Is Hepatitis E a Vaccine Preventable Diseases?

Mardani, Masoud

doi:10.5812/archcid.10(2)2015.28726

Cited by 1 publication

(1 citation statement)

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“…Like HAV, HEV is usually an acute self-limiting disease and with no progression to a chronic disease state. Since, there is no a suitable cell culture system for efficient HEV replication and susceptible small laboratory animal, Construction a live/attenuated vaccines is not possible [15]. The purpose of this study was to evaluate the seroprevalence characteristics of HAV and HEV and their co-infection among Iranian soldiers to determine whether vaccination should be administered routinely in Iranian army draftees.…”

Section: Introductionmentioning

confidence: 99%

First report of simultaneous assessment of hepatitis A virus and hepatitis E virus seroprevalence among soldiers in Iran

Ghorban

Dadmanesh

Mohammadnezhad

et al. 2022

jcbior

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Hepatitis E virus (HEV) and Hepatitis A virus (HAV) have been considered as common causes of viral hepatitis to military service members since their discovery. Although Iran has been recognized as an endemic country for HAV and HEV there is no study about HAV and HEV simultaneous prevalence among Iranian soldiers. The purpose of this study was to assess anti-HAV and anti-HEV antibodies in Iranian soldiers concurrently. In this cross-sectional study, a total of 400 serum samples were collected by simple random sampling for detection of anti-HAV and anti-HEV IgG by commercial HEV enzymelinked immunosorbent assay (ELISA) kit. Out of 400 individuals, all participants were male with ages ranging from 18 to 26 years. Totally, 12% and 0.5% of the tested specimens were positive for anti-HAV and anti-HEV respectively. There were no significant differences between the subjects grouped according to age groups. Our finding presented a dramatic decrease in seropositivity against HAV. Therefore, vaccination for HAV should be reevaluated for military services in Iran.

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Section: Introductionmentioning

confidence: 99%