Is it possible to actively and purposely make use of plasticity and adaptability in the neurorehabilitation treatment of multiple sclerosis patients? A pilot project

Řasová, Kamila; Krásenský, Jan; Havrdová, Eva; Obenberger, J; Seidel, Z; Doležal, Ondřej; Rexova, P; Zálišová, M

doi:10.1191/0269215505cr831oa

Cited by 33 publications

(28 citation statements)

References 22 publications

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“…While no studies to our knowledge have examined changes in brain activation in cognition following cognitive rehabilitation in MS, studies have examined changes post-intervention in the motor domain in MS [15,16]. In controls, Poldrack et al [17] showed that practiced mirror reading resulted in decreased activation in occipital, inferior temporal, and superior parietal cortices and increased activation in occipito-parietal and lateral temporal regions on fMRI.…”

Section: Functional Neuroimaging In Msmentioning

confidence: 97%

Increased cerebral activation after behavioral treatment for memory deficits in MS

et al. 2012

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Deficits in new learning and memory are common in persons with multiple sclerosis (MS), though few studies have examined the efficacy of memory retraining in MS. Previous research from our laboratory has demonstrated that the modified Story Memory Technique (mSMT) significantly improves new learning and memory in MS. The present double-blind, placebo-controlled, randomized clinical trial was designed to examine changes in cerebral activation following mSMT treatment. Sixteen individuals with clinically definite MS were randomly assigned to treatment (n = 8) or placebo-control (n = 8) groups, matched for age, education, and disease characteristics. Baseline and follow-up fMRI was collected during performance of learning and memory tasks. No baseline activation differences on fMRI were seen between groups. After treatment, greater activation was evident in the treatment group during performance of a memory task within a widespread cortical network involving frontal, parietal, precuneus, and parahippocampal regions. All participants in the treatment group showed increased activation in frontal and temporal regions in particular. In contrast, the control group showed no significant changes in cerebral activation at follow-up. A significant association was found between increased activation in the right middle frontal gyrus and improved memory performance post-treatment. The increased activation seen likely reflects increased use of strategies taught during treatment when learning new information. This study is the first to demonstrate a significant change in cerebral activation resulting from a behavioral memory intervention in an MS sample. Behavioral interventions can show significant changes in the brain, validating clinical utility.

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Section: Functional Neuroimaging In Msmentioning

confidence: 97%

Increased cerebral activation after behavioral treatment for memory deficits in MS

et al. 2012

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“…Some studies suggest that some cortical reorganization in patients with MS may occur, but it is unclear whether this plays a role in MS rehabilitation (Rasova et al 2005). The main effect is likely to be a consequence of improved compensation, adaptation and reconditioning (Rocca et al 2002).…”

Section: Future Of Robotics Technology In the Rehabilitation Of Ms Sumentioning

confidence: 98%

A Haptic Robot Reveals the Adaptation Capability of Individuals with Multiple Sclerosis

Casadio

Sanguineti²,

Solaro³

et al. 2007

The International Journal of Robotics Research

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A prerequisite for rehabilitation is that patients preserve their ability to adapt to novel dynamic environments, an ability that has been associated with the cerebellar system. In this study, we use a robot manipulandum to assess the ability of multiple sclerosis (MS) subjects in the early phase of the disease to adapt to a speed-dependent force field. Their performance is compared with an equal number of age-matched controls. We found that MS subjects display subtle incoordination problems but do not significantly differ from controls in their ability to adapt to the force field. These findings are discussed in terms of the possible benefits that MS subjects might receive from robot-assisted therapy that is specifically aimed at impaired visuomotor coordination.

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“…Six studies investigated whether motor rehabilitation strategies enhance brain plasticity, as evaluated by either task-related fMRI ( n = 2) [ 26 , 27 ], DTI ( n = 3) [ 28 – 30 ], or both techniques ( n = 1) [ 31 ] (see Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

Functional and Structural Brain Plasticity Enhanced by Motor and Cognitive Rehabilitation in Multiple Sclerosis

et al. 2015

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Rehabilitation is recognized to be important in ameliorating motor and cognitive functions, reducing disease burden, and improving quality of life in patients with multiple sclerosis (MS). In this systematic review, we summarize the existing evidences that motor and cognitive rehabilitation may enhance functional and structural brain plasticity in patients with MS, as assessed by means of the most advanced neuroimaging techniques, including diffusion tensor imaging and task-related and resting-state functional magnetic resonance imaging (MRI). In most cases, the rehabilitation program was based on computer-assisted/video game exercises performed in either an outpatient or home setting. Despite their heterogeneity, all the included studies describe changes in white matter microarchitecture, in task-related activation, and/or in functional connectivity following both task-oriented and selective training. When explored, relevant correlation between improved function and MRI-detected brain changes was often found, supporting the hypothesis that training-induced brain plasticity is specifically linked to the trained domain. Small sample sizes, lack of randomization and/or an active control group, as well as missed relationship between MRI-detected changes and clinical performance, are the major drawbacks of the selected studies. Knowledge gaps in this field of research are also discussed to provide a framework for future investigations.

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Is it possible to actively and purposely make use of plasticity and adaptability in the neurorehabilitation treatment of multiple sclerosis patients? A pilot project

Abstract: Clinical changes seen with neurorehabilitation were not associated with any detectable changes in fMRI observations.

Cited by 33 publications

References 22 publications

Increased cerebral activation after behavioral treatment for memory deficits in MS

Increased cerebral activation after behavioral treatment for memory deficits in MS

A Haptic Robot Reveals the Adaptation Capability of Individuals with Multiple Sclerosis

Functional and Structural Brain Plasticity Enhanced by Motor and Cognitive Rehabilitation in Multiple Sclerosis

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