Male circumcision (MC) is common in many countries. Despite clear health benefits, ethical arguments have been invoked opposing MC, especially when performed neonatally (NMC). NMC is when most MCs are performed in developed countries. Here we provide the first PRISMA-compliant systematic review of the disparate evidence of ethical and legal arguments concerning NMC and MC of older boys. Searches were performed of PubMed, Embase and Scopus for publications relevant to ethical and legal aspects of MC in developed Anglophone and European countries. This led to retrieval of 48 articles meeting the inclusion criteria. A further 18 articles and 16 Internet publications were identified from searches of bibliographies of articles retrieved. Two more were supplied by a legal academic colleague. In total 84 publications were reviewed. The literature revealed arguments by some that parent-approved MC of a nonconsenting child is unethical. But parental consent also applies to vaccination and all other medical therapies in children. Strong data support a conclusion that: (1) NMC is low risk, (2) NMC provides immediate and lifetime medical and health benefits, and (3) NMC has no adverse effect on sexual function and pleasure. The United Nations Convention on the Rights of the Child articulates the right to health and focuses on the best interests of the child as its guiding principle. Discouraging or denying MC to neonates is arguably unethical, given the overwhelming health benefits. Legal scholars regard case-law as supporting the legality of NMC. Ethical and legal arguments support the rights of males of all ages to lifetime protection against infection and diseases caused by lack of MC. Arguments opposing NMC generally involve distortion of the medical evidence, poorly designed studies and opinions. Opposition to NMC goes against the principles of evidence-based medicine used in reviews conducted to develop pediatric policies in support of optimum public health, sexual health, mental health, and human rights.