Is injectable collagen truly safe?

Abstract

Most patients have no response to injectable collagen or silicone, but some cases may have positive or ‘undersea’(= clinically negative but immunologically positive) response to collagen. From the results of the Macrophage migration inhibition test, the relative immunogenicity was augmented most when we used implants with the following combination. The firstimmunization was collagen and the second one was collagen with silicone.The augmented antigenicity might be enough to cause an allergic reaction to the patients who had no response to each implant alone. The purpose of this article is to warn of the potential hazard of injection.

Adaptive amino acid composition in collagens of parasitic nematodes

“…Animal-derived collagen is widely used as a biomaterial for tissue engineering in human patients, but the potential for immunogenicity remains a concern (Takayama et al, 1992;Lynn et al, 2004;Parenteau-Bareil et al, 2010). The possibility that natural selection has yielded unusually poorly antigenic collagens in parasitic nematodes may provide insights in guiding the engineering of a new generation of poorly antigenic collagens for medical applications.…”

Injection Laryngoplasty Materials

“…Deri içine yapılan 0,1 ml enjeksiyondan sonra 2-6 hafta gözlem amacı ile beklenir [30]. Deri testi negatif olsa dahi aşırı duyarlılık reaksiyonları geliştiğine dair bildiriler de söz konusudur [31,32]. 27G iğne ile enjekte edilebilir ve ses kıvrımın-da kalma süresi 4-6 haftadır [7].…”

Uso da gordura e fáscia muscular autólogas no tratamento da insuficiência glótica

“…Even if no reaction that could seriously impair patients has ever been documented, the use of a bovine protein deep in the lamina propria did not make us feel safe. Previously performed intradermal tests could not guarantee clinical safety 6 . Human collagen has been recently proposed.…”