkçü

Cingü

Yüksel

et al. 2013

The Scientific World Journal

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Objective. To determine whether mean platelet volume (MPV) is an indicator of disease severity in ocular Behçet's Disease (BD). Materials and Methods. The study population was 30 newly diagnosed ocular BD patients who presented with active uveitis. These patients had no past history of smoking, drug use, or systemic diseases including diabetes mellitus, hypertension, cardiovascular disease, and renal disease. A control group consisting of 34 healthy individuals was included for comparison. MPV measurements were performed serially upon presentation with active uveitis and at one and three month thereafter in BD group whereas only at presentation in the controls. Results. Upon presentation with active uveitis, the mean MPV levels were 7.88 ± 1.14 femtoliters (fL) for BD group. During the posttreatment follow-up period at first and third months, BD patients demonstrated a mean MPV level of 7.71 ± 1.12 fL and 7.65 ± 1.04 fL, respectively. The mean MPV value of control group, was 8.39 ± 0.66 fL at presentation. Fluctuations in MPV values were not significant in the BD group, while there was a significant difference between the initial measurements of the BD and control groups. Conclusion. MPV measurement in ocular BD is not a predictive laboratory test to determine the clinical improvement in early stages following classical immunosuppressive treatment.

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Section: Discussionsupporting

confidence: 88%

Mean Platelet Volume in Ocular Behçet’s Disease

Türkçü

Cingü

Yüksel

et al. 2013

The Scientific World Journal

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“…We recently reported that mean platelet volume (MPV) was higher in patients with BD than control and we concluded that increase in MPV was independent from the disease activity and thrombosis was associated with the higher MPV values (Acikgoz et al 2010). In contrast to our results, Lee and Kim (2010) found that MPV was lower in patients with BD than control groups. In addition, there was no difference in white blood cell (WBC) and MPV in BD patients with or without clinical manifestations such as thrombosis, genital ulcers and uveitis.…”

Section: Response: Is Mean Platelet Volume Increased In Behcet's Disecontrasting

confidence: 99%

Response: Is Mean Platelet Volume Increased in Behcet's Disease with Thrombosis?

Açıkgöz

Karincaoglu

Ermiş

et al. 2010

Tohoku J. Exp. Med.

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“…Lee et al [23] also found no differences in MPV in relation to thrombotic events. However, these authors did not indicate the criteria used for classifying patients as suffering BD.…”

Section: Discussionmentioning

confidence: 92%

“…The role played by MPV in the pathogenesis of thrombotic events in BD patients remains a question of debate. In a Turkish study [1], BD patients with thrombosis showed a higher MPV than those without thrombosis, whereas a Korean study [23] found no differences in MPV in relation to thrombotic events. Moreover, no studies have been performed on a possible association between MPV and posterior uveitis, one of the main causes of loss of vision in BD patients.…”

Section: Introductionmentioning

confidence: 88%

“…Endothelial dysfunction resulting from vascular inflammation is an important factor of thrombosis [6]. However, injury of the vascular endothelium itself cannot completely explain the hypercoagulable state of the disease because other vasculitis syndromes do not enhance the risk of thrombosis [23]. In fact, hypercoagulability and hypofibrinolysis also seem to be important factors in thrombosis development [11,13,29,32,33].…”

Section: Introductionmentioning

confidence: 99%

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Mean platelet volume does not seem to relate to thrombosis or posterior uveitis in Behçet's disease

Ricart

España

Navarro

et al. 2013

Clinical Hemorheology and Microcirculation

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Behçet's disease (BD) is a chronic inflammatory disorder in which thrombosis and posterior ocular involvement occur in about 30% of patients, whose ethiology is unknown. It has not been established whether mean platelet volume (MPV), a marker of platelet activation, is involved in the pathogenesis of thrombotic events and posterior uveitis in these patients. We aimed to analyze whether there are differences in MPV in BD patients when compared with controls and its relation with the presence of thrombosis and posterior uveitis. We determined MPV and platelet count, along with Creactive protein (CRP) and cardiovascular risk factors (because of their influence on MPV) in 89 BD patients (of which 24 had thrombosis and 23 had posterior uveitis) and 89 sex-and age-matched healthy controls. BD patients showed statistically higher MPV than controls: 10.98 ± 1.19 fL vs. 10.60 ± 1.21 fL (P = 0.044) and higher CRP: 5.9 ± 8.9 mg/L vs. 1.4 ± 1.7 mg/L (P = 0.001). The percentage of hyperlipemia and diabetes was higher in cases than in controls (P = 0.032, P = 0.013, respectively). No differences in MPV were observed when comparing: patients with and without thrombosis: 11.8 ± 1.27 fL vs. 10.94 ± 1.28 fL (P = 0.654); with and without posterior uveitis: 10.76 ± 1.18 fL vs. 11.03 ± 1.30 fL P = 0.398; with CRP and cardiovascular risk factors (P > 0.05). MPV correlated negatively with platelet count (r = -308, P < 0.01), but not with CRP (r = -0.22, P = 0.772). MPV seems to relate to neither thrombosis nor posterior uveitis in BD patients.

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Is Mean Platelet Volume Increased in Behcet's Disease with Thrombosis?

Cited by 14 publications

References 5 publications

Mean Platelet Volume in Ocular Behçet’s Disease

Mean Platelet Volume in Ocular Behçet’s Disease

Response: Is Mean Platelet Volume Increased in Behcet's Disease with Thrombosis?

Mean platelet volume does not seem to relate to thrombosis or posterior uveitis in Behçet's disease

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